Recombinant Mouse Telomeric repeat-binding factor 2 (Terf2)

1. shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging PMID: 28437249
2. Selective inactivation of Terf2 in neural progenitors induced apoptosis, resulting in a complete loss of the brain structure. PMID: 28620865
3. The authors propose that TRF2 masks and stabilizes the t-loop three-way junction, thereby protecting telomeres from detrimental deletions and PARP1 activation. PMID: 28805810
4. TRF2, a component of shelterin, binds to core histones to protect chromosome ends from inappropriate DNA damage response and loss of telomeric DNA. The N-terminal Gly/Arg-rich domain (GAR domain) of TRF2 directly binds to the globular domain of core histones. PMID: 27514743
5. Overexpressing TRF2-S and silencing FMRP promotes mRNA entry to axons and enhances axonal outgrowth and neurotransmitter release from presynaptic terminals. PMID: 26586091
6. TRF2 binds and transactivates the promoter of the angiogenic tyrosine kinase platelet-derived growth factor receptor beta (PDGFRbeta). PMID: 25437559
7. role of TRF2 in skin homeostasis, is reported. PMID: 24725274
8. shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1 PMID: 24469404
9. We concluded that genomic instability resulting from loss of TRF2 expression provides biological advantages to the cancer stem cell population PMID: 23178498
10. Conditional deletion of individual components of shelterin showed that TRF2 was required for the formation and/or maintenance of t-loops, whereas deletion of TRF1, Rap1, or the POT1 proteins (POT1a and POT1b) had no effect on the frequency of t-loop occurrence. PMID: 24120135
11. TAF7L associates with TRF2 both in vitro and in testis, suggesting that TAF7L likely cooperates directly with TRF2 at promoters of a subset of postmeiotic genes to regulate spermiogenesis. PMID: 24082143
12. Experiments in cells from knockout mice showed that uPAR controls the ubiquitin-proteasome system in VSMC & regulates doxorubicin-induced TRF2 ubiquitination and proteasomal degradation via this mechanism. PMID: 23172421
13. the molecular properties of TRF2 that are both necessary and sufficient to protect chromosome ends in mouse embryonic fibroblasts: the data support a two-step mechanism for TRF2-mediated end protection PMID: 23389450
14. TRF2 provides a crucial link between telomere function and ultraviolet-induced damage repair, whose alteration underlies genomic instability, cancer and aging. PMID: 16142233
15. PARP1 associates with telomere repeat binding factor 2 (TRF2) and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to telomeric DNA. PMID: 16436506
16. with overexpressing the TRF2 telomere-binding protein, mice show short telomeres in the presence of telomerase activity, leading to premature aging and increased cancer PMID: 16582635
17. TRF2 and POT1 act independently to repress two DNA damage response pathways; TRF2 represses ATM, whereas POT1 prevents activation of ATR PMID: 17687332
18. The inactivation of TRF2ts at 37 degrees C was rapid and reversible, permitting induction of short periods (3-6 h) of telomere dysfunction in the G0, G1, and S/G2 phases of the cell cycle. PMID: 18451109
19. These findings indicate a previously unnoticed role for TRF2 in the assembly of telomeric chromatin. PMID: 18971622
20. the TRF2 telomeric protein has a role in telomere-associated diseases in mouse epidermal stem cells PMID: 19259387

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KEGG: mmu:21750

STRING: 10090.ENSMUSP00000118759

UniGene: Mm.6402