Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11)

1. Genetic or pharmacologic inactivation of SHP2 promotes accumulation of JAK2 phosphorylated at Y570, reduces JAK2/STAT3 signaling, inhibits TGFbeta-induced fibroblast activation and ameliorates dermal and pulmonary fibrosis. PMID: 30108215
2. These findings identify Shp2 in podocytes as a significant contributor to the signaling events following LPS challenge and suggest that inhibition of Shp2 in podocytes may present a potential therapeutic target for podocytopathies. PMID: 28352079
3. Loss of Shp2 within radial glia resulted in cortical dysplasia with decreased ERK signaling and was associated with glial defects and impaired sensorymotor development of newborn mice. PMID: 29257282
4. yolk sac erythromyeloid progenitors expressing mutant PTPN11 demonstrate functional and molecular features of juvenile myelomonocytic leukemia but do not cause disease following transplantation nor following unperturbed development. PMID: 28975680
5. nuclear Shp2, rather than cytosolic Shp2, promotes the ERalpha transcription activity. This function is achieved by enhancing the Src kinase-mediated ERalpha tyrosine phosphorylation, which facilitates ERalpha binding to Pgr promoter in an ERK-independent manner in periimplantation uteri. PMID: 28424251
6. HIF1A dependent wound healing angiogenesis in vivo can be controlled by site-specific lentiviral magnetic targeting of SHP2. PMID: 28434868
7. High SHP2 expression prevents colitis-associated cancer development. PMID: 27582544
8. T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated colonic cancer in mice. PMID: 27935860
9. Here the authors demonstrate a central role of Ptpn11 in postnatal myogenesis of mice. Loss of Ptpn11 drove muscle stem cells out of the proliferative and into a resting state during muscle growth. This Ptpn11 function was observed in postnatal but not fetal myogenic stem cells. Furthermore, muscle repair was severely perturbed when Ptpn11 was ablated in stem cells due to a deficit in stem cell proliferation and survival. PMID: 28463680
10. a method that allows the localized visualization of oxidized intermediates of SHP-2 protein-tyrosine phosphatase inside cells during signaling. PMID: 28878211
11. NO controls the calcium signal propagation through Cx37-containing gap junctions. The tyrosine phosphatase SHP-2 is the essential mediator and NO target. PMID: 29025706
12. These results suggest that SHP-2-via association with ICAM-1-mediates ICAM-1-induced Src activation and modulates VE-cadherin switching association with ICAM-1 or actin, thereby negatively regulating neutrophil adhesion to endothelial cells and enhancing their transendothelial migration. PMID: 28701303
13. Inactivation of ALX4/Alx4 causes lacrimal gland aplasia in both human and mouse. These results reveal a key role of Alx4 in mediating FGF-Shp2-FGF signaling in the neural crest for lacrimal gland development. PMID: 29028795
14. Ptpn11 gain-of-function mutations are associated with myeloproliferative neoplasm. PMID: 27840422
15. aberrant SHP2 signaling during cardiac development leads to congenital heart disease and adult-onset heart hypertrophy PMID: 27348588
16. Data suggest that phosphorylation of Shp2/Ptpn11 at Tyr542 and its translocation to postsynaptic compartment are integral processes in synaptic scaling/homeostasis; Shp2 phosphatase activity is critical to regulation of Ser(P)845 GluA1 and surface expression of GluA1 during synaptic scaling. (Shp2/Ptpn11 = protein tyrosine phosphatase non-receptor type 11; GluA1 = glutamate receptor ionotropic Ampa1 [alpha 1]) PMID: 28768764
17. data suggested that deletion of Shp2 impaired IL-25 production in bronchial epithelial cells in vitro, but might yet have minor influence on OVA-induced allergic reaction in vivo PMID: 28481957
18. The effects of SHP2 overexpression and inhibition on fibroblast response to profibrotic stimuli were analyzed in in the bleomycin model of lung fibrosis by SHP2-lentiviral administration in transgenic mice carrying a constitutively active SHP2 mutation. Mice carrying the Noonan syndrome-associated SHP2 mutation were resistant bleomycin induced pulmonary fibrosis. PMID: 27736153
19. Data show aberrant neuronal activity-induced signaling and regulation of gene expression in protein tyrosine phosphatase, non-receptor type 11 (Ptpn11D61Y) mutation and suggest that these deficits contribute to the pathophysiology of cognitive impairments in Noonan syndrome (NS). PMID: 28346493
20. This study indicates that Shp2 is required to orchestrate macrophage function and regulate host innate immunity against pulmonary bacterial infection. PMID: 27330052
21. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells. PMID: 27422603
22. SHP-2 is functionally important for the maintenance of appropriate barrier function and host-microbiota homeostasis in the large intestine. PMID: 27100271
23. This study reveals the critical contribution of Ptpn11 mutations in the bone marrow microenvironment to leukaemogenesis and identifies CCL3 as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy in Noonan-syndrome-associated leukaemias. PMID: 27783593
24. SHP2 is a potential positive regulator of eosinophil differentiation, and inhibition of SHP2 specifically in myeloid cells eventually alleviates eosinophilic airway inflammation. PMID: 27054330
25. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis. PMID: 25919282
26. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies PMID: 26265072
27. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs. PMID: 26365186
28. SHP2 activity is elevated in astrocytes isolated from glioblastoma multiforme (GBM)-prone H-Ras(12V) knock-in mice. PMID: 26617336
29. find that Shp2 is distributed to the kinetochore, centrosome, spindle midzone, and midbody PMID: 26755576
30. Mouse podocytes lacking Shp2 do not develop foot process spreading when subjected to podocyte injury in vivo using protamine sulfate or nephrotoxic serum. PMID: 26644409
31. Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice. PMID: 25289670
32. SHP2 silencing in P815 mouse mastocytoma cell line harboring KITD814Y mutation results in impaired signaling to ERK, Btk, Lyn and STAT5 pathways, and reduced rates of cell growth and colony formation. PMID: 25026279
33. Shp2 regulates IEC homeostasis through activation of Ras and thereby protects against the development of colitis. PMID: 24675817
34. Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis. PMID: 24088816
35. Overexpression of Shp2 increased the size of atrioventricular endocardial cushion by 80% at mid-gestation. PMID: 25359717
36. Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition. PMID: 25650089
37. SHP2 activation offers the pulmonary endothelium protection against barrier permeability mediators downstream of the FAK signaling pathway. PMID: 25317600
38. Loss of Shp2 is associated with osteopetrosis. PMID: 25593124
39. Together these data reveal a mechanism by which SHP-2 mediates the activation of Syk in response to fungal infection. PMID: 25915733
40. Shp2 contributes to regulation of Erk activation and synaptic plasticity in postmitotic forebrain neurons and thereby controls locomotor activity and memory formation. PMID: 25713104
41. SHP2 mutation is associated with LEOPARD syndrome and confers leanness and protection from diet-induced obesity in a mouse model PMID: 25288766
42. Shp2 associates with FRS2alpha and promotes the receptor activation and signal relay to several pathways. PMID: 24981838
43. SHP2 activation is upregulated with trichomide A, a natural cyclodepsipeptide, which exerts immunosuppressive activity against activated T lymphocytes in contact dermatitis PMID: 24933319
44. Shp2 signaling in POMC neurons contributes to the long-term blood pressure and antidiabetic actions of leptin and may play a modest role in normal regulation of body weight. PMID: 25339680
45. Data suggest an important role of SHP2 in the molecular etiology of breast tumor growth. PMID: 24858400
46. We found that compared to the normal colon tissues, SHP-2 significantly decreased in mice colon tumor tissues. PMID: 24439672
47. we performed lineage tracing to show that exostoses and enchondromas in mice likely contain mixtures of wild-type and SHP2-deficient chondrocytes. PMID: 24875294
48. these findings define a role for Shp2 in alveolar macrophages and reveal that Shp2 is required to inhibit the progression of M2-associated pulmonary fibrosis. PMID: 25127857
49. Results reveal a critical role for SHP-2 in regulating experimental autoimmune encephalomyelitis pathogenesis. PMID: 24372081
50. SHP2 is essential for spermatogonial stem cells to maintain fertility. PMID: 24123360

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KEGG: mmu:19247

STRING: 10090.ENSMUSP00000058757

UniGene: Mm.8681