Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase isozyme L1 (Uchl1)

1. UCH-L1 is required for regulated protein degradation in the kidney by controlling proteasome abundance. Altered proteasome abundance renders renal cells, particularly podocytes and endothelial cells, susceptible to injury. PMID: 28754552
2. High UCHL1 expression is associated with posterior longitudinal ligament ossification. PMID: 29782494
3. PKCgamma-mediated down-regulation of UCHL1 alleviates ischemic neuronal injuries by decreasing autophagy via ERK-mTOR pathway. PMID: 28726275
4. Post-transcriptional loss of UCHL1 following status epilepticus is deleterious to neuronal survival. PMID: 28397067
5. The UCHL1 may play a role in myogenesis by promoting myoblast proliferation and inhibiting differentiation. PMID: 28803986
6. our study provides novel insights into the mechanisms of UCH-L1-mediated neurobiological functions and suggests that ubiquitination is an important regulatory signal for TrkB PMID: 28500221
7. Effects of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs. PMID: 26781791
8. The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene-induced transformation of, germinal center B cells. PMID: 26702068
9. Pharmacological inhibition of UCHL1 exacerbates rather than ameliorates disease symptoms in a mouse model of SMA. Thus, pharmacological inhibition of UCHL1 is not a viable therapeutic target for SMA. PMID: 25041530
10. Parkin mediates K63-linked polyubiquitination of UCH-L1 in cooperation with the Ubc13/Uev1a E2 ubiquitin-conjugating enzyme complex and promotes UCH-L1 degradation by the autophagy-lysosome pathway. PMID: 25403879
11. defective UCHL1 function may be an early contributor to vulnerability of pancreatic beta-cells for protein misfolding and proteotoxicity, hallmark defects in islets of T2DM PMID: 24879150
12. UCH-L1 facilitates PDGF-BB-induced suppression of autophagic degradation of p21WAF1/Cip1 proteins in cardiac fibroblasts PMID: 24732420
13. It plays a role in the hypothalamic-pituitary-gonadal axis and in the reproduction. PMID: 24770650
14. UCHL1 upregulation in ACTN4-associated FSGS. PMID: 24662305
15. downregulated miR-181b induces neuroprotection against ischemic injury through negatively regulating HSPA5 and UCHL1 protein levels PMID: 23900885
16. The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. PMID: 24090154
17. Activation of the NF-kappaB signaling pathway could be the major pathogenic mechanism to up-regulate UCH-L1 in podocyte injury. PMID: 23567262
18. in AD, Abeta may down-regulate UCH-L1 in the AD brain, which in turn impairs BDNF/TrkB-mediated retrograde signaling, compromising synaptic plasticity and neuronal survival. PMID: 23599427
19. UCH-L1 physically interacts with CDK1, CDK4, and CDK5, enhancing their kinase activity. PMID: 23543736
20. UCH-L1 impairs mTORC1 activity toward S6 kinase and 4EBP1. PMID: 23297343
21. Antisense Uchl1 increases UCHL1 protein synthesis at a post-transcriptional level, hereby identifying a new functional class of lncRNAs PMID: 23064229
22. Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression. PMID: 22342763
23. New insights into the role of UCHL1 in the mechanism of polyspermy block in mouse ova. PMID: 22223688
24. Data suggest that UCHL1 has functional roles (i.e., involved in insulin secretion, in ubiquitination, and as brake on cell proliferation) and anti-apoptotic role in pancreatic beta cells under endoplasmic reticulum stress caused by palmitic acid. PMID: 22038515
25. However, gad mice showed an increased activity during subjective day and a decreased number of orexin A-immunoreactive neurons in the LH compared with the wild type (WT). PMID: 20363052
26. Data suggest that the activity of oocyte UCHL-1 and -3 contributes to oocyte maturation by regulating the oocyte cortex and meiotic spindle. PMID: 21751213
27. subfertile Uchl1(gad-/-) mutant mice showed an intriguing pattern of switched UCH localization, with UCHL3 replacing UCHL1 in the oocyte cortex PMID: 21678411
28. Ubiquitin carboxyterminal hydrolase isozyme L1 showed higher levels in animals with good contextual fear conditioning extinction performance. PMID: 21770032
29. PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development PMID: 21678139
30. analysis of a possible mechanistic link between UCH-L1 modification by cyclopentenone prostaglandins and the etiology of neurodegeneration PMID: 20231490
31. found that, in the absence of UCH-L1, synaptic transmission at the neuromuscular junctions (NMJs) is markedly impaired. PMID: 20080621
32. PGP9.5-positive neural elements began to appear in the periodontal ligament of the hetrerozygote and wild type mice at day 7 following transection of the inferior alveolar nerve. PMID: 12846558
33. These data suggest that UCH L1, with avidity and affinity for ubiquitin, insures ubiquitin stability within neurons. PMID: 12913066
34. UCH-L1 may act during mitotic proliferation of spermatogonial stem cells PMID: 15084487
35. Results describe the gene expression pattern of the brain of 3-month-old Uch-l1-deficient gracile axonal dystrophy (gad) mice by microarray analysis. PMID: 15207921
36. UCHL1, and UCHL1-dependent apoptosis, are required for normal spermatogenesis and sperm quality control. PMID: 15744022
37. UchL1 is expressed in the suprachiasmatic nucleus PMID: 15889617
38. Results show that a component of the neuronal ubiquitin/proteasomal pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required for normal synaptic and cognitive function. PMID: 16923396
39. These results may identify UCH-L1 as a candidate for a sperm-oocyte interactive binding or fusion protein on the plasma membrane that functions during the block to polyspermy in mouse oocytes. PMID: 17071595
40. UCH-L1 is widely expressed in neurons in all brain regions analyzed, including dopamine neurons of the midbrain. In the periphery, UCH-L1 expression remains restricted to neurons in all organs examined. PMID: 17599367
41. These results provide evidences of UCH-L1/ubiquitination signaling to the testis IR injury in vivo. PMID: 18070598
42. We propose that UCH-L1-mediated maintenance of the temporal integrity and persistence of CREB phosphorylation underlies these impairments. PMID: 18279321
43. S18Y variant of UCH-L1 confers a novel antioxidant function in certain Parkinson's disease populations. PMID: 18411255
44. UCH-L1 regulates bone mineralization during osteogenesis. PMID: 18628613
45. Results suggest that Uch-L1 and Usp14 may differentially affect the ubiquitin proteasome system and synaptic activity by regulating different pools of ubiquitin in the cell. PMID: 18771733
46. Studies suggest sln and uchl1 genes as novel targets of AT deficiency and may offer molecular correlates of well documented descriptions of neuromuscular dysfunctions in AT-deficient rodents. PMID: 19204867

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KEGG: mmu:22223

STRING: 10090.ENSMUSP00000031131

UniGene: Mm.29807