Recombinant Mouse P2Y purinoceptor 1 (P2ry1), partial

1. upregulation of P2Y1 in cutaneous nociceptors during early life peripheral inflammation can regulate the sensitization of myelinated nociceptors to both mechanical and heat stimuli possibly through modulation of transient receptor potential vanilloid type 1 expression PMID: 28845731
2. This study demonstrated that The inhibitory input to mouse cerebellar Purkinje cells is reciprocally modulated by Bergmann glial P2Y1 and AMPA receptor signaling. PMID: 27144942
3. LPS-induced inflammation levels were comparable in the P2Y1-null and wild-type mice. Specifically, splenomegaly, counts of circulating platelets and white blood cells (lymphocytes and neutrophils), and assessments of lung injury (tissue architecture and cell infiltration) were similar in the P2Y1-null and wild-type mice. I conclude that lung injury during LPS-induced inflammation in mice is independent of P2Y1 signaling. PMID: 27815804
4. In P2Y12(-/-) mice, the growth of syngeneic ovarian cancer tumors was reduced by >85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1(-/-) and WT mice. PMID: 28679740
5. Mesenteric endothelial cells are primed by schistosomiasis to a pro-inflammatory phenotype characterized by an increased expression of NTPDases 2 and 3, favoring ADP accumulation and mononuclear cell adhesion, possibly contributing to mesenteric inflammation and schistosomiasis morbidity via P2Y1 receptor signaling. PMID: 26924460
6. the amounts of AChE activity, AChE catalytic subunit, structure subunit PRiMA and the amount of acetylcholine, in the brain were not, significantly, altered, suggesting the role of P2Y1R in neuron could have different function as that in muscle. PMID: 27378627
7. In P2Y1R (-/-) mice, the expression of P2Y2 receptor in muscle was reduced by over 50 %, as compared to P2Y1R (+/+) mice. P2Y1 receptor regulated the neuromuscular junction gene expression. PMID: 26036470
8. Our current results suggest that P2Y1 modulates heat responsiveness and chemosensation in muscle afferents to play a key role in the development of pain-related behaviors during ischemia. PMID: 26740646
9. Antibody EL2Ab binds to and exhibits P2Y1R-dependent function-blocking activity in the context of platelets. PMID: 25593131
10. P2Y1 couples to and activates TRPV4. PKC inhibitors prevented P2Y1 receptor activation of TRPV4. PMID: 26475857
11. The results of this study indicated that activation of the P2Y1R stimulates fibre growth and thereby emphasises the general role of this particular receptor subtype during development and regeneration. PMID: 25683778
12. The analysis of single and double KO mice demonstrated that NTPDase2 and P2Y1 receptors are not required for murine eye formation PMID: 25504514
13. Data indicate that knock down of purinergic P2Y1 receptors inhibited directed migration in neurospheres. PMID: 25096637
14. In a mouse model of Alzheimer disease, astroglial network dysfunction is mediated by P2Y1 receptor signalling in reactive astrocytes. PMID: 25406732
15. P2Y1R-KO mice displayed reduced cell numbers in the ganglion cell and inner nuclear layers, ischemia induced apoptotic death of cells in all retinal layers. PMID: 25077539
16. This study shows that Up4A is a potent native agonist for P2Y1R and SK-channel activation in human and mouse colon. PMID: 25341729
17. RhoA signaling downstream of platelet P2Y, but not P2Y, represents a clear dichotomy in platelet activation during allergic inflammation versus hemostasis. PMID: 25445826
18. purines activate SK currents via mainly P2Y1 receptors in PDGFRalpha(+) cells PMID: 24396055
19. It involves in LPS-induced IL-6 production in Kupffer cells, leading to the liver inflammation. PMID: 24849676
20. P2Y(1)-purinoceptors are not involved in the OFF-pathway-specific signal transmission in cholinergic amacrine cells of the mouse retina. PMID: 23907621
21. The purinergic receptor P2Y1 mediates migration of neuroblasts within naturally occurring electric fields in the mouse brain. PMID: 23328740
22. Activation of P2Y1 receptors in the glomerulus can stimulate network activity in the olfactory bulb. PMID: 22187118
23. results demonstrate a crosstalk between two metabotropic and one ionotropic purinergic receptor that regulates cAMP levels through adenylate cyclase 5 and modulates axonal elongation triggered by neurotropic factors and the PI3K-Akt-GSK3 pathway PMID: 22250198
24. The results of this study suggested that 9acGD3 controls granule cell progenitor migration by influencing P2Y(1)R cellular distribution and function. PMID: 22894715
25. The current study demonstrates that P2Y1 deletion or antagonism significantly reduced venous thrombosis in mice, suggesting that P2Y1 receptors play a role in the pathogenesis of venous thrombosis PMID: 22588534
26. In P2Y(1)(-/-) mice, EFS responses were completely blocked by L-NNA. PMID: 22371472
27. Purinergic responses were abolished in P2ry1(-/-) mice. PMID: 22371476
28. Inflammation-induced enhanced expression of P2Y1 is required for normal heat sensitization of cutaneous nociceptor fibers. P2Y1 plays a role in the maintenance of phenotype in cutaneous afferent fibers. PMID: 22137295
29. Purinergic signaling promotes the proliferation of rapidly dividing cells and transit-amplifying cells in the subventricular zone niche through the P2Y1 receptor. PMID: 22764232
30. Activation of P2Y1 and P2Y2 receptors induces chloride secretion via calcium-activated chloride channels in kidney inner medullary collecting duct cells. PMID: 21653634
31. The endothelial P2Yreceptor plays a key role in acute vascular inflammation and leukocyte recruitment in apoliproptein E-deficient mice. PMID: 21576651
32. Purinergic receptor P2RY1 stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria PMID: 21203502
33. analysis of a novel Gi, P2Y-independent signaling pathway mediating Akt phosphorylation in response to thrombin receptors PMID: 20586915
34. results demonstrate a role for the P2Y1 receptor in both arterial and venous thrombosis; combination of P2Y1 deficiency with P2Y12 inhibition led to a significant additive effect in reducing thrombosis PMID: 12871312
35. In P2Y1-deficient mice, the ability of collagen to enhance the generation of thrombin was impaired PMID: 12969982
36. Reduced expression of P2Y1 receptors in neural progenitor cells lacking connexin43 affects calcium signaling and cell migration. PMID: 14673009
37. Inhibition of P2Y(1) alone prolonged the lag phase preceding aggregation in response to low or high concentrations of fibrillar collagen, without affecting the maximum amplitude of aggregation or secretion. PMID: 15140133
38. sequential expression of the P2X5, P2Y1, and P2X2 receptors during the process of muscle regeneration PMID: 15231720
39. the voltage dependence to Ca2+ release via Galphaq-coupled receptors is not due to control of G-proteins or down-stream signals but, rather, can be explained by a voltage sensitivity at the level of the P2Y1 receptor itself PMID: 15528188
40. In hippocampal slices, ATP activates P2Y1 receptors in the interneurons, which is linked to activation of unidentified excitatory conductance, through mechanisms distinct from those in the astrocytes. PMID: 15574734
41. ADP alone, used as a primary agonist, activated Rac and its effector PAK via its P2Y1 receptor, through a G(q)-dependent pathway and independently of P2Y12 PMID: 16194206
42. Induction of the osmolyte permeability in Plasmodium-infected erythrocytes involves autocrine purinoceptor signaling. PMID: 16267125
43. analysis of the coupling of purinergic P2Y1R to glutamate exocytosis and its peculiar TNFalpha- and PG-dependent control PMID: 16882655
44. examined calcium mobilization in platelets from mice that were either wild-type or homozygous null for PAR-4 or P2Y1 receptors, hypothesizing that the loss of PAR-4 or P2Y1 receptors would cause redistribution of its Galphaq proteins to other receptors PMID: 16973501
45. Loss of P2Y1 receptor function safeguards against capillary loss, fibrosis, and death by renal failure during experimental crescentic glomerulonephritis. PMID: 17215444
46. ATP released by nerve stimulation activates P2Y1 receptors, located prejunctionally, limiting its release by motoneurons PMID: 17997228
47. The P2Y(1) receptor contributes to atherosclerosis, primarily through its role in non-hematopoietic-derived cells. PMID: 18663083
48. Findings support a potential role for P2Y1Rs in regulation of vasopressin and oxytocin release in supraoptic nucleus neurons. PMID: 19515986

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KEGG: mmu:18441

STRING: 10090.ENSMUSP00000029331

UniGene: Mm.281452