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Yeast-expressed T-cell surface glycoprotein CD3 epsilon chain (Cd3e) CSB-YP004931MO is a recombinant fusion protein of partial Cd3e coupled to a 6xHis-tag at the N-terminus. This protein consists of the extracellular domain (23-108aa) of mouse Cd3e and has a calculated molecular weight of 11.9 kDa. Its identity was validated by the LC-MS/MS analysis. The SDS-PAGE showed an observed Cd3e protein molecular mass of about 14.5-16 kDa. The purity of this protein is over 90%. In-stock Cd3e proteins are offered now. Except for specific antibody synthesis, this recombinant Cd3e protein also may be used in the Cd3e-related immunology studies.
Cd3e, together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex has a vital role in coupling antigen recognition to several intracellular signal-transduction pathways. Cd3e is essential for T-cell development. Deficiencies of Cd3e lead to immunodeficiency. It is also related to the susceptibility of type I diabetes in women.
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We are interested in item CSB-YP004931MO. For the current lot, would you please tell me the buffer before the product was lyophilized? What do you recommend for reconstitution?
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