Recombinant Mouse Protein phosphatase 1 regulatory subunit 15A (Ppp1r15a), partial

1. Findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1 and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies. PMID: 29109149
2. established Neuro2a cells with edited GADD34 and ATF4/GADD34 genes and found that ATF4 acts as a proapoptotic factor, but GADD34 depletion did not attenuate the expression of cleaved caspase-3 induced by tunicamycin treatment. PMID: 28825160
3. In response to endoplasmic reticulum stress, activation of PERK coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis. PMID: 27802424
4. GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation. PMID: 27171261
5. Translation arrest is further demonstrated to be key for anti-viral response by acting synergistically with MAVS activation to amplify TBK1 signaling and IFN-beta mRNA transcription, while GADD34-dependent protein synthesis recovery contributes to the heterogeneous expression of interferon observed in dsRNA-activated cells. PMID: 28100675
6. Results highlighted the essential roles played by GADD34 and CReP in regulating mRNA translation during unstressed conditions and following endoplasmic reticulum stress. PMID: 27161320
7. Sustained protein synthesis sensitized cells to pharmacological induction of the Unfolded Protein Response (UPR), and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress. PMID: 27129771
8. Through aging or a high fat diet, insulin signaling in GADD34-deficient liver converted to be down regulated compared with WT mice. PMID: 26316333
9. Results show that GADD34 plays a vital role in promoting cell death following proteasome inhibition via enhancing protein synthesis involved in endoplasmic reticulum stress, reactive oxygen species production and autophagy formation. PMID: 26408692
10. avidity for the substrate plays an important role in imparting specificity on the PPP1R15B-PP1G-actin ternary complex. PMID: 25774600
11. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS combined with amino acid deprivation through regulation of mTOR signaling pathway in macrophages. PMID: 25659802
12. GADD34 upregulated pro-inflammatory mediator. PMID: 26196182
13. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2. PMID: 26041779
14. GADD34 expression was upregulated in the liver of mice after exposure to a carcinogen, diethylnitrosamine (DEN). In both acute and chronic DEN treatment models, GADD34 deficiency not only decreased oncogene expression, but also reduced hepatic damage. PMID: 25832002
15. Thus these results indicate that GADD34 appears to suppress myofibroblast differentiation through inhibiting Smad3-dependent TGFbeta signal pathway and promote its apoptosis by activating caspase-3 pathway PMID: 25210702
16. GADD34 works to inhibit the proliferation and differentiation of HSCs or myeloid precursor cells and maintains homeostatic differentiation of neutrophil-lineage cells to avoid early immunological senescence. PMID: 24247289
17. Data indicate that GADD34 is the regulatory subunit of rotein phosphatase-1 (PP1) to specify PP1 to dephosphorylate TGF-beta-activated kinase 1 (TAK1) Ser412. PMID: 24534530
18. Traumatic brain injury induces the expression of GADD34 by stimulating binding of a stress inducible transcription factor, ATF4, to the GADD34 promoter. PMID: 23907468
19. GADD34 phosphorylation on tyrosine 262 modulates endoplasmic reticulum stress signaling and cell fate. PMID: 24092754
20. Data indicate that ATF4/GADD34 and p90ATF6 expression gradually changed, and the levels of cleaved caspase-3 were significantly increased with repetitive cycles of testicular hyperthermia. PMID: 23611781
21. study demonstrates that GADD34 is absolutely required for type I-IFN and IL-6 production by embryonic fibroblasts in response to dsRNA PMID: 22615568
22. GADD34 was shown to be required for normal cytokine production both in vitro and in vivo. PMID: 22315398
23. starvation-induced Gadd34 suppresses mTOR and, thereby, induces autophagy. PMID: 21439266
24. GADD34 negatively regulates cell migration in wound healing via expression of myosin IIA. PMID: 20625881
25. observations indicate that GADD34 controls a programmed shift from translational repression to stress-induced gene expression, and reconciles the apparent contradiction between the translational and transcriptional arms of cellular stress responses PMID: 12606582
26. The function of GADD34 is a recovery from a shutoff of protein synthesis induced by endoplasmic reticulum stress. PMID: 12824288
27. Results describe the effects of GADD34 on p53 phosphorylation and p21/WAF1 transcription. PMID: 14635196
28. an equilibrium state exists between Gadd34 and the opposing heme-regulated inhibitor kinase EIF-2alpha during hemoglobin synthesis in the reticulocyte PMID: 16478986
29. During conditions of cell stress, GADD34 forms a stable complex with tuberous sclerosis complex (TSC) 1/2, causes TSC2 dephosphorylation, and inhibits signaling by mammalian target of the rapamycin (mTOR). PMID: 17273797
30. GADD34 contributes to the regulation of p21 expression, and it suppresses cellular proliferation through the induction of cellular senescence. PMID: 17487408
31. GADD34 induced by VSV infection suppresses viral replication via mTOR pathway inhibition, indicating that cross talk between stress-inducible GADD34 and the mTOR signaling pathway plays a critical role in antiviral defense PMID: 17670836
32. GADD34 gene restored virulence in HSV1716, suggesting that HSV virulence, rather than increased GADD34, exacerbated ischaemic damage. PMID: 17928799
33. GADD34 translation is regulated by a unique 5'UTR uORF mechanism to ensure proper GADD34 expression during eIF2alpha phosphorylation PMID: 19131336
34. Ppp1r15a mutant mice are superficially indistinguishable from wild type; Ppp1r15b(-/-) mouse embryos survive gestation but exhibit severe growth retardation and impaired erythropoiesis, and loss of both Ppp1r15 genes leads to early embryonic lethality PMID: 19181853
35. The gadd34 and gadd153 proteins were localized in the nonepithelial cells and not induced in the cancer epithelial cells of the selenium-treated carcinomas. PMID: 19276161

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KEGG: mmu:17872

STRING: 10090.ENSMUSP00000049488

UniGene: Mm.4048