Recombinant Mouse Ras GTPase-activating-like protein IQGAP1 (Iqgap1), partial

1. over-expression of IQGAP1 in human head and neck squamous cell carcinoma may indicate poor prognosis. PMID: 29846864
2. Alterations in IQGAP1 signalling promote the emergence of cancer stem cells and gastric adenocarcinoma development in the context of an H. pylori infection. PMID: 27729612
3. propose that the GRD and CT domains regulate IQGAP1 localization to retracting actin networks to promote a tumorigenic role in melanoma cells PMID: 29240845
4. Data highlight a unique mechanism of formin action in which mDia1 and INF2 function in series to stabilize MTs and point to IQGAP1 as a scaffold that facilitates the activation of one formin by another. PMID: 27030671
5. Hectd1 regulates the protein level of IQGAP1 through ubiquitination. PMID: 28073378
6. Loss of IQGAP1 results in impaired insulin signaling and glucose homeostasis in vivo. PMID: 28082684
7. IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma. PMID: 26464624
8. IQGAP1 has the potential to modulate airway contraction severity in acute asthma. PMID: 25271629
9. we propose that IQGAP1 acts as a small GTPase scaffolding platform within the small GTPase network, and recruits and/or regulates small GTPases, small GTPase regulators and effectors to orchestrate cell behavior PMID: 24355937
10. This finding has new implications for involvement of IQGAP1 in cell polarization and migration events and potentially in cell cycle-associated nuclear envelope assembly/disassembly. PMID: 22964981
11. IQGAP1 contributes to AngII-induced apoptosis of podocytes by interacting with the ERK1/2 signaling protein PMID: 24247724
12. RSPO-LGR4 not only induces the clearance of RNF43/ZNRF3 to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt signaling complex. PMID: 24639526
13. IQGAP1 is upregulated in pre-existed sparing neurons of the CA1 layer undergoing morphological changes after excitoxicity-induced hippocampal CA3 neuronal death. PMID: 23907317
14. activation of Cdc42 in response to the insulin secretagogue glucose recruits endocytic machinery to IQGAP1 at the cell periphery and regulates endocytosis at this membrane site. PMID: 24100016
15. IQGAP1 has an essential role in RAS-driven tumorigenesis in mouse and human tissue PMID: 23603816
16. Review. IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density. PMID: 23018238
17. IQGAP1 localized to the endothelial cell-cell junction after sphingosine-1-phosphate (S1P) treatment. PMID: 22561460
18. Phosphoinositide module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)). PMID: 22493426
19. our data suggest that IQGAP1 acts as a dual negative regulator in T cells, limiting both TCR-mediated activation kinetics and F-actin dynamics via distinct mechanisms. PMID: 22573807
20. [review] IQGAP1 possesses multiple protein interaction motifs to achieve its scaffolding functions in this summary of recent developments and exciting new findings of cellular functions of IQGAP1. PMID: 22345702
21. These results suggest that DGKzeta is involved in IQGAP1/Rac1-mediated phagocytosis upon LPS stimulation in macrophages. PMID: 22450320
22. the scaffolding function of IQGAP1, which integrates Rac1 and MAPK signalling, is usurped by Salmonella during cell invasion PMID: 21851337
23. On the basis of these findings, we propose that a dysfunctional IQGAP1 gene contributes to the cognitive deficits in brain disorders characterized by fewer dendritic spines. PMID: 21653857
24. Upon activation, Rap1b colocalized with the scaffolding protein IQGAP1. PMID: 20733035
25. IQGAP1 is a potential target protein of S100B during processes of dynamic rearrangement of cell membrane morphology PMID: 12377780
26. IQGAP is potential regulator of E-cadherin-catenin interactions during murine preimplantation development PMID: 12617831
27. IQGAP1 has a fundamental role in cell motility and invasion PMID: 12900413
28. IQGAP1 is an important modulator of normal hemostasis PMID: 15026422
29. in motile cells beta-catenin is recruited by IQGAP1 and N-cadherin to active membrane ruffles, wherein beta-catenin mediates the internalization and possible recycling of the membrane-associated proteins N-cadherin and APC PMID: 17255093
30. VEGF synthesized by astrocytes could be involved in the guidance of neural progenitors to neurogenic niches and that IQGAP1 is an effector of the VEGF-dependent migratory signal PMID: 17460084
31. Iqgap1 modulates activation of B-RAf. PMID: 17563371
32. Dia1 and Iqgap1 interact in cell migration and phagocytic cup formation. PMID: 17620407
33. Development of hepatocellular carcinoma in Iqgap2-deficient mice is Iqgap1 dependent. PMID: 18180285
34. IQGAP1 associates and co-localizes with the exocyst-septin complex, and influences the localization of the exocyst and the organization of septin. PMID: 18216334
35. The site-specific expression pattern of this potent modulator of multiple biological pathways in the renal tubules suggests that IQGAP1 may have multiple important roles in various renal functions. PMID: 18413651
36. the scaffold protein IQGAP1 couples Ca(2+) and calmodulin signaling to B-Raf function PMID: 18567582

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KEGG: mmu:29875

STRING: 10090.ENSMUSP00000128278

UniGene: Mm.207619