Recombinant Mouse Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Pik3cg), partial

1. Deficient mice in the canonical PI3Kgamma signaling (Pik3cg-/-) are more susceptible to T. cruzi infection. The canonical PI3Kgamma signaling in myeloid cells restricts heart parasitism and avoids heart damage and death of mice. PMID: 29666415
2. the beneficial action of PI3Kgamma ablation in obesity-driven glucose intolerance is largely a result of its leptin-dependent effects on adiposity and, to a lesser extent, the promotion of adipose tissue neutrophil recruitment and M1 polarization of gene expression PMID: 28904022
3. As blockade of PI3Kgamma or integrin alpha4 prevents accumulation of myeloid-derived suppressor cells and reduces myeloid cell expression of immunosuppressive factors that stimulate tumor immune escape, these results highlight PI3Kgamma and integrin alpha4 as targets for the design of cancer therapeutics. PMID: 28963139
4. PI3K( PI3Kgamma(null) versus PI3Kgamma(WT) mice) inhibition slows tumor growth, enhances antitumor immunity, and heightens susceptibility to immune checkpoint inhibitors. We propose that combining PI3K inhibition with anti-PD1 may be a viable therapeutic approach for triple-negative breast cancer PMID: 28003307
5. PI3Kg ablation protects mice from obesity, inflammation, and insulin resistance caused by high-fat diet feeding. PMID: 28720716
6. The results showed that PI3K-gamma is likely a crucial element in sepsis-induced myocardial dysfunction (SIMD) by regulating the PI3K/Akt pathway, and become a new marker of myocardial injury. Inhibition of PI3K-gamma might be a potential therapeutic target in SIMD. PMID: 28458167
7. Phosphatidylinositol-3-kinases (PI3K) gamma and delta are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kgamma or PI3Kdelta deficiency prolongs graft survival, but selective inhibition of PI3Kgamma or PI3Kdelta reveals alternative transplant survival outcomes post CTLA4-Ig treatment. PMID: 29038423
8. PI3Kgamma kinase activity-independent control of cAMP phosphodiesterase as a crucial mediator of microglial cAMP regulation, MMP-9 expression, and phagocytic activity following focal brain ischemia/recirculation. PMID: 26452362
9. We report here that PI3Kgamma regulates macrophage transcriptional programming, leading to T-cell suppression, desmoplasia, and metastasis in pancreas adenocarcinoma. PMID: 27179037
10. a STOP mutation in the GM-CSFRalpha chain, leading to a complete and specific deficiency in GM-CSF signaling, is reported. PMID: 27468760
11. increased levels of eosinophils and IgE in p110gamma/delta-/- mice do not abolish the protective effect of p110gamma/delta-deficiency against OVAlbumin-induced allergic airway inflammation. PMID: 27442134
12. The Effector PI3Kgamma Is Required for Toll-like Receptors-induced Akt/mTOR Signaling and Regulation of Cytokine Responses. PMID: 28130450
13. macrophage PI 3-kinase gamma controls a critical switch between immune stimulation and suppression during inflammation and cancer; therapeutic targeting of intracellular signalling pathways that regulate the switch between macrophage polarization states can control immune suppression in cancer and other disorders PMID: 27642729
14. Accumulation of PtdIns(3,4,5)P3, but not PtdIns(3,4)P2,in neutrophils were dependent on PI3Kgamma activity. PMID: 26596865
15. identify PI3Kgamma as a novel key host protective factor in influenza virus infection and shed light on an unappreciated layer of complexity concerning the role of PI3K signaling in this context PMID: 27030971
16. Pik3cg(-/-) mice had persistent lung inflammation induced by sepsis and increased in vascular permeability. Restoration of p110gamma in pulmonary endothelial cellsrestored endothelial regeneration and normalized the defective vascular repair program. PMID: 26839042
17. Results found that the absence of PI3Kgamma significantly delayed mortality and reduced clinical signs and histopathological brain changes associated with Plasmodium berghei infection. PMID: 25775137
18. The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB signaling exerted by a kinase-independent PI3Kgamma-PDE4D interaction in the noradrenergic neurons of the locus coeruleus. PMID: 25882071
19. platelet PI3Kgamma contributes to platelet-mediated vascular inflammation and carotid intima-media thickening after flow severely reduced. Platelet PI3Kgamma may be a new target in the treatment of vascular diseases. PMID: 26053836
20. The Ras-PI3Kgamma-Akt-mTOR signaling axis acts downstream of FLT3L signaling and is required for development of lung CD103(+)and CD11b(+) dendritic cells. PI3Kgamma is an essential organ-specific regulator of lung dendritic cell development PMID: 26453378
21. The regulatory subunits of PI3Kgamma control distinct neutrophil responses. PMID: 25605974
22. p110[gamma] but not p110[delta]-specific inhibitor ameliorates renal ischemia-reperfusion injury by reducing necrosis and immune cell migration PMID: 26431158
23. The interaction between PI3Kgamma and CNGA1 does not appear to play a role in regulation of CNG channel activity, but PI3Kgamma uses CNGA1 as an anchoring module to achieve close proximity to its substrate to generate D3-phosphoinositides PMID: 25644171
24. puerarin prevents Abeta-induced microglial apoptosis via the activation of PI3K/Akt signaling pathway PMID: 25173404
25. Combined inhibition of PI3Kbeta and PI3Kgamma reduces fat mass by enhancing alpha-MSH-dependent sympathetic drive, thus perhaps a promising treatment for obesity. PMID: 25406378
26. The lack of PI3Kgamma revealed a deleterious effect in an animal model of convulsions induced by pilocarpine, suggesting that this enzyme may play a protective role in seizures PMID: 25749189
27. Kinase-independent control of cAMP phosphodiesterase activity by PI3Kgamma is a crucial mediator of microglial cell activation, MMP expression and subsequent BBB deterioration. PMID: 25033932
28. These results, together with the previous knockout study, suggest that a critical level of PI3Kgamma in the hippocampus is required for successful induction of long-term depression and normal learning. PMID: 25373491
29. phosphatidylinositol 3-kinase gamma has a role in insulin secretion induced by glucose-dependent insulinotropic polypeptide PMID: 25288806
30. The data indicate that PI3Kgamma has a critical role in cAMP-mediated inflammatory hypernociception and analgesic signalling via mu-opioid receptors and PI3K/Akt in neuronal cells. PMID: 24654606
31. PI3Kgamma-deficient mice and mice expressing catalytically inactive PI3Kgamma (PI3Kgamma KD) showed reduced arterial occlusion and accumulation of monocytes and T cells around sites of vascular lesion. PMID: 25073791
32. PI3Kgamma kinase activity is required for optimal T-cell activation and differentiation, as well as for mounting an efficient T cell-mediated immune response. PMID: 24030559
33. PKCbeta-mediated p110gamma phosphorylation disconnects PI3Kgamma from its canonical inputs from trimeric G proteins. PMID: 23824069
34. IgE-mediated mast cell accumulation was strictly PI3Kgamma dependent in IGE challenged skin. PI3Kgamma controls multiple steps in the recruitment process. PMID: 23683463
35. PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth. PMID: 23565202
36. findings indicate PI3Kgamma-dependent suppression of cAMP signaling as a critical regulatory element of microglial phagocytosis. PMID: 23276671
37. Loss of PI3Kg is protective in the early phases of hapten-induced colitis, but loss of this signaling protein hinders the resolution of inflammation in the colon. PMID: 23282580
38. The PI3Kgamma regulates the activity of RalA, which is one of the molecular mechanisms inducing N-methyl-D-aspartate receptor-dependent long-term depression. PMID: 23433113
39. kinase-independent function of PI3Kgamma could directly inhibit GSK-3 function by preventing the PP2A-PPMT-1 interaction and that this inhibition of GSK-3 was independent of Akt. PMID: 23354687
40. Campylobacter jejuni-induced PI3K-gamma signaling mediates neutrophil recruitment and intestinal inflammation in interleukin (IL)10-deficient mice. PMID: 23180818
41. PI3Kgamma promotes development of experimental autoimmune encephalomyelitis. PMID: 23028778
42. PI3-kinase p110gamma mediates initial podocyte injury and proteinuria, both of which precede TGF-beta-mediated glomerular scarring in adriamycin nephropathy. PMID: 22534961
43. Mice lacking functional PI3Kdelta or PI3Kgamma are largely protected from experimentally induced psoriatic dermatitis and correlate with reduced interleukin (IL)-17 levels in lesions, serum, and draining lymph nodes. PMID: 23024273
44. Intranasal administration of a broad-spectrum PI3K inhibitor or a PI3Kgamma-specific inhibitor 1 h before AHR assessment attenuated IL-13 effects. PMID: 22543031
45. the knockdown of p110gamma in murine epithelial carcinoma 4T1.2 cells inhibited primary tumor growth and spontaneous metastasis, as well as lung colonization PMID: 21996737
46. p110gamma PI3K signaling regulates BCL6 expression. PMID: 22422878
47. Activation of peripheral KORs directly blocks inflammatory hyperalgesia through stimulation of the nNOS/NO signaling pathway which is probably stimulated by PI3Kgamma/AKT signaling. PMID: 22316281
48. results show that GM-CSF-differentiated murine macrophages become foam cells by fluid-phase pinocytosis of LDL and identify PI3Kgamma as contributing to this process. PMID: 22058424
49. PI3Kgamma plays a critical role in pathogenesis of chronic cutaneous leishmaniasis caused by L. mexicana. PMID: 22232690
50. Increased acidification of CpG-containing endosomes in p110gamma(-/-) cells enforces endosomal escape of CpG, which results in increased association of CpG with DNA-PKcs to up-regulate IL-10 production in macrophages. PMID: 22053215

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KEGG: mmu:30955

STRING: 10090.ENSMUSP00000062864

UniGene: Mm.101369