Recombinant Mouse Polycystin-2 (Pkd2), partial

1. Pkhd1(Flox67HA) is a valid mouse model of autosomal recessive polycystic kidney disease to track Pkhd1-derived products containing the C-terminus. Significantly, exon 67 containing the nuclear localization signal and the polycystin-2 binding domain is not essential for Fibrocystin function in this model. PMID: 28729032
2. Knocking out TRPP2 by CRISPR/Cas9 genome editing eliminated the channel current, establishing it as TRPP2 dependent PMID: 27760766
3. olycystin 2 provides a critical function in the heart, independent of renal involvement PMID: 27081851
4. The TRPP2 functionally interacts with both ryanodine and InsP3 receptors. These interactions were not similar in adult and old mice. PMID: 26254047
5. Pkd2(-/-) mice with homozygous PKD2(tg)-transgene alleles (Pkd2(-/-);PKD2(tg/tg)) showed significant further amelioration of the cystic severity compared to that in Pkd2(-/-) mice PMID: 26435415
6. Pkd1 and Pkd2 have coordinate effects on osteoblast differentiation and opposite effects on adipogenesis, suggesting that Pkd1 and Pkd2 signaling pathways can have independent effects on mesenchymal lineage commitment in bone PMID: 25464512
7. PKD2 regulates directly and indirectly about 5% of the cytotoxic T-cell phosphoproteome. PMID: 25266776
8. In inner medullary collecting duct, flow, via polycystin-2 and P2 receptors, engages Ca(2+)-dependent signaling pathways that stimulate ET-1 synthesis. PMID: 25587122
9. Pkd2(+/-) cardiomyocytes shift the beta adrenergic receptor pathway and have altered calcium handling, independent of desensitized calcium-contraction coupling. PMID: 25368166
10. Epithelial-specific disruption of Pkd2 disrupts male reproductive tract development. PMID: 24951251
11. AGT inhibition resulted in significant decreases in kidney size and cyst volume and an improvement in kidney function in mice with targeted mutation in Pkd2. PMID: 25537744
12. an epidermal growth factor activated TRPP2\TRPV4 channel may play an important role in increased cell proliferation and cystogenesis. PMID: 23977387
13. Expression of PC2 and PC1 in osteocyte-like cells is increased by oscillatory fluid flow PMID: 24268313
14. Pkd2 is likely to play a critical role in craniofacial growth as a mechanoreceptor. Pkd2 is also identified as one of the genes responsible for autosomal dominant polycystic kidney disease (ADPKD). PMID: 23390131
15. The defect in vasodilatation in Pkd2 heterozygous vessels is primarily due to a reduction in nitric bioavailability secondary to increased vascular oxidative stress. PMID: 23103499
16. these results thus suggest that nodal flow is sensed in a manner dependent on Pkd2 by the cilia of crown cells located at the edge of the node. PMID: 22983710
17. Protein kinase D2-deficient lymphocytes bound normally to integrin ligands in static and shear flow adhesion assays. They also homed normally to lymphoid organs after adoptive transfer into wild-type mice. PMID: 22311617
18. Study concludes that mechanical injury of brain endothelial cells induces a rapid influx of calcium, mediated by TRPC1 and TRPP2 channels, which leads to NO synthesis and actin cytoskeletal rearrangement. PMID: 22192412
19. polycystin-2 forms functional channels in retinal ganglion cells, of which biophysical and pharmacological properties are similar to polycystin-2 channels reported for other tissues PMID: 22155264
20. All channel-forming isoforms of TRPP channels (polycystin-2, polycystin-L, and polycystin-2L2) were expressed in adult mouse lacrimal gland. PMID: 21508103
21. findings identify PC2 and PDE4C as unique components of an AKAP complex in primary cilia and reveal a common mechanism for dysregulation of cAMP signaling in cystic kidney diseases arising from different gene mutations PMID: 21670265
22. identify PKDs, in particular PKD2, as a major mediator of muscle cell differentiation in vitro PMID: 21298052
23. Data show that PC-2 regulates FSS-induced MAP kinase trafficking into the nucleus of CD cells. PMID: 21109758
24. data suggest that TAZ and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ maintain PC2 at the level needed for proper ciliogenesis PMID: 21474562
25. Pkd1l1 is the elusive Pkd2 binding partner required for Left-Right patterning. PMID: 21307093
26. Male pkd2(WS25/-) mice consistently display a late progression in liver growth PMID: 20388629
27. PC-2 may mediate cell-cell adhesion, at least partially, through E-cadherin. PMID: 19688268
28. Pkd2ws25/- mice exhibit hepatorenal pathology resembling human autosomal dominant polycystic kidney disease. PMID: 20093497
29. Data suggest that Bicc1 functions by modulating the expression of polycystin 2 (Pkd2 by antagonizing the repressive activity of the miR-17 microRNA family on the 3'UTR of Pkd2 mRNA. PMID: 20215348
30. In Pkd2-defective liver endothelial cells, PKA-dependent ERK1/2 signaling controls HIF-1alpha-dependent VEGF secretion and VEGFR-2 signaling PMID: 19766642
31. TRPP gene is expressed in the mouse inner ear. PMID: 20095091
32. functions as a calcium-activated intracellular calcium release channel in vivo, and polycystic kidney disease results from the loss of a regulated intracellular calcium release signalling mechanism PMID: 11854751
33. role in left-right axis determination and elucidation that it acts downstream or in parallel to shh and upstream of the nodal cascade PMID: 12062060
34. localization to kidney cilia and elevation of level in polycystic kidney disease PMID: 12062067
35. PC2 functions as a plasma membrane channel in renal epithelia and may contribute to Ca(2+) entry and transport of other cations in defined nephron segments in vivo PMID: 12640140
36. polycystin-2 has a role in regulating the localization of polycystin-1 in mammalian cells PMID: 12840011
37. Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812 PMID: 14742446
38. Pericentrin, intraflagellar transport proteins, and Polycystin-2 form a complex in vertebrate cells that is required for assembly of primary cilia and possibly motile cilia and flagella. PMID: 15337773
39. Our results demonstrate a PC1-independent function of PC2 in left-right axis formation, and indirectly support a ciliary role of PC2 in this process. PMID: 16316413
40. Proliferating tubular cells were uniformly positive for Pkd2 expression in Pkd2(+/-) kidney. Pkd2 haploinsufficiency may cause an increase in cell proliferation preceding cyst formation. PMID: 16720597
41. Non-invasive phenotyping using ultrasound did not reveal significant cardiovascular difference between adult Pkd2(+/LacZ) and WT mice. PMID: 17182135
42. arterial vasculature in Pkd2(+/-) mice exhibits an exaggerated contractile response and increased sensitivity to phenylephrine. PMID: 17202419
43. These findings suggest that FPC and polycystins share, at least in part, a common mechanotransduction pathway. PMID: 17283055
44. PC2 is important for regulation of RyR2 function and that loss of this regulation of RyR2, as occurs when PC2 is mutated, results in altered Ca(2+) signaling in the heart. PMID: 17404231
45. overexpression of human PKD2 leads to anomalies in tubular function, probably due to abnormalities in tubule morphogenesis. PMID: 18048422
46. TNF-alpha, an inflammatory cytokine, disrupts the localization of polycystin-2 to the plasma membrane and primary cilia through a scaffold protein, FIP2, which is induced by TNF-alpha PMID: 18552856
47. Results suggest that polycystin-2 plays a role in centrosome duplication. PMID: 18725310
48. PC2 down-regulation is accompanied by a phenotype similar to that of Pkhd1(-/-) mice PMID: 18782757
49. Pkd2 in the ER plays a role in cellular Ca(2+) homeostasis and Stx5 functions to inactivate Pkd2 and prevent leaking of Ca(2+) from ER stores PMID: 18836075
50. ERK activation was induced by PKD2 overexpression via B-Raf signaling, providing a possible molecular mechanism of cystogenesis PMID: 19098310

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KEGG: mmu:18764

STRING: 10090.ENSMUSP00000084041

UniGene: Mm.483692