Recombinant Mouse Transcription factor AP-2 gamma (Tfap2c)

1. TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK pathway, further supporting differentiation of glycogen cells by activating the AKT pathway PMID: 26811378
2. these findings indicate that a reduction in the gene dosage of placental Tfap2c leads to morphological changes in the labyrinth at midgestation PMID: 26063869
3. TFAP2C regulates tumorigenesis, cell growth and survival in HER2-amplified breast cancer through transcriptional regulation of EGFR. PMID: 25772240
4. Tcfap2c acts in a hierarchy to facilitate blastocyst formation through transcriptional regulation of core genes involved in tight junction assembly, fluid accumulation and cellular proliferation PMID: 23136388
5. Transcription factor AP-2gamma induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage. PMID: 25858457
6. we characterize the cis-regulatory organization of a large genomic locus consisting of Tfap2c and Bmp7. We show that this locus is structurally partitioned into two distinct domains by the constitutive action of a discrete transition zone PMID: 25569170
7. mice with a heterozygous deletion of the TFAP2C target gene Nanos3 are also prone to develop teratomas. These data highlight TFAP2C as a critical and dose-sensitive regulator of germ cell fate. PMID: 23967156
8. Tcfap2c is not required for Oct4 silencing in mouse blastocysts, but may be necessary for the maintenance of Oct4 expression during the 8 cell-to-morula transition. PMID: 23741512
9. results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells[review] PMID: 22560121
10. study demonstrated clearly that nuclear expression of transcription factor Ap-2gamma is a useful marker for identifying undifferentiated male germ cells PMID: 21654158
11. In intestine, Tcfap2c induced cellular hyperplasia and suppressed terminal differentiation indicating that Tcfap2c serves as a repressor of differentiation and inducer of proliferation. PMID: 21779369
12. Expression of AP-2gamma transcription factors in breast cancer cells supports proliferation and contributes to chemo- and radiation-resistance of tumor cells by impairing the ability to induce apoptosis. PMID: 20459791
13. AP-2gamma is functionally involved in branching morphogenesis of the mammary epithelium, possibly by controlling genetic processes downstream of ovarian hormones PMID: 20131354
14. Data suggest that Tcfap2c and Cdx2 cooperate to override the pluripotency program and establish the extraembryonic trophoblast maintenance program in murine embryos. PMID: 20404091
15. important effector of Prdm1 activity that is required for primordial germ cell maintenance PMID: 19776388
16. AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
17. Transcription factor gene AP-2 gamma essential for early murine development PMID: 11940672
18. essential in the extra-embryonic lineages for early postimplantation development PMID: 12015300
19. we have identified a potential trophoblast cell-specific regulatory element located 6 kb upstream of the murine AP-2gamma gene transcription start site, and that Sp1 and Sp3 bind to cis-regulatory elements located in the promoter proximal region PMID: 12801994
20. Our results suggest a role of AP-2 transcription factors in the maintenance of a proliferative and undifferentiated state of cells, characteristics not only important during embryonic development but also in tumorigenesis. PMID: 14573793
21. These results document an important role for AP-2 gamma in skin development, and reveal the existence of regulatory factors that can compensate for AP-2 gamma in its absence. PMID: 18353300
22. AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex. PMID: 19749747
23. Mice overexpressing AP-2gamma in the mammary epithelial cells display hyperproliferation counterbalanced by enhanced apoptosis leading to hypoplasia. In males, differentiation of seminal vesicles was impaired. PMID: 14573793
24. Activating protein-2 assumes the role of steroidogenic factor-1 in the placenta and thereby mediates the transcription of cholesterol side-chain cleavage cytochrome p450. PMID: 12145340

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KEGG: mmu:21420

STRING: 10090.ENSMUSP00000129922

UniGene: Mm.3629