Recombinant Mouse Upstream stimulatory factor 1 (Usf1)

1. Mice lacking Usf1 displayed increased BAT-facilitated, diet-induced thermogenesis with up-regulation of mitochondrial respiratory chain complexes, as well as increased BAT activity even at thermoneutrality and after BAT sympathectomy PMID: 26819196
2. USF1 exclusively bound to the CACGTG E-box motifs in the brain cortex neuron proximal promoter regions. Importantly, functional annotation of the USF1-binding targets revealed an enrichment of genes related to lysosomal functions. PMID: 26756308
3. Propose that USF1 is an important modulator of molecular and behavioral circadian rhythms in mammals via DNA-binding of the CLOCK:BMAL1 complex. PMID: 23580255
4. USF1 but not USF2 supports OPN expression in LRP6-VKO vascular smooth muscle lineage, and immunoprecipitation confirmed increased USF1 association with OPN chromatin. PMID: 26034040
5. Pdx1, USF1 and USF2 co-ordinately regulate Alx3 gene expression in pancreatic beta-cells. PMID: 25040025
6. USF1-centered regulatory networks were further confirmed by ChIP assays. PMID: 24686121
7. AGTRAP expression is regulated by USF1 and USF2 PMID: 23653383
8. USF1 transactivates GATA5 expression by binding to the E-box in its promoter PMID: 22625849
9. Data suggest that both USF1 and USF2 are essential for angiotensinogen (AGT) transcriptional regulation, and distinct sex-specific and tissue-specific mechanisms are involved in the activities of these transcription factors. PMID: 22547438
10. using a mouse model we show that the loss of USF-1 compromises DNA repair, which suggests that USF-1 plays an important role in maintaining genomic stability. PMID: 22291606
11. USF-1 binds the 5'PDbeta2 repressor element (E-box) in developing double-negative thymocytes. PMID: 22287717
12. critical transcription factor regulating diabetic kidney disease and plays a critical role in albuminuria, mesangial matrix accumulation, and TGF-beta1 and renin stimulation in diabetic kidney disease PMID: 21543418
13. USF regulates osteopontin gene transcription aortic vascular smooth muscle cells, entrained to changes in cellular glucose metabolism PMID: 12200434
14. USF binding to the E-box at -893/-888 serves to trans-repress basal expression and IL-1beta induction of the iNOS promoter. PMID: 12225970
15. USF1, along with ikaros-2, regulates delta opioid receptor expression in mouse T lymphocytes PMID: 12431989
16. Data show that USF1/-2 and CREB transcription factors binding to the cyclooxygenase-2 promoter induced H. pylori-dependent cox-2 transcription. PMID: 14531897
17. UV-induced expression of POMC and MC1R is dependent on the p-38-activated upstream stimulating factor-1 PMID: 15358786
18. Usf1, Runx1, and c-Myb play important roles as Edelta-dependent regulators of Ddelta2 accessibility in vivo PMID: 15778374
19. USF1 is stimulated by modest increases in glucose concentration in murine mesangial cells and binds to the murine TGF-beta1 promoter. PMID: 15983197
20. USF-1 is the major E-box-binding transcription factor regulating the Prnd promoter. PMID: 16297464
21. USF1 and USF2 bind the Fshr promoter and revealed differences between Sertoli and granulosa cells in compensatory responses to USF loss and the USF dimeric composition required for Fshr transcription PMID: 18566134
22. Data show that retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes. PMID: 18625721
23. In this study they asked whether the interactions between USF1/USF2 and E-Box and Nrf1 and GC-Box in the brain of mouse are influenced by postnatal age and what link it has with reported age-related decrease in the expression of Fmr-1 gene. PMID: 18782566
24. USF1 functionally and differentially regulates AGT expression via the -20 polymorphism and that the differential expression exhibited by -20 can be accounted for by differential association with USF1. PMID: 18802024
25. USF-1 specificity is directed via p38-mediated phosphorylation-dependent acetylation PMID: 19389701
26. USF regulates globin gene expression indirectly by enhancing the expression of erythroid transcription factors and directly by mediating the recruitment of transcription complexes to the globin gene locus. PMID: 19704006

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KEGG: mmu:22278

STRING: 10090.ENSMUSP00000125729

UniGene: Mm.8