Recombinant Mouse Transcription activator BRG1 (Smarca4), partial

1. Study using conditional Brg1 knockout mice showed that Brg1 interacted with and was recruited by SREBP1c to the promoters of SREBP target genes and optimized the chromatin structure to facilitate SREBP1c binding. Therefore, a previously unrecognized role for Brg1 in hepatic lipid metabolism by portraying Brg1 as an essential epigenetic co-factor for SREBP1c was identified. PMID: 29857051
2. Brg1 expression is up-regulated by pro-non-alcoholic steatohepatitis stimuli in vitro and in vivo. Hepatocyte-specific Brg1 deletion alleviates non-alcoholic steatohepatitis in mice. PMID: 29890136
3. results suggest that miR-144-3p contributes to OGD/R-induced neuronal injury in vitro through negatively regulating Brg1/Nrf2/ARE signaling. PMID: 29457851
4. Data found that Brg1 played important roles in hair cells (HCs) intrinsic polarity maintenance, anchoring outer hair cells base to the Deiter's cells and scar formation of the auditory epithelium. These results demonstrated a requirement for Brg1 activity in development and suggested a role for Brg1 in the proper cellular structure formation of HCs. PMID: 27255603
5. HDAC9, in cooperation with BRG1 and MALAT1, mediates a critical epigenetic pathway responsible for vascular smooth muscle cells dysfunction. PMID: 29520069
6. The results demonstrated that restoration of Brg1 during reperfusion could enhance Nrf2-mediated inducible expression of HO-1 during hepatic ischemia-reperfusion injury to effectively increase antioxidant ability to combat against hepatocytes damage. PMID: 28569786
7. BAF (BRG1/BRM-Associated Factor) chromatin-remodeling complex may adaptively respond to ethanol exposure to protect against a complete loss of miR-9-2 in fetal neural stem cells. PMID: 28438527
8. Chromatin accessibility at OCT4-bound sites requires the chromatin remodeller BRG1, which is recruited to these sites by OCT4 to support additional transcription factor binding and expression of the pluripotency-associated transcriptome. PMID: 28287392
9. Data (including data from studies using knockout mice) suggest that Brg1 is phosphorylated by casein kinase 2 (Ck2; Ck2alpha1 and Ck2alpha-prime are catalytic subunits) in proliferating skeletal myoblasts; Brg1 is catalytic subunit of SWI/SNF chromatin-remodeling enzymes; Ck2-mediated phosphorylation of Brg1 appears to regulate myoblast proliferation. (Brg1 = Brahma-related gene 1 protein) PMID: 28939766
10. BRG1 is a SOX10 co-activator, required to establish the melanocyte lineage and promote expression of genes important for melanocyte function. PMID: 28431046
11. n keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF, Rad21 and chromatin remodeler Brg1. In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF, Rad21 and Brg1 in keratinocytes PMID: 28863138
12. Data demonstrate that Brg1 plays an essential role in development and homeostasis, including morphogenesis, stem cell differentiation and cell survival in the duodenum. PMID: 27510977
13. Point mutations in SMARCA4 (also known as BRG1) mapping to the ATPase domain cause loss of direct binding between BAF and PRC1. PMID: 27941795
14. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity. PMID: 28729363
15. RB is necessary for the recruitment of the BRG1 ATPase to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination PMID: 27940962
16. Cdx members interact with the SWI-SNF complex and make direct contact with Brg1, a catalytic member of SWI-SNF. Both Cdx2 and Brg1 co-occupy a number of Cdx target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci. PMID: 28082674
17. BRG1/BRM and c-MYC have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene in cancer. PMID: 28232072
18. Results provide insights into the mechanisms by which Brg1 functions, which is in part via the p53 program, to constrain gene expression and facilitate rapid embryonic growth. PMID: 27185875
19. Brg1 promotes neurogenic radial glial progenitor cell specification but is dispensable for neuronal differentiation PMID: 27067865
20. SWI/SNF chromatin remodeler subunits Brg1 and Brm are expressed differentially during drug-induced liver injury and regeneration in a mouse model. PMID: 27097303
21. these findings described a role for BRG1 and BRM in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte PMID: 27039070
22. show that epigenetic chromatin remodeling (via a Brg1 and p53/p21-dependent process) determines the aNSCs and progenitor maintenance and responsiveness of neurogenesis. PMID: 26418130
23. The stress-induced Brg1-G9a/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals. PMID: 26952936
24. MITF interacts with BRG1 to promote GATA4 expression in cardiac hypertrophy. PMID: 26388265
25. SMARCA4 is involved in the TOP1 recruitment to general chromatin, which suppresses transcription-associated genomic instability. PMID: 26842758
26. the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated. PMID: 26571505
27. Brg1 may play a critical role in neuronal growth by regulating the NR2B-NR2A switch in the postnatal cortex PMID: 26133793
28. Brg1 has a role in coordinating multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma PMID: 26628093
29. The data suggest that BRG1 governs Nanog expression via a dual mechanism involving histone deacetylation and nucleosome remodeling. PMID: 26416882
30. SmarcA4 is required for synapse development and myocyte enhancer factor 2-mediated synapse remodeling PMID: 26459759
31. integrates two antagonistic calcium-dependent signalling pathways that control myogenic differentiation PMID: 26081415
32. dispensable in multiple models of postnatal angiogenesis but required for vascular integrity PMID: 25904594
33. Endocardial Brg1-deficient mouse embryos develop thickened and disorganized semilunar valve cusps PMID: 26100917
34. MITF-BRG1 interplay thus plays an essential role in transcription regulation in melanoma. PMID: 25803486
35. Brg1 functions as a positive regulator for cellular proliferation and survival of primary myoblasts via pax7. PMID: 26036967
36. abnormalities in Brg1 function result in defects associated with neurodevelopmental disorders and autism PMID: 25929186
37. Brg1 inhibits the dedifferentiation that precedes neoplastic transformation, thus attenuating tumor initiation PMID: 25792600
38. Data indicate that Smarca4 protein (Brg1) acts at multiple developmental stages to orchestrate B cell development. PMID: 25985234
39. Our results highlight potential therapeutic value of targeting Brg1 and serve as a proof of concept that targeting the cells of origin of cancer may be of therapeutic relevance. PMID: 25010414
40. This study show here that loss of Smarcb1 and Smarca4 leads to severe proliferation deficits of granule neuron precursors and a hypoplastic cerebellum. PMID: 25274825
41. Genome-wide maps of SMARCA4 binding in multiple embryonic mouse tissues reveale tissue-specific in vivo association of SMARCA4 with both active and repressive distant-acting regulatory sequences. PMID: 24752179
42. Brg1 is dispensable for the survival and function of the progenitor and differentiated cells in the murine intestinal epithelium, it is essential for the maintenance of the stem cell population in a tissue-specific manner. PMID: 23922304
43. Data suggest that Brg1 and Brm integrate various proinflammatory cues into cell adhesion molecule transactivation in endothelial injury. PMID: 23963727
44. Brg1 provides the crucial epigenetic link to hypoxia-induced CAM induction and leukocyte adhesion that engenders endothelial malfunction and pathogenesis of hypoxic pulmonary hypertension. PMID: 24042015
45. Elevated levels of BRG is associated with leukemia. PMID: 24478402
46. Brg1 is a determinant of context-dependent Kras-driven pancreatic tumorigenesis. PMID: 24561622
47. A SMARCA2-containing residual SWI/SNF complex underlies the oncogenic activity of SMARCA4 mutant cancers. PMID: 24421395
48. in epidermal stem cells, p63 regulates the expression of Brg1, which binds to distinct domains within the epidermal differentiation complex and is required for relocation of the epidermal differentiation complex towards the nuclear interior. PMID: 24346698
49. SWI/SNF enzymes cooperate with SOX10 to directly activate genes that encode components of peripheral myelin. PMID: 23874858
50. Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice. PMID: 23281043

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KEGG: mmu:20586

STRING: 10090.ENSMUSP00000096547

UniGene: Mm.286593