Recombinant Mouse Protein C-ets-1 (Ets1)

1. miR-326 may target the Ets-1 protein to contribute to iodide-induced thyroiditis, providing a new theoretical basis for the use of miRNA targeting therapy for the treatment of autoimmune diseases. PMID: 29181619
2. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center PMID: 28637900
3. data reveal ETS1 as a critical regulator of ILC2 expansion and cytokine production and implicate ETS1 in the regulation of Id2 at the inception of ILC2 development. PMID: 27069114
4. Ets1 predominantly binds distal nucleosome-occupied regions in double negative thymocytes and nucleosome-depleted regions in double positive thymocytes. importantly, Ets1 induces chromatin remodeling by displacing H3K4me1-marked nucleosomes. PMID: 26673693
5. reduced lung levels of PPARgamma and increased levels of microRNA-27a (miR-27a), v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 and E selectin). PMID: 27612006
6. data support a general model in which Ets-1 interacts with nonspecific DNA via dynamic electrostatic interactions, whereas hydrogen bonding drives the formation of well-ordered complexes with specific DNA PMID: 27362745
7. Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes. PMID: 26564177
8. Akt2 upregulates dendritic cell migration at least in part by ETS1-dependent stimulation of IP3R2 transcription. PMID: 24496246
9. The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1. PMID: 26093983
10. our data suggested that ESE1/ELF3 may promote the UC progression via accelerating NF-kappaB activation and thus facilitating IEC apoptosis. PMID: 25926267
11. maintenance of appropriate c-ets-1 levels is essential to prevent loss of self-tolerance in the B cell compartment. PMID: 26355157
12. Data indicate interactions between Ets1 transcription factor and two of its important regulators: Lyn, which maintains Ets1 expression to limit the differentiation of autoreactive plasma cells (PCs), and Btk. PMID: 26209625
13. our results demonstrate that both Ets1 and miR-155 can directly regulate the expression of CD1d on B-cells PMID: 25929465
14. Ets-1 has a role in fibronectin-derived heparin-binding domain polypeptides alleviating melanoma cell invasiveness and chemoresistance PMID: 24816403
15. MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation PMID: 24968297
16. Ets-1 overexpression is associated with invasiveness in breast cancer. PMID: 24706481
17. Data show that proto-oncogene protein Ets1 is downregulated in B cells by B cell receptor signaling. PMID: 24929000
18. Mediator of neointima formation in arteriovenous fistula PMID: 24203999
19. The aim of this study was to examine whether expression of microRNA 222 in males and females contributes to changes in the expression of eNOS. PMID: 23632416
20. Data indicate that differences between the N termini of transcription factors Ets1 and Ets2, rather than differences in the DNA binding domains, determine whether the proteins are capable of blocking antibody-secreting cells (ASCs) formation or not. PMID: 24277931
21. Ets-1 promotes the expression of IL-2 by modulating the activity of NFAT. PMID: 24019486
22. ETS1 prevents the binding of ELK3 to EBS2 at low cell density. PMID: 23708702
23. E-twenty-six (ETS) transcription factors Ets related gene (Erg) and Ets1 are the most common sites for transposon insertion in SB-induced JAK2V617F-positive erythroleukemias PMID: 23533276
24. These results suggest a critical role for Ets-1 regulation during B cell activation and cell cycle entry. PMID: 23216019
25. TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter. PMID: 22742857
26. microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway PMID: 23060436
27. Data suggest that erythroblastosis virus E26 oncogen homolog-1 (ETS-1) is a common mediator of the proinflammatory and profibrotic effects of Ang II-induced hypertensive renal damage. PMID: 22966006
28. ETS1 regulates a broad gene expression program in NK cells that promotes target cell recognition while limiting cytokine-driven activation. PMID: 22608498
29. miR-370 directly regulates BMP-2 and Ets1 expression, at the translational level, during BMP-2-stimulated cell differentiation. PMID: 22587915
30. Ets-1 is critical for IgG2a CSR and acts as an essential cofactor for Stat1 in the regulation of T-bet expression in B cells. PMID: 22438254
31. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. PMID: 22297719
32. A physical interaction between Ets-1 and histone deacetylase (HDAC)1 cooperatively downregulates interleukin (IL)-10 gene expression in T helper type (Th)1 cells. PMID: 22266280
33. The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites. PMID: 22056786
34. The unstructured N-terminus provides 10-fold uniform stabilization of the ground state ERK2*Ets*MgATP complex and intermediates of the enzymatic reaction. PMID: 21494553
35. Ets-1 directly binds to and activates the CD127 promoter and is a critical regulator of CD127 expression in T cells. PMID: 21148801
36. Data reveal that elevated expression of Ets1 has a much broader array of pro-tumorigenic effects on epithelial cells than previously appreciated. PMID: 20930145
37. Down-regulation of miR-208 in BMP-2-stimulated osteoblast differentiation is an important part of the regulatory machinery involved in early osteogenesis. PMID: 20576608
38. results suggest that Ets-1 activated by the Erk pathway promotes chondrogenic specification and p70S6k activated by both the Erk and Akt pathways plays an important role in gliogenic specification PMID: 20085809
39. the dynamic helical elements of Ets1, appended to a conserved structural core, constitute a phospho-switch that directs Ras/MAPK signaling to downstream changes in gene expression PMID: 20534573
40. Results demonstrate that Ets1 is required to direct the proper migration and differentiation of cardiac neural crest in the formation of the interventricular septum, and could play a role in the etiology of human congenital heart disease. PMID: 20356956
41. Deletion of ETS-1 causes ventricular septal defects and abnormal ventricular morphology in mice. PMID: 19942620
42. the role of antigen strength-dependent Erk1/2 activation for Ets-1-mediated collaboration with IL-12 in CD8+ T cells. PMID: 19843578
43. increase in ETS1 mRNA and protein expression after exposure to electromagnetic fields PMID: 11887334
44. identification of promoter region and binding site for Ets-1 in mouse SERCA3 PMID: 12119294
45. HIF-2alpha and Ets-1 binding is required for transcriptional activation of Flk-1 in endothelial cells PMID: 12464608
46. expression of dominant-negative mutant perturbs normal and tumor angiogenesis in a mouse ear model PMID: 12660815
47. Ets1 has a role in controlling fgl2 expression in endothelial cells PMID: 12752447
48. data suggest that p42Ets-1 acts as a distinct transcription factor from p51Ets-1 PMID: 14668797
49. Ets-1 up-regulation is involved in the development of retinal neovascularization PMID: 15111329
50. ETS-1, PEA3, and ERM have roles in regulation of caveolin-1 transcription in epithelial cells PMID: 15138262

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KEGG: mmu:23871

STRING: 10090.ENSMUSP00000034534

UniGene: Mm.292415