Recombinant Mouse Potassium channel subfamily K member 9 (Kcnk9), partial

1. impairment of the leak K(+) channel (Kcnk9) decreased sleep duration. Based on these results, we hypothesize that leak K(+) channels regulate sleep duration in mammals. PMID: 30224462
2. Acute hypercapnia (5% CO2) stimulated ventilation in TASK-1/3(-/-) and wild-type mice to a similar extent; however, at higher CO2 concentrations the stimulation of ventilation was more pronounced in TASK-1/3(-/-) mice. At hyperoxia (100% O2), TASK-1(-/-), TASK-3(-/-) and wild-type mice showed the physiological small decrease of ventilation. TASK-1/3(-/-) mice exhibited an abnormal increase of ventilation under hyperoxia. PMID: 28673876
3. results demonstrate that neurotensin (NT) transiently increased the neuronal excitability of dentate gyrus granule cells (GCs) by inhibiting TASK-3 channels; NT-mediated increases in neuronal excitability facilitate long-term potentiation at the perforant path-GC synapses PMID: 25405940
4. KCNK9 channels are not involved in hearing. PMID: 26549439
5. THe results of this study suggested that dysfunction of KCNK9 causes a migration defect in the cortex via an activity-dependent mechanism. PMID: 23236211
6. Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells. PMID: 24042502
7. Data indicate that in 1-day-old Task3-/- mice, renal renin concentration was lower than in wild-type mice. PMID: 23698720
8. DPP6 co-expression with TASK-3 results in the formation of a protein complex that enhances resting membrane potassium conductance. PMID: 23593319
9. An extracellular ion pathway plays a central role in the cooperative gating of a K(2P) K+ channel by extracellular pH PMID: 23319597
10. Task3 plays an important role in the adaptation of aldosterone secretion to dietary salt intake. PMID: 22878402
11. This study demonistrated that kcnk9 gene expression in mouse dorsal raphe nucleus PMID: 22534482
12. TASK3 channel genes may contribute to the development of low renin essential hypertension and idiopathic hyperaldosteronism in mice. PMID: 22493079
13. TASK channels are not required for the stimulation of aldosterone production by protons but their inhibition by physiological acidosis may contribute to full expression of the steroidogenic response. PMID: 21111026
14. Kcnk9 gene is imprinted, with preferential expression from the maternal allele in mouse brain. PMID: 17704508
15. inhibition by glucose in neurons is mediated by ion channels not previously implicated in central or peripheral glucose sensing: tandem-pore K(+) (K(2P)) channels PMID: 16731510
16. TASK3 and HCN2 channels stabilize the membrane potential by a mutual functional interactions. PMID: 16760342
17. TASK-like conductances are more prevalent in inhibitory interneurons than previously supposed. PMID: 16837582
18. Our results support a novel role for TASK genes in enhancing neuronal excitability and promoting high-frequency firing, but suggest that TASK1/3 subunits are not essential for orexin cell responses to glucose and pH. PMID: 19508695
19. TASK-3 knockout mice exhibit a slower progression from their waking to sleeping states and their sleep episodes as well as their REM theta oscillations are more fragmented. PMID: 19805135

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KEGG: mmu:223604

STRING: 10090.ENSMUSP00000038729

UniGene: Mm.386856