Recombinant Mouse Protein patched homolog 1 (Ptch1), partial

1. It is concluded that during early pseudoglandular stage of lung development Ptch1 patterns Fgf10 and regulates Foxf1 expression in the lung mesenchyme to direct branch formation and this is essential for proper lobe formation and lung function. PMID: 28939119
2. The results of the present study indicate that CHL1 triggers PTCH1-, SMO-, RhoA- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development. PMID: 28630165
3. A subset of miRNAs expression is altered in GCPs by radiation alone, and the same miRNAs were validated in spontaneous and radiation-induced medulloblastoma (MB) from Ptch1+/- mice, confirming of these miRNAs in the pathogenesis of MB. PMID: 27626168
4. during Hedgehog signaling, ligand binding inhibits Patched by trapping it in an inactive conformation, a mechanism that explains the dramatically reduced activity of oncogenic Patched1 mutants. PMID: 27647915
5. The seemingly simple, constitutive Hedgehog response of patched/Ptch1 is driven by a complex regulatory architecture, with batteries of context-specific enhancers engaged in promoter-specific interactions to tune signaling individually in each tissue, without disturbing patterning elsewhere. PMID: 27146892
6. These findings support a model in which Ptch1/2 mediate secretion of a Smo-inhibitory cholesterol precursor. PMID: 27552050
7. Ptch1 required for ductal outgrowth and proper hormone receptor expression in the mammary epithelium. PMID: 28275010
8. Thus, our study clearly demonstrated the unique involvement of the two novel PTCH1 splice variants in HH signal transduction. PMID: 28390897
9. These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modulate Ptch1 activity but are not essential for regulation of the Hh pathway. PMID: 27325696
10. Data indicate that Sonic hedgehog (Shh) stimulate branching morphogenesis (BrM) and induced synthesis of mRNAs for Ptch1 protein, epidermal growth factor (EGF) and receptors of the ErbB receptors ErbB1, ErbB2 and ErbB3. PMID: 26930157
11. Data show that the ketogenic diet does not affect growth of Ptch1+/-Trp53-/- Hedgehog (HH) pathway medulloblastoma. PMID: 26192445
12. Targeted single gene deletion of Ptch1 in mouse brain causes medulloblastoma. PMID: 26067104
13. Transcriptional upregulation of the inhibitory receptor Ptch1 regulates Shh signaling during neural tube development. PMID: 25833741
14. There was a lower degree of DNA-methylation in methylation-sensitive CpG regions of the Ptch promoter in RMS compared to normal muscle from heterozygous Ptch animals. PMID: 25823816
15. results indicate that whereas ciliary localization of Patched is essential for suppression of Smoothened activation, the primary event enabling Smoothened activation PMID: 26038600
16. Dsg2-mediated hyperproliferation, MEK/Erk1/2 activation, and accelerated squamous tumor development are enhanced on the Ptc1+/lacZ background. PMID: 25871385
17. Data show that the Hedgehog (Hh) pathway activation by either a ligand or genetic loss of the negatively acting Hh receptor Patched-1 (Ptch) reduced the affinity and frequency of signaling protein Smoothened (Smo) binding at the base. PMID: 26100903
18. Shh and transforming growth factor beta signaling cooperate to promote Ptch1-associated cataract development by activating EMT PMID: 25452120
19. Smurf-mediated endocytosis of Patched1 is required in sonic hedgehog signal reception PMID: 24925320
20. Results show that XIAP binds to the C terminus of Ptch1 and mediates the death-dependent function of Ptch1. PMID: 25292199
21. Ptc1-Gli1 signaling deregulation resulting in abnormal loss of glial precursor cells may contribute to a cognition decline in Alzheimer's disease brains. PMID: 25027328
22. Mutations in Ptch1 gene is associated with medulloblastoma. PMID: 25816987
23. Our data suggest that cutaneous macrophages and DC are necessary for tumor growth restraining processes in the Ptchflox/floxERT2+/- mouse model for Basal cell carcinoma PMID: 24691432
24. validate our model by successfully predicting expression changes of Gli1 and Ptch1 in mutants at different developmental stages and in different tissues PMID: 25458012
25. Results found that PTCH1 is highly expressed in hepatocellular carcinoma tissues. PMID: 24805933
26. These data provide novel evidence that disruption of hair follicles in Ptch(+/-) mice enhances cutaneous susceptibility to inflammation and basal cell carcinomas. PMID: 24631180
27. Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1. PMID: 24244464
28. Ptch1(-/-);Ptch2(-/-) cells cannot further activate the Shh response, demonstrating that Ptch2 mediates the response to Shh in the absence of Ptch1. PMID: 25085974
29. Our studies indicate that concomitant loss of Ptch1 and Ptch2 activity inhibits epidermal lineage specification and differentiation. PMID: 24492243
30. Patched1 is required in neural crest cells for the prevention of orofacial clefts. PMID: 23900075
31. The results depicted pancytopenic feature of peripheral blood, developmental anomaly of neutrophils, depression of primitive stem and progenitor population along with Shh, Ptch1, Smo and Gli1 expression in aplasia group PMID: 23152377
32. canonical and non-canonical Hedgehog signaling pathways acting through Ptch1 are regulated differentially by the activities of the C-terminal region of this receptor PMID: 24570001
33. Inactivation of patched 1 protein in chondrocytes led to the mice developing progressive spinal fusion with vertebral malformation. PMID: 24757136
34. study determined that DL (Dogface-like) is a hypomorphic allele of Ptch1, leading to increased Hedgehog signaling; 2 aberrant transcripts are generated by the mutated Ptch1(DL) gene, which would be predicted to reduce levels of functional Patched1 protein PMID: 23897749
35. Hh receptor Ptch is dispensable for T cell function in vitro as well as in vivo PMID: 23577186
36. PTCH1, PTCH2 and HHIP1 all contribute to ligand-dependent antagonism of sonic hedgehog signaling. PMID: 23900540
37. Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice. PMID: 23223138
38. Ptch1 and Smo are predominantly localized in the postsynaptic side of the synapses, a distribution pattern similar to that found in hippocampal neurons PMID: 22477363
39. We show that mutations in Ptch in Lysozyme M-expressing cells result in GIST-like tumors in mice. PMID: 23041331
40. elevated expression in skin, liver, and intestine of trisomic mice PMID: 22890555
41. These data demonstrate that expression of an activated allele of c-src overcomes the block to mammary gland morphogenesis in mice arising due to the loss of the cytoplasmic C-terminal domain of Ptch1. PMID: 22968113
42. Nos2 deficiency promotes medulloblastoma development in Ptch1(+/-) mice through retention of proliferating GCPs in the external granular layer due to reduced Gap43 expression PMID: 22438824
43. in both mouse and human pancreas, expression of the inhibitory Ptch1 receptor occurs in delta cells and this expression is not affected by diabetogenic treatment with STZ in mice indicating that hedgehog pathway is constitutively inactive in these cells. PMID: 22069255
44. Patched may contribute to cholesterol efflux from cells PMID: 21931618
45. Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum. PMID: 21602895
46. Data suggest that the patched1 and the pacrg-parkin-qkI loci genetically interact to regulate cilia function of the ependymal cells. PMID: 21447392
47. Although Ptc1 protein was originally thought to be restricted to cell membrane fractions, our findings suggest that its C-terminal fragments can function as an alternative signal transducer that is directly transported to the cell nucleus PMID: 21533246
48. The extra-toes spotting mouse embryos have ectopic Shh and Ptch1 expression in the anterior limb. In addition, anterior limb buds show aberrant Gli3 processing, consistent with perturbed SHH/GLI3 signaling. PMID: 21292980
49. Ptch receptor is an exclusive T lymphoid cell-extrinsic factor necessary for proper development of T cells at their prethymic stage. PMID: 21317383
50. ZNF431 directly represses Patched1 expression and likely functions to repress the hedgehog response in cells PMID: 21177534

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KEGG: mmu:19206

STRING: 10090.ENSMUSP00000021921

UniGene: Mm.228798