Recombinant Mouse Steroid hormone receptor ERR2 (Esrrb)

1. The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs. PMID: 29129686
2. Taken together these observations suggest that ESRRbeta is a critical component in the onset of Ddilated cardiomyopathy by affecting contractility and calcium balance PMID: 28130335
3. Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3, and Dax1 inhibited activities of Esrrb and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells. PMID: 27601327
4. mitotic Esrrb binding is highly dynamic, driven by specific recognition of its DNA-binding motif and is associated with early transcriptional activation of target genes after completion of mitosis PMID: 27723719
5. JARID2 physically interacts with ESRRB, SALL4A, and PRDM14 PMID: 26523946
6. interacts in trophoblast stem cells with the histone demethylase Lsd1 and with the RNA Polymerase II-associated Integrator complex PMID: 26206133
7. The forced expression of Essrb (and Nanog) resulted in the dispensability of nucleostemin expression in embryonic stem cells. PMID: 25522312
8. Daily regulation of Esrrb in photoreceptor cells may contribute to their adaptation to 24-h changes in metabolic demands. PMID: 25737630
9. Loss of Errbeta affects body composition, neuropeptide levels, stress hormones, and centrally-modulated startle responses of mice. PMID: 24053666
10. Esrrb selective deletion in the hindbrain alters neuropeptide Y expression, whole-body energy level and ingestive behavior. PMID: 23360481
11. Dax1 functions as a negative regulator of Esrrb and Oct3/4, and these molecules form a regulatory loop for controlling the pluripotency and self-renewal capacity of embryonic stem cells. PMID: 23508100
12. a direct Nanog target gene that can substitute for Nanog function in pluripotent cell PMID: 23040477
13. a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal PMID: 23040478
14. Esrrb forms a heterodimer complex with Sox2 in ES cells to regulate transcriptional differences between mouse embryonic and epiblast stem cells. PMID: 23169531
15. we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERRbeta) is a candidate marker for slow motor neurons in the spinal cord PMID: 20437528
16. ERRbeta is a critical regulator of rod photoreceptor function and survival PMID: 20534447
17. Data demonstrate that estrogen-related receptor (ERR) beta is transiently induced, and ERRgamma is dramatically induced (and accumulates) in a differentiation-dependent manner in skeletal muscle cells. PMID: 19631715
18. estrogen receptor beta knockout females exhibit lordosis behaviour equal to that of wild-type females PMID: 12969243
19. ERbeta was predominantly localized in the magnocellular divisions of PVN. In the pregnant female brain. andcirculating sex steroids may differentially regulate the expression of ERbeta in the PVN of mice. PMID: 14715153
20. Loss of primordial germ cells-specific expression of ERR-beta results in reduction of germ cell number in mouse embryos PMID: 15003627
21. Nr3b2 controls epithelial cell fate and endolymph production by the stia vascularis. PMID: 17765677
22. Esrrb is recruited near the Oct-Sox element in the Nanog proximal promoter, where it positively regulates Nanog expression. PMID: 18662995
23. Esrrb coordinates with Nanog and Oct4 to activate the internal machinery of ES cells PMID: 18957414
24. In ES cells, Esrrb targets many genes involved in self-renewal and pluripotency. This suggests that Esrrb may mediate reprogramming through the upregulation of ES-cell-specific genes. PMID: 19136965

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KEGG: mmu:26380

STRING: 10090.ENSMUSP00000105833

UniGene: Mm.235550