Recombinant Mouse Triggering receptor expressed on myeloid cells 2(Trem2),partial

1. The present study provide novel evidence that overexpression of TREM2 protects against MPTP-induced PD progression via modulation of microglial function through inhibiting TRAF6/TLR4-mediated activation of the MAPK and NF-kappaB signaling pathways. PMID: 29407460
2. Our data establish a critical link between oAbeta1-42, a major pathological component of Alzheimer's disease and TREM2 PMID: 29587871
3. These data suggest that the Alzheimer's disease-associated TREM2 R47H variant increases risk for Alzheimer's disease by conferring a loss of TREM2 function and enhancing neuritic dystrophy around plaques. PMID: 29859094
4. Data indicate a novel role for PS1 in regulating TREM2 intracellular trafficking and pathophysiological function. PMID: 29611543
5. whereas complete TREM2 deficiency protected against tau-mediated microglial activation and atrophy, TREM2 haploinsufficiency elevated expression of proinflammatory markers and exacerbated atrophy at a late stage of disease. The differential effects of partial and complete loss of TREM2 on microglial function and tau pathology PMID: 30232263
6. TREM2 plays a crucial role in altering the proinflammatory M1 microglia to M2 phenotype and has beneficial effects in the immune pathogenesis of Parkinson's disease. PMID: 29621548
7. Overexpression of TREM2 downregulated the levels of IL-1beta, ameliorated T396 expression, inhibited the activity of GSK-3beta, and improved sickness behavior. Increased Arg1 expression and a high level of synaptophysin were also observed in the transgenic mice following TREM2 overexpression. PMID: 29689568
8. These studies of the role of TREM2 in neuroinflammation and neurodegeneration suggest that impairing microglial TREM2 signaling reduces pure tauopathy. PMID: 29073081
9. This article suggests a potential explanation of why TREM2-deficient microglia are unable to respond to neurotoxic plaques in the Alzheimer's disease brain and highlight a further need to understand microglial biology. PMID: 28978423
10. TREM2 protects against cerebral ischemia/reperfusion injury through the aspect of post-ischemic inflammatory response and neuronal apoptosis. PMID: 28592261
11. Results suggest that TREM2 plays a critical role in inflammation and neuronal cell survival and in neurogenesis. Study showed that TREM2 is a soluble protein transported by macrophages through ventricle walls and choroid plexus, and then enters the brain parenchyma via radial glial cells. TREM2 protein is essential for neuroplasticity and myelination. A lack of TREM2 protein may accelerate aging. PMID: 27662313
12. TREM2 deficiency influences both acute and chronic responses to traumatic brain injury, with altered macrophage response early on and improved functional outcome at later time points. PMID: 26976047
13. A central role of TREM2 is in the regulation of microglia response to acute neurotoxic insults. PMID: 28189343
14. Loss of TREM2 reduces the ability of microglia to engulf amyloid beta-peptide. PMID: 27402340
15. TREM2 and TREML2 play opposite roles in microglia activation. PMID: 27143430
16. Our study suggests that Vps35/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to Alzheimer disease. PMID: 27717139
17. sTREM2 plays a crucial role in regulating microglial cell survival and inflammatory responses. PMID: 28209725
18. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism. PMID: 28802038
19. This study demonstrate a critical role of TREM2-mediated Wnt/beta-catenin pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival. PMID: 28077724
20. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor of the TREM family and is expressed on activated macrophages, immature dendritic cells, osteoclasts, and microglia. PMID: 28398927
21. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation PMID: 27196974
22. TREM2 deficiency has opposing effects on Alzheimer's disease-related pathologies at early and late stages of disease progression. PMID: 28100745
23. TREM2 protects from Alzheimer's disease by enabling microglia to surround and alter Abeta plaque structure, thereby limiting neuritic damage. PMID: 27091843
24. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 and DAP12, both of which are expressed by microglia and have bee PMID: 27798193
25. The authors demonstrate that a TREM2 loss-of-function mutation causes brain-wide metabolic alterations pointing toward a possible function of microglia in regulating brain glucose metabolism. PMID: 28559417
26. flow cytometry analyses indicated significantly lower surface expression of T66M TREM2 variant than wild type or other TREM2 variants PMID: 28490631
27. Study found that TREM2 was upregulated in the brain of P301S mice, an animal model of tau pathology, during disease progression and showed that TREM2 overexpression rescued spatial cognitive impairments and ameliorated neuropathologies including neuronal and synaptic loss as well as tau hyperphosphorylation. PMID: 26802771
28. This study showed that TREM-2 deficiency restricts the inflammatory response, thereby decreasing organ damage and mortality. PMID: 27253382
29. TREM2 attenuates tau kinase activity through restriction of neuroinflammation, and thus protects against tau pathology. PMID: 26364736
30. TREM2 is involved in prion-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion infections. PMID: 25816748
31. These findings provide a novel interpretation of Brucella intracellular growth through inhibition of NO production produced by TREM-2-mediated activated macrophages. PMID: 25563793
32. TREM-1/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role. PMID: 25860078
33. These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage PMID: 25631124
34. TREM-2 has a protective effect on inflammatory response of endotoxin-induced acute lung injury in mice. PMID: 24916365
35. results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses. PMID: 25957402
36. Corpus callosum microglia normally expand with age, but aged Trem2(-/-) mice had fewer microglia with an abnormal morphology which failed to amplify transcripts indicative of activation, phagocytosis, and lipid catabolism in response to myelin damage. PMID: 25893602
37. Data (including data from studies using knockout mice) suggest that TREM2 is expressed on alveolar macrophages and lung mucosa and plays role innate immunity during pneumococcal pneumonia; knockout of TREM2 increases phagocytosis and survival. PMID: 24945405
38. viral replication increases lung macrophage levels of intracellular and cell surface TREM-2, and this action prevents macrophage apoptosis PMID: 25897174
39. TREM2 knockdown reduced microglial activation, decreased phagocytosis of injured neurons and worsened stroke damage. PMID: 25716838
40. Upon infection with Escherichia coli, the otherwise beneficial effect of an exaggerated early immune response in TREM-2(-/-) animals was counteracted by a 50% reduction in bacterial phagocytosis. PMID: 25477281
41. important role for TREM2 in inflammatory macrophages and neuroinflammation PMID: 25732305
42. TREM2 detects damage-associated lipid patterns associated with neurodegeneration, sustaining the microglial response to beta-amyloid accumulation. PMID: 25728668
43. TREM2 promotes adipogenesis and diet-induced obesity by upregulating adipogenic regulators in conjunction with inhibiting the Wnt10b/beta-catenin signaling pathway. PMID: 25114293
44. It may play a protective role against aging-related neuroinflammation and cognitive impairment. PMID: 24368090
45. These data suggest that TREM2 is important for the microglial response to Amyloid-beta deposition PMID: 24893973
46. Results suggest that an epigenetic mechanism involving an aluminum-triggered, NF-kB-sensitive, miRNA-34a-mediated down-regulation of triggering receptor expressed in myeloid cells 2 (TREM2) expression may impair phagocytic responses. PMID: 23778113
47. TREM-2-mediated bacterial killing is dependent on the activation of PI3K/Akt signaling. PMID: 24383713
48. TREM2 protein is expressed only in microglia/macrophages and is developmentally downregulated in a region-dependent manner. PMID: 23977213
49. TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. PMID: 24218563
50. Trem-2 plays an important role in the host defense response to sepsis by enhancing bacterial clearance. PMID: 23721075

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KEGG: mmu:83433

STRING: 10090.ENSMUSP00000024791

UniGene: Mm.261623