Recombinant Mouse TNF receptor-associated factor 1 (Traf1)

1. this study shows that Traf1 gene knock-out mice show increased susceptibility to lipopolysaccharide-induced septic shock PMID: 27893701
2. NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1), TNF receptor-associated factor 2 (TRAF2), cellular inhibitor of apoptosis (cIAP2), and Ferritin heavy chain (FTH1) were increased following Losartan treatment PMID: 25766329
3. TRAF1 is a crucial early mediator of hepatic ischemia/reperfusion injury. PMID: 25321474
4. Increased neuronal TRAF1 leads to elevated neuronal death and enlarged ischaemic lesions. PMID: 24284943
5. The pathogenesis of spontaneous KRN/I-A(g7) arthritis can largely proceed by TRAF1-independent pathways. PMID: 23354839
6. Together, these findings define the importance of the basal phosphorylation state of the TRAF1 Serine 139 residue in coordinating signalling events downstream of 4-1BB in primary T cells. PMID: 23376065
7. TRAF1 plays a critical role in regulating T cell activation both through restricting the costimulation independent activation of NIK in activated T cells and by promoting the 4-1BB-induced classical NF-kappaB pathway. PMID: 22570473
8. These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 T cell fitness during the chronic phase of disease and a target for therapy. PMID: 22184633
9. combined signaling from the TNF or IL-1 receptors promotes maximal lung inflammation that may contribute to the severity of disease caused by H5N1 virus infection PMID: 20815704
10. TRAF1 deficiency attenuates atherogenesis in mice, most likely owing to impaired monocyte recruitment to the vessel wall PMID: 20421522
11. TRAF1 reglates the subcellular localization and reveals mechanism of TRAF2 signaling. PMID: 12370254
12. TRAF1 limit the induction of Th2 responses by decreasing NIP45 concentration to the nucleus down-regulating the expression of NIP45-dependent IL-4 gene transcription. PMID: 16352630
13. cellular levels of TRAF1 may play an important role in modulating the degradation of TRAF2 and TRAF3 in response to signals from the TNFR superfamily PMID: 16622006
14. The TRAF1 signaling axis is critical for CD8 memory T cell survival in vivo. PMID: 17116875
15. Results implicate endothelial TRAF-1, -2, -3, -5, and -6 in CD40 signaling in atherogenesis, identifying these molecules as potential targets for selective therapeutic intervention. PMID: 17332487
16. The expression of TRAF1 in resident lung cells is required for the development of asthma. PMID: 18209085
17. TRAF1 has a prosurvival effect in CD8 T cells via the 4-1BB-mediated up-regulation of anti-apoptosis regulatory protein Bcl-x(L) and extracellular-regulated MAP kinase (ERK)-dependent Bim apoptosis facilitator down-modulation. PMID: 18523273

Show More

Hide All

KEGG: mmu:22029

STRING: 10090.ENSMUSP00000028234

UniGene: Mm.239514