Recombinant Mouse Peptidyl-prolyl cis-trans isomerase F, mitochondrial (Ppif)

1. Cyclophilin D is an important but non-obligatory regulator of mitoflash activity in cardiac muscle, whereas it is dispensable in the skeletal muscle, due in part to differential cyclophilin D expression. PMID: 26746144
2. Both male and female cypD heterozygous but not gene knockout mice exhibited increased lifespans compared to wild-type littermates, associated with alterations in the protein expression of some markers, albeit without exhibiting changes in behaviour. PMID: 28288917
3. Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart. PMID: 28230282
4. Binding of signal transducer and activator of transcription 3 (STAT3) to cyclophilin D (CypD) was important for reducing mitochondrial reactive oxygen species (ROS) production after oxidative stress. PMID: 28351946
5. these data demonstrate that mitochondria are impaired in aging bone and that CypD deletion protects against this impairment to prevent bone loss. This implicates CypD-regulated MPTP and mitochondrial dysfunction in the impairment of bone cells and in aging-related bone loss. PMID: 27183225
6. Ppif+/+ and Ppif-/- eosinophils exhibited no significant difference in apoptosis or secondary necrosis. PMID: 26893161
7. Ischemic postconditioning might prevent lethal reperfusion injury through an increased SIRT3 activity and subsequent attenuation of CyPD acetylation at reperfusion. PMID: 25871830
8. These findings reveal the role of HAX-1 in regulating cyclophilin-D levels via an Hsp90-dependent mechanism, resulting in protection against activation of mPTP and subsequent cell death responses PMID: 26553996
9. study identifies a novel signaling pathway composed of E2F1, miR-30b and CypD that regulates myocardial necrosis. PMID: 25301066
10. It is concluded that CypD sensitizes the brain mitochondria to PT, and its inhibition by CsA or CypD absence improves the complex I-related mitochondrial function and increases mitochondria stability against Ca(2+) stress. PMID: 26032335
11. Data indicate that Ppif protein cyclophilin D (CypD)-dependent protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signaling is responsible for amyloid beta (Abeta)-induced synaptic injury. PMID: 23507145
12. It regulates Parkinson's disease development. PMID: 24325796
13. Ablation of CypD leads to changes in the mitochondrial acetylome which may contribute to altered mitochondrial metabolism in CypD-deficient mice. PMID: 24062335
14. These results suggest a physiologic function for CypD and the mitochondrial permeability transition in the regulation of starvation-induced autophagy. PMID: 20364102
15. new insights into CypD-dependent mitochondrial mPTP and signaling on mitochondrial trafficking in axons and synaptic degeneration in an environment enriched for Abeta PMID: 23382999
16. Cys-203 residue of CypD is necessary for redox stress-induced activation of mPTP. PMID: 21930693
17. Data suggest that, in mitochondria exhibiting intact inner membranes, the absence of cyclophilin D or the inhibition of its binding to F(0)F(1)-ATP synthase by cyclosporin A will affect only matrix adenine nucleotides levels. PMID: 21281446
18. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. PMID: 21212461
19. C1qbp could directly bind to CypD. Therefore C1qbp appears to act as an endogenous inhibitor of the MPT pore, most likely through binding to CypD, and thus protects cells against oxidative stress. PMID: 20950273
20. The CYPD component of the mPTP is required by myocardial ischemic preconditioning (IPC) to generate mitochondrial ROS and phosphorylate Akt and Erk1/2, major steps in the IPC signalling pathway. PMID: 20400621
21. have shown that Ppif(-/-) mice exhibit substantially greater cardiac hypertrophy, fibrosis, and reduction in myocardial function in response to pressure overload stimulation than control mice PMID: 20890047
22. cyclophilin D and the mitochondrial permeability transition are critical regulators of beta-cell death caused by Pdx1 insufficiency PMID: 20479245
23. mice lacking Cyp D display cognitive dysfunction probably caused by the hypofunction of neurotransmission without developmental abnormalities PMID: 19437409
24. results indicate that the CypD-dependent mitochondrial permeability transition regulates some forms of necrotic death, but not apoptotic death PMID: 15800626
25. cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death PMID: 15800627
26. CypD plays an essential role in an cerebral ischemic injury model in which calcium overload and oxidative stress have been implicated. PMID: 16103352
27. CyPD-KO mice were (i) more anxious and less explorative in open field and elevated plus maze and (ii) performed better in learning and memory of avoidance tasks, such as active and passive avoidance PMID: 18621101
28. Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation PMID: 18684715
29. Cyclophilin D gene ablation protects mice from ischemic renal injury. PMID: 19553348

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KEGG: mmu:105675

STRING: 10090.ENSMUSP00000022419

UniGene: Mm.41656