TRAF1 Research Reagents

TNF receptor-associated factor 1 is a protein in humans that is encoded by TRAF1 gene. Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

The following TRAF1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TRAF1 Antibodies

TRAF1 Antibodies for Homo sapiens (Human)

TRAF1 Proteins

TRAF1 Proteins for Mus musculus (Mouse)

TRAF1 Proteins for Homo sapiens (Human)

TRAF1 ELISA Kit

TRAF1 ELISA Kit for Homo sapiens (Human)

TRAF1 Background

TNF receptor-associated factor 1 is a protein in humans that is encoded by the TRAF1 gene. TRAF1 protein is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with and mediate the signal transduction from various receptors of the TNFR superfamily. TRAF1 and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of TRAF1 can be induced by the Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins. This interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.

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