F2

F2, or prothrombin, is a vitamin K-dependent plasma glycoprotein synthesised in the liver. It is produced by the liver and is a key component in the coagulation cascade that culminates in the conversion to active thrombin.The mechanism of action of F2 involves its activation during coagulation.When F2 is activated by the complex of factor Xa and factor Va, it is converted to thrombin (F2a), a serine protease that catalyzes the conversion of fibrinogen to insoluble fibrin to form a thrombus and achieve hemostasis. achieve haemostasis. In addition, thrombin is involved in platelet activation and vasoconstriction, further facilitating the hemostatic process.

F2 is an important factor in maintaining blood mobility and preventing bleeding. It not only plays a role in physiological haemostasis, but also plays a key role in pathological thrombosis, such as deep vein thrombosis and atherosclerosis, etc. Abnormal activity or imbalance in the regulation of F2 has been associated with a variety of coagulation disorders and thrombotic disorders, and therefore it is an important target for blood coagulation research and anticoagulation therapy.