Recombinant Mouse Prothrombin (F2)

1. These results suggested that the thrombinstimulated synthesis of IL6 was limited by HSP90 in osteoblasts, and that the effects of HSP90 were exerted at the point between Rhokinase and p38 MAPK. PMID: 30066835
2. Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation. PMID: 28409836
3. These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes. PMID: 28489922
4. mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success. PMID: 27252233
5. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin PMID: 26748875
6. thrombin/PAR-1 interaction regulated MCP-1, TF, MCSF and IL-6 production. PMID: 26475502
7. Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin nanoparticle therapeutics. PMID: 26769047
8. Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization. PMID: 26457757
9. Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen. PMID: 26238780
10. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon. PMID: 26350460
11. thrombin/PAR1 pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke. PMID: 25604482
12. High Factor IIa expression is associated with multiorgan pathologies in sickle cell disease. PMID: 26286849
13. Blockage of thrombin exosites with compounds specific for exosite I (hirudin and HD1 aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP-thrombin interaction, indicating a 2-site binding mechanism. PMID: 26045608
14. Fyn, but not Lyn, was required for complete Pyk2 phosphorylation by thrombin. PMID: 25967238
15. Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment. PMID: 25112870
16. The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. PMID: 24790104
17. Influenza virus H1N1 activates platelets through FcgammaRIIA signaling and thrombin generation. PMID: 24665136
18. These results indicate that thrombin acts through multiple mechanisms to activate MMPs and PGE2 synthesis in amnion. PMID: 24652285
19. Suggest a thrombin-dependent mechanism of complement activation by red blood cell-microvesicles independent of the classical, lectin, or alternative pathway. PMID: 24311376
20. thrombin induces monocyte/macrophage migration via PAR1-Galpha12-dependent Pyk2-mediated Gab1 and p115 RhoGEF interactions, leading to Rac1- and RhoA-targeted Pak2 activation. PMID: 24025335
21. Micro-computed tomography analysis of distal tibia metaphyses also revealed for the first time a major impact of the FVIII/thrombin/PAR1 axis on the dynamic bone structure. PMID: 23982175
22. PKCalpha and Akt modulate platelet function by phosphorylating and inhibiting GSK3alpha/beta, thereby relieving the negative effect of GSK3alpha/beta on thrombin-mediated platelet activation. PMID: 23239877
23. Mast cell restricted mouse and human tryptase.heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen. PMID: 22235124
24. Recombinant thrombomodulin domains 2 and 3 protein significantly reduces atherosclerosis and neointima formation through its thrombin-binding ability. PMID: 21840881
25. Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. PMID: 21724997
26. Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo PMID: 21531712
27. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. PMID: 21436072
28. Localization and expression of prothrombin in rodent osteoclasts and long bones. PMID: 21191574
29. platelet STIM1 and Orai1 have roles in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation PMID: 20519511
30. Hirudin preconditioning of vWF-deficient mice attenuated processing of infused rpvWF suggesting that thrombin plays a part in the processing events in vivo. PMID: 11776313
31. effect of hirudin treatment indicates endogenous thrombin contributes to tumor implantation, seeding, and spontaneous metastasis PMID: 15265791
32. mouse thrombin lacks Na+ activation but retains high catalytic activity PMID: 16428384
33. beta(3) integrin, thrombin, and Ca(2+) play critical roles in platelet aggregation without fibrinogen or VWF PMID: 16824188
34. Thrombin and MMP-9 collaborate to promote neuronal death in culture and in intracerebral hemorrhage (ICH). PMID: 17021183
35. findings indicate thrombin plays a major role in extraintestinal thrombus formation associated with experimental colitis PMID: 18772359
36. thrombin-induced p65/RelA, AMPK, and PKCdelta activation were markedly reduced by knockdown of the TRPC isoform TRPC1 expressed in human endothelial cells and in endothelial cells obtained from Trpc4 knock-out mice. PMID: 18990707
37. formation of thrombin through the procoagulant activity of FVIII is necessary to induce costimulation for the immune response to FVIII treatment PMID: 19794141

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KEGG: mmu:14061

STRING: 10090.ENSMUSP00000028681

UniGene: Mm.89048