Recombinant Mouse Serine/threonine-protein kinase PAK 4 (Pak4)

1. PAK4 crystal structures can be classified into specific conformational groups, and that these groups are associated with previously unobserved hinging motions and an unusual conformation for the kinase hydrophobic core. Our findings therefore indicate that there may be a diversity of kinase hinging motions, and that these may indicate different mechanisms of regulation. PMID: 28993291
2. PAK4 microparticles may have a role in the ventilation-induced lung injury process PMID: 28261612
3. These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast-related disorders. PMID: 25640698
4. PAK4 promotes alpha-MSH/UVB-induced melanogenesis via the CREB and Wnt/beta-catenin signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders. PMID: 25560280
5. PAK4 phosphorylates Par6B at Ser143 blocking its interaction with Cdc42. PMID: 25662318
6. Defined here is the overlap in phosphopeptides regulated by K-Ras, Cdc42, and PAK4; perturbation of these signaling components affects phosphoproteins associated with microtubule depolymerization, cytoskeletal organization, and the cell cycle. PMID: 23608596
7. These results indicate that PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart PMID: 22173944
8. p21-activated kinase 4 regulates regulatory myosin light chain phosphorylation and myosin contractility during FcgammaR-mediated phagocytosis. PMID: 21907820
9. the transient increase in PAK4 levels at early G1 reduces p21 levels, thereby abrogating the activity of CDK4/CDK6 kinases, and allowing cells to proceed with the cell cycle in a precisely coordinated way PMID: 21381077
10. Conditional Pak4 knockout mice were born normally, but displayed growth retardation and died prematurely. The brains showed a dramatic decrease in proliferation of cortical and striatal neuronal progenitor cells. PMID: 21382368
11. results suggest that overexpression of Pak4 triggers events that are important for the transformation of mammary epithelial cells PMID: 20697354
12. PAK4 interacts with KGF receptor and mediate anti-apoptosis effects of KGF on epithelial cells. PMID: 12529371
13. PAK4 has a role in neural tube development PMID: 14517283
14. PAK4 can negatively regulate the activation of Rho through a direct protein-protein interaction with G protein-linked Rho GEFs PMID: 14625312
15. PAK4 mediates morphological changes through regulation of GEF-H1 PMID: 15827085
16. Pak4-induced arrest is mediated by a pathway that requires the ERK mitogen-activated protein kinase, as well as the cell cycle inhibitors p16(INK4) and p19(ARF; expression levels are upregulated in response to stimuli that promote senescence PMID: 16227603
17. PAKs may represent a target for various neurotoxic protein oligomers, and signaling deficits may contribute to the behavioral defects in chronic neurodegenerative diseases. PMID: 17883396
18. Pak4 may play a vital role in a wide range of different types of cancer. PMID: 18644984
19. pneumolysin selectively induced expression of MKP1 via a TLR4-dependent MyD88-TRAF6-ERK pathway, which inhibited the PAK4-JNK signaling pathway,leading to up-regulation of MUC5AC mucin production PMID: 18782768
20. Pak4 protein kinase has an essential role in extraembryonic tissue development and vessel formation PMID: 19464366

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KEGG: mmu:70584

STRING: 10090.ENSMUSP00000032823

UniGene: Mm.21876