Recombinant Mouse Transcriptional activator GLI3 (Gli3)

1. 5'Hoxd genes and Gli3 are part of an interdigital signalling centre that sets net Bmp signalling levels from different interdigits to coordinately regulate phalanx and joint formation. PMID: 27713395
2. Gli3 is a suppressor of stem cell proliferation that affects the number and function of mature taste cells, especially Tas1r3+ cells, in adult posterior tongue. PMID: 29415007
3. Gli3 activity in mouse thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4(+) CD8(+) to CD4(+) CD8(-) single-positive (SP4) cells in the fetal thymus and Gli3 represses Shh constitutive deletion of Gli3, and conditional deletion of Gli3 from TECs, reduced differentiation to SP4, whereas conditional deletion of Gli3 from thymocytes did not. PMID: 29361554
4. loss of Spop, but not Spopl, disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop-mediated protein degradation in mouse skeletal development; overexpressed Spop targets both Gli3FL and Gli3R for ubiquitination and degradation and Spop is an important positive regulator of Ihh signaling and skeletal development PMID: 27930311
5. mutual interactions between Gli3, Wnt8b, and Fgf17 are crucial elements of the balance between these factors thereby conferring robustness to the patterning process PMID: 26656997
6. Results demonstrate a negative role of Spop in the level and activity of Gli3, Shh signaling and ventral spinal cord patterning. PMID: 28412462
7. These results suggest that Tctn1, Tctn2, and Tctn3 are functionally divergent with respect to their role in ciliogenesis and Hedgehog signaling but conserved in neural tube patterning and Gli3 processing. PMID: 28800946
8. Results indicate that the transcription factor Gli3 (Gli3)-mutant fetal liver (FL) had increased sonic hedgehog (Shh) signaling resulting in decreased B cell development. PMID: 28533268
9. Our findings show how Nestin drives hedgehog pathway-driven cancers and the tumor-promoting effects of Nestin were mediated by binding to Gli3, a zinc finger transcription factor that negatively regulates hedgehog signaling. PMID: 27496710
10. Gli3 gene is a direct target for repression by Tgifs during the neural tube patterning. PMID: 27924807
11. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 processing. PMID: 27720745
12. T-box3 interacts with Kif7 and is required for normal stoichiometry and function of a Kif7/Sufu complex that regulates Gli3 stability and processing. PMID: 27046536
13. In Six2-positive nephrogenic progenitors, GLI3 repressor decreased progenitor cell proliferation reducing the number of nephrogenic precursor structures in the Pallister-Hall syndrome mouse model. PMID: 26604140
14. miR-378a-3p suppresses activation of hepatic stellate cells by targeting Gli3 and its expression. PMID: 27001906
15. Gli3 affects LOT positioning and target area innervation through controlling the development of the piriform cortex. PMID: 26509897
16. These data demonstrate that GLI3 processing is a major outcome of primary cilia function in dorsal telencephalon morphogenesis. PMID: 26071364
17. Disruption of the SUFU-GLI-SOX10 regulatory loop disrupts migration of neural crest cells and development of the enteric nervous system in mice. PMID: 26261006
18. Results showed that the Thr396 residue of Sufu is specifically required for regulation of Gli3 but not Gli2 implying a novel Sufu-mediated mechanism in which Gli2 activator and Gli3 repressor are differentially regulated. PMID: 25760946
19. Findings emphasize the importance of Gli3 in regulating the transition from neocortex to piriform cortex which has major implications for corticofugal axon pathfinding as this affects the size of the entry zone of corticofugal axons into the striatum PMID: 24014668
20. This study identified a critical role of the Sall4-Gli3 system at the early steps of limb development for proper development of the appendicular skeletal elements. PMID: 25848055
21. A role for Gli3R as a mediator of niche establishment and provide insights into the conditions required for proper subventricular zone neurogenic niche formation. PMID: 25127137
22. we show that the Gli3 hypomorphic mouse mutant Polydactyly Nagoya (Pdn) displays agenesis of the CC and mislocation of the glial and neuronal guidepost cells PMID: 23042737
23. Hox genes control, in a dose-dependent manner, the type of ossification (long versus short bone) of the limb skeletal elements and this function is mediated at least in part through the modulation of the Gli3 repressor function. PMID: 24930703
24. Gli3 specifies a cortical environment permissive to the growth of cortical axons at the progenitor level by controlling the formation of subplate neurons. PMID: 22903314
25. Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis. PMID: 24044950
26. Kif3a controls nephron number via distinct cell lineage-specific mechanisms. PMID: 23762375
27. VLK plays a role in the Indian hedgehog /GLI3 interactions and that Vlk and Gli3 cooperate to regulate long bone development PMID: 23792766
28. Sonic Hedgehog patterns the anterioposterior limb primarily through the inhibition of Gli3 repressor formation. PMID: 23644062
29. Primary cilia and the regulation of Gli activity are necessary for the normal expansion of the cerebral cortex during neural development. PMID: 21976438
30. Gli3 recruitment to cilia tips was reduced and Sufu/Gli3 dissociation was impaired PMID: 23026747
31. Collectively, these data strongly suggest that we have identified a set of direct Wnt target genes in the developing hippocampus and provide inside into the genetic hierarchy underlying Wnt-regulated hippocampal development. PMID: 22235033
32. study demonstrates that Zic3 and Gli3 expression overlap in developing limbs and that Zic3 converts Gli3 from repressor to activator in vitro; results indicate two Gli superfamily members that cause disparate human congenital malformation syndromes interact genetically PMID: 22234993
33. AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells. PMID: 22535956
34. Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/beta-catenin signaling in the presumptive forebrain and confirm its previously proposed role in patterning the anterior neural plate. PMID: 21452227
35. differential involvement of Gli3 explains the variation in phenotype among Gli3(Xt-J/Xt-J) mammary rudiments, and may help to understand the variation in numbers and positions of mammary glands among mammals PMID: 22046263
36. Data show that in Shh;Gli3 mutants, adjacent rings of Fgf8 and Wnt3a expression are induced in the diencephalon at the ZLI, reminiscent of the Fgf8/Wnt1-expressing isthmic organizer. PMID: 21925158
37. The extra-toes spotting mouse embryos have ectopic Shh and Ptch1 expression in the anterior limb. In addition, anterior limb buds show aberrant Gli3 processing, consistent with perturbed SHH/GLI3 signaling. PMID: 21292980
38. Introduction of a Gli3 mutant allele encoding the short form of Gli3 into Ftm mutants rescues both telencephalic patterning and olfactory bulb morphogenesis, despite the persistence of cilia defects. PMID: 21490064
39. Gli3 is required for maintaining the cortical progenitors in active cell cycle, suggesting that cells may acquire differentiated status as they turn off Gli3 expression during neurogenesis. PMID: 21525285
40. A phylogenetic analysis of the Gli3 locus that uncovered a novel regulatory element, HCNE1, is reported. PMID: 21262763
41. GLI3 and Hh signaling controls Kit and Hcn3 expression and ureter peristalsis PMID: 21339645
42. Data demonstrate that SuFu controls cerebellar patterning and cell differentiation in a GLI3 repressor-dependent manner. PMID: 21289193
43. Gli3 null mice showed craniosynostosis of the lambdoid sutures and increased osteoprogenitor proliferation and differentiation. PMID: 20570969
44. We conclude that correct Gli3 levels are particularly important for the lateral ganglionic eminence's growth, patterning, and development of axon guidance capabilities. PMID: 20943929
45. relationship between mutation points of GLI3 & Gli3 & resulting phenotypes in humans & mice described; discussed how reduced amounts of GLI3 protein or truncated mutant GLI3 protein disrupt development of limbs, head, face [review] PMID: 20201963
46. Data show that the species of Gli3 that accumulates at cilium tips is full-length and likely not protein kinase A phosphorylated. PMID: 20154143
47. interaction between Gli3 and Suppressor of Fused (Sufu) regulates the formation of either repressor or activator forms of Gli3 PMID: 20360384
48. GLI3 repressor controls nephron number by regulating ureteric tip cell expression of Wnt11 and Ret PMID: 19809516
49. Gli2 and Gli3 collectively mediate all major aspects of Ihh function during endochondral skeletal development PMID: 19906844
50. High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion. PMID: 11773971

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KEGG: mmu:14634

STRING: 10090.ENSMUSP00000106137

UniGene: Mm.5098