Recombinant Mouse Peroxiredoxin-6 (Prdx6)

1. Data (including data from studies in transgenic rats and knockout mice) suggest that Nfe2l2 and Prdx6 are involved in biosynthesis of palmitic acid ester of 9-hydroxystearic acid in white adipose tissue (WAT); these proteins appear to be play roles in defense against oxidative stress in WAT. (Nfe2l2 = nuclear factor erythroid 2-like 2 nuclear factor; Prdx6 = peroxiredoxin-6) PMID: 29549163
2. Our data indicate that a lack of the antioxidant enzyme PRDX6 protects against the development of acute and chronic experimental colitis and is associated with increased expression and function of other antioxidant enzymes PMID: 28199527
3. The constitutive elevations of Prdx6 and NF-kappaB during Clonorchis sinensis infection may be associated with more severe persistent hepatobiliary abnormalities mediated by clonorchiasis. PMID: 27554973
4. Detailed analysis of the redox-active cysteine in one protein in the nerve of old mice that is key to redox signalling (Peroxiredoxin 6, Cys 47) showed a minor increase in reversible oxidation that would be compatible with a change in its redox signalling function PMID: 26876649
5. The results suggest that PRDX1 contributes to host defenses against M. tuberculosis PRDX1 positively regulates IL-12 production by inducing c-Rel and activating p38 MAPK, and it positively regulates NO production by suppressing Arg1 expression in macrophages infected with M. tuberculosis. PMID: 27605010
6. This study indicated that Prdx6 decreased LPS-induced Muc5ac increase and played important roles in mucin hypersecretion after LPS exposure. PMID: 27884794
7. PRDX6 inhibited the carcinogenesis of hepatocellular carcinoma, and the calcium-independent phospholipase A2 activity of PRDX6 promoted cancer cell death induced by TNF-alpha. PMID: 26293541
8. Studies in knockout and knock-in mice showed that the phospholipase A2 activity of peroxiredoxin 6 activates NOX2 in cultured pulmonary endothelial cells and alveolar macrophages, clarifying the metabolism of lysophosphatidyl chold to lysophosphatidic acid. PMID: 27178323
9. Prdx6 knockout males are more vulnerable to oxidative stress than WT males, resulting in impairment of sperm quality and ability to fertilize the oocyte, compatible with the subfertility phenotype observed in these knockout mice. PMID: 26792942
10. Thr can substitute for Ser for the enzymatic activities of Prdx6 but not for its targeting to LB. These results confirm an important role for LB Prdx6 in the degradation and remodeling of lung surfactant phosphatidylcholine. PMID: 26921317
11. AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo PMID: 26907692
12. Prdx6 plays a critical role in the repair of peroxidized phospholipids in cell membranes and the recovery of lung cells from peroxidative stress; the peroxidase and PLA(2) activity each contribute to the recovery process. PMID: 26117327
13. The ventral signal observed from E13.5 to E18.5 colocalized with motor neuron markers Isl1/2 and FoxP1 and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord. PMID: 25975898
14. PRDX6 has a role in controlling multiple sclerosis by suppressing inflammation and blood brain barrier disruption PMID: 26327204
15. PRDX6 has an important role in dopaminergic neurodegeneration of Parkinson's disease. PMID: 25193021
16. Our findings suggest that overexpression of peroxiredoxin 6 might promote development of rheumatoid arthritis through NF-kappaB and AP-1 activity via the JNK pathway. PMID: 26211509
17. AA (arachidonic acid) as a crucial effector of PRDX6-dependent proliferation and inducer of Src family kinase activation. PMID: 26285655
18. PRDX6 promotes lung tumor development via its mediated and CCL5-associated activation of the JAK2/STAT3 pathway. PMID: 25582888
19. Data show that adduction of peroxiredoxin-6 sensitizes male C57BL/6 mice to toxicity by acetaminophen. PMID: 24563856
20. we demonstrated that PRDX6 is a key mediator of overt hyperglycemia in type 2 diabetes glucose metabolism, opening new perspectives for targeted therapeutic strategies in diabetes care. PMID: 24947358
21. The overexpression of Prdx6 could accelerate the development of Alzheimer's disease through increased amyloidogenesis through independent PLA2 activation and Nrf2 transcription. PMID: 23771816
22. Suggest that retinoic acid-induced Prdx 6 expression may be associated with rapid recovery from temporary noise-induced hearing loss. PMID: 23792233
23. p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 activity, an interaction that could function to terminate the PLA2-mediated NOX2 activation signal. PMID: 23401562
24. Yiqi chutan recipe can inhibit the growth and metastasis of Lewis lung carcinoma and reduce expression of PRDX1 and PRDX6. PMID: 21434354
25. Deletion of peroxiredoxin 6 exaggerated LPS-induced acute lung injury with increased oxidative stress. PMID: 22177494
26. Expression of mutant Prdx6 with either peroxidase activity or PLA(2) activity alone each partially rescued the survival of Prdx6 null cells, while constructs with both active sites mutated failed to rescue. PMID: 22067043
27. PRDX6 exists as a heterogeneous mixture of molecules containing a multitude of post translational modifications. PMID: 22589192
28. Data show that S100a9, Mmp10 and Ang2 were among the most downregulated genes, whereas Per3, Tef and Prdx6 were significantly upregulated in the DMH + Calcium group. PMID: 21857934
29. Results showed that CC26 and the expressed in developing to adult chemosensory epithelia with differential timing and the pattern of expression is not identical in VNO and olfactory epithelia as well as the corresponding associated glands. PMID: 21721139
30. prostaglandin D2 and prostaglandin E2 up-regulate gene expression in macrophages PMID: 21651978
31. These findings demonstrate that impaired homeostasis and progression of pathogenesis in Prdx6-deficient lens epithelial cells or in aging cells should be blocked by a supply of Prdx6. PMID: 21677259
32. Immunohistochemical analysis revealed segment-specific alterations induced by the ischemic insult. Grx2, Prx3, and Prx6 were highly expressed in proximal tubule cells PMID: 21586322
33. Lipopolysaccharide and interferon-gamma induced gene expression of peroxiredoxin 6 was also regulated in an NO-independent manner by cyclooxygenases and prostaglandin E2 PMID: 20869433
34. agonist-induced MAPK activation leads to Prdx6 phosphorylation and translocation to the cell membrane, where its PLA(2) activity facilitates assembly of the NOX2 complex and activation of the oxidase. PMID: 21262967
35. knock-out mice are significantly more sensitive to oxidant stress PMID: 20627125
36. Prdx6 plays a critical role in preventing acute oxidative lung injury. PMID: 19099877
37. Findings suggest that Fkbp52 deficiency diminishes the threshold against OS by reducing PRDX6 levels. PMID: 20713718
38. Data demonstrate an important anti-apoptotic function for Prdx6 in cancerous liver cells, and suggest that its up-regulation may be a tumor-supportive adaptation in cancerous states. PMID: 20003713
39. Prdx6-deficient lens epithelial cells are more vulnerable to UV-triggered cell death and display abnormal protein profiles. PMID: 19889963
40. Prdx6-/- mice had significantly lower survival rates, more severe tissue damage, and higher protein oxidation levels PMID: 12732627
41. alternative Aop2 transcripts may play distinct roles in different oxidative stress responses, and possibly in atherosclerosis PMID: 12804011
42. Prdx6 overexpression in transgenic mice is not sufficient to protect mice from atherosclerosis PMID: 14572613
43. stathmin expression is disregulated, and Hsp25, Hsp27, and peroxiredoxin 6 are upregulated in a mouse model of familial amyotrophic lateral sclerosis PMID: 15509539
44. Prdx6 has a role in lung surfactant dipalmitoylphosphatidylcholine degradation and synthesis by the reacylation pathway PMID: 15772425
45. PRDX6 in regulating gene expression by controlling the ROS level to maintain cellular homeostasis PMID: 15818411
46. SP-A and Prdx6 directly interact, which provides a mechanism for regulation of the PLA(2) activity of Prdx6 by SP-A PMID: 16330552
47. Tg mice have increased defense against lung injury in hyperoxia, providing evidence that Prd x 6 functions as a lung antioxidant enzyme. PMID: 16399955
48. Prdx6 deficient mice have increased susceptibility to lung injury with paraquat administration. PMID: 16487056
49. Peroxiredoxin 6 protects keratinocytes from cell death induced by reactive oxygen species in vitro and in vivo, suggesting that activation of this enzyme could be a novel strategy for skin protection under stress conditions. PMID: 17003478
50. Data support multiple pathways of Prdx6 regulation and reveal important promoter regions that mediate its transcriptional regulation. PMID: 17382207

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KEGG: mmu:11758

STRING: 10090.ENSMUSP00000071636

UniGene: Mm.186185