Recombinant Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Atp2a2), partial

1. Pin1 serves as a modulator of SERCA2a and Na(2+)/Ca(2+) exchanger 1 Ca(2+) handling proteins, with loss of function resulting in impaired cardiomyocyte relaxation. PMID: 29018025
2. Pep2.5 prevented the down-regulation of SERCA2 expression in a) murine heart samples obtained from mice with sepsis and b) in cardiomyocytes exposed to serum from septic shock patients. Thus, we speculate that Pep2.5 may be able to prevent down-regulation of cardiac SERCA2 expression in patients with sepsis. PMID: 27853260
3. The findings support a salutary role of TLR9 in some subsets of HF conditions and underline the importance for future studies on the mechanisms of TLR9 in diastolic HF. PMID: 28490840
4. Our results indicate that changes in cell shape changed nuclear morphology and then the gene expression of IP3R1 and SERCA2, which produced different intracellular calcium transient patterns. PMID: 28962833
5. VMP1 modulates SERCA2 activity to control endoplasmic reticulum contacts for autophagosome formation. PMID: 28890335
6. Nevertheless, the functional role of protein serotonylation in controlling SAN automaticity is largely unexplored. In this study, we screened the cardiomyocytes proteins and found that sarco(endo)plasmic reticulum Ca ATPase type 2a (SERCA2a) can be serotonylated. Simulation studies using mathematical SAN cell model showed that variation of Ca(2+) affinity of SERCA2a pump cause either tachycardia or bradycardia. PMID: 27780728
7. Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2+)storage and SERCA activity, ultimately affecting denervated skeletal muscle function. PMID: 26825123
8. Generated were mice harboring N-ethyl-N-nitrosourea (ENU)-induced allelic mutations in Serca2: three missense mutations and one nonsense mutation. Mice harboring these Serca2 mutations developed tumors that were categorized as either early onset squamous cell tumors (SCT), with development similar to null-type knockout mice [2,4] (aggressive form; M682, M814), or late onset tumors (mild form; M1049, M1162). PMID: 27131742
9. Identify Atrap as a novel regulatory protein of the cardiac Ca(2+)-ATPase SERCA2a. Suggest that Atrap enhances the activity of SERCA2a and, consequently, facilitates ventricular relaxation. PMID: 27015675
10. Sustained activation of Toll-like receptor 9 causes cardiac and systemic inflammation, and deterioration of SERCA2a depletion-mediated diastolic heart failure. PMID: 26461521
11. The LRP1/Pyk2 axis represses SERCA2 mRNA expression via HIF-1a. PMID: 25968337
12. This first-in-class small-molecule activator targeting SERCA2a SUMOylation may serve as a potential therapeutic strategy for treatment of heart failure PMID: 26068603
13. privileged signal communication between the beta1-adrenergic receptor and SERCA2a impaired in cardiac hypertrophy PMID: 25917898
14. These data reveal myofibrillar Ca(2+)-sensitivity to be an important determinant of the cardiac effects of SERCA2 haploinsufficiency and raise the possibility that Darier disease patients are more susceptible to heart failure under certain conditions. PMID: 26064889
15. SEPN1 enhances SERCA2 activity by reducing luminal cysteines that are hyperoxidized by ERO1-generated peroxides. PMID: 25452428
16. SERCA 2 and ERO1 mediate endothelial cell and macrophage angiogenic response to ischemia/hypoxia. PMID: 25260714
17. AMPK directly relaxes vascular smooth muscle cell by a decrease of [Ca(2+)]i. This is achieved by calcium sequestration via SERCA activation, as well as activation of BKCa channels. PMID: 26034200
18. The results of this study indicate that post-translational modifications of SERCA2a caused by the toxic environment of the hypertrophied and failing myocardium can be prevented by SUMO-1. PMID: 24893265
19. ERK activation is sufficient to reduce SERCA2 mRNA. PMID: 25008120
20. The promoter regions of the SERCA-2A and beta-MHC genes, Atp2a2 and Myh7, respectively in murine hearts after one or eight weeks of pressure overload induced by transverse aortic constriction, were evaluated. PMID: 25181347
21. AMPKalpha2 influences the regulation of SERCA2a mRNA in type I skeletal muscle fibers following exercise training PMID: 24876362
22. Expression of sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) 2, phospholamban, ryanodine receptor 2 and calsequestrin 2 was significantly decreased in 28- versus 10-week-old CryalphaB R120G transgenic mice. PMID: 24825000
23. miR-151-3p directly targets ATP2a2, a gene encoding for a slow skeletal and cardiac muscle specific Ca(2+) ATPase, SERCA2 thus downregulating slow muscle gene expression. PMID: 25200835
24. Sphingosine 1-phosphate is a novel regulator of SERCA2 that activates CaMKII signaling and mediates adiponectin-induced cardioprotection. PMID: 24852843
25. Suggest Pak1 is required to maintain ventricular Ca(2+) homeostasis and electrophysiological stability and implicate Pak1 as a novel regulator of cardiac SERCA2a through a transcriptional mechanism. PMID: 25217043
26. Results indicate sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) as a transcriptional target of Pancreatic and duodenal homeobox protein 1 (Pdx-1). PMID: 25271154
27. High fat high sucrose diet upregulated Nox2, induced inflammation, increased irreversible SERCA oxidation, and suppressed the response of aortic SERCA to nitric oxide. PMID: 24631774
28. Nox2 targets SERCA in response to a high fat high sugar diet. PMID: 24704899
29. TLR9 stimulation reduces SERCA2 activity, modulating calcium handling between the sarcoplasmic/endoplasmic reticulum and mitochondria. PMID: 24610369
30. hind limb muscle ischemia induced S-glutathione adducts on SERCA2 in both whole muscle tissue and endothelial cells PMID: 24920669
31. ex vivo function of isolated SERCA2 KO hearts is severely impaired PMID: 24223976
32. SERCA2b is one of the molecules that maintains endoplasmic reticulum calcium levels during oscillations. PMID: 24101727
33. Long-term levosimendan treatment improves both contractility and relaxation in a heart-failure model with marked diastolic dysfunction due to reduced calcium transients in Serca2 knockout mice. PMID: 24072410
34. Reduced cardiomyocyte SERCA2 activity leads to mechanical dysfunction and also energetic dysfunction. PMID: 24486508
35. I-1 and sarco/endoplasmic reticulum Ca2+ -ATPase synergistically induce the vascular smooth muscle cell contractile phenotype. PMID: 24249716
36. increased beta-adrenergic stimulation is a potentially highly significant compensatory mechanism by which cardiac function is maintained in Serca2 KO mice PMID: 23528094
37. MAPKAPK-2 and MAPKAP-3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function. PMID: 23608535
38. Enhanced myocardial contractility in PDE3A-knockout hearts increased sarcoplasmic reticulum calcium ATPase type 2a activity. PMID: 23168336
39. The important role of SAR in maintaining Ca(2+) transport activity of SERCA2a and cardiac function in the senescent population, is reported. PMID: 22119571
40. These findings suggest that local changes in Ca(2+) homeostasis may play an important signaling role in phospholamban-SERCA double knockout mice, perhaps due to reduced microdomain Ca(2+) buffering by SERCA2b. PMID: 22505640
41. functional interactions of SERCA2b and Bcl-2 in the cell may be modulated by HSP70 and other chaperones and stress-regulated proteins. PMID: 22360692
42. analysis of extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout PMID: 22355118
43. Aggregation of SERCA2 mutant protein induced endoplasmic reticulum stress and apoptosis in keratinocytes. PMID: 22045735
44. Data suggest that the CaMKIIdeltaB-induced imbalance between NCX1 and SERCA2 is partially responsible for the disturbance of intracellular Ca(2) homeostasis and the pathological process of heart failure. PMID: 21931829
45. Sex differences affected the response of myocardial tissues in dealing with cardiac endoplasmic reticulum stress in part through the regulation of SERCA2, CHOP, Ire1alpha and TRAF2. PMID: 20850991
46. This study evaluated the role of SERCA2b and SERCA3 in the control of the free calcium concentration in the endoplasmic reticulum and the role of SERCA3 in the control of insulin secretion. PMID: 21885870
47. data show that SUMOylation is a critical post-translational modification that regulates SERCA2a function, and provide a platform for the design of novel therapeutic strategies for heart failure PMID: 21900893
48. We show that in cultured embryonic cardiomyocytes hypoxia (1% O(2)) induce time-dependent downregulation of SERCA2a expression. PMID: 21382378
49. In ventricular cardiomyocytes with reduced SERCA2 abundance, Ca(2+) wave development following beta-adrenergic stimulation is potentiated. PMID: 21242164
50. Results suggests that reduced SERCA2 abundance or function may contribute to the phenotype of heart failure also through induction of endoplasmic reticulum/sarcoplasmic reticulum stress responses. PMID: 20965565

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KEGG: mmu:11938

STRING: 10090.ENSMUSP00000031423

UniGene: Mm.227583