Recombinant Mouse Uracil-DNA glycosylase (Ung)

1. Pms2/Mlh1 and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases. PMID: 28283534
2. UNG deficiency reduces B cell clonal expansion in the germinal center in mice and blocks the proliferation of tumor B cells expressing AID. PMID: 27697833
3. UNG might be involved in Tet-mediated DNA demethylation. PMID: 26620559
4. Study showed elevated levels of homocysteine via dietary folic acid deficiency and chronic hypoperfusion negatively affect learning in Ung deficient mice, while increasing GFAP immunoreactivity within the dentate gyrus of the hippocampus PMID: 25655513
5. Ung and Pms2 may exert a mutual backup function for the DNA incision that promotes synthesis by Poleta, each with a distinct strand bias. PMID: 24710273
6. Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase. PMID: 24591630
7. Our results uncover a specific need for UNG in class-switch recombination for timely and efficient acute Ab responses in vivo PMID: 23667108
8. Compared with WT mice, UNG deficiency caused elevated frequency of C:G mutations, suggesting that UNG-mediated U excision led to error-free as well as error-prone repair. PMID: 22960197
9. we show that AID binds cooperatively with UNG and the mismatch repair proteins Msh2-Msh6 to Ig Smu and Sgamma3 regions PMID: 21804017
10. analysis of species specific differences between mouse and humans in regulation of SMUG1 and UNG2 PMID: 21454529
11. The frequency of the D-1 mitochondrial (mt)DNA deletion in mtDNA is significantly increased in Ung-deficient mice, hence folate deficiency may contribute to neurodegeneration via mtDNA damage. PMID: 21281628
12. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in mice deficient in this enzyme. PMID: 12401169
13. Results provide compelling evidence that uracil-DNA glycosylase is of major importance for tissue repair after brain ischemia. PMID: 15199406
14. results indicate UNG is involved in the repair step of immunoglobulin class switch recombination (CSR) yet by an unknown mechanism; dispensability of U removal in the DNA cleavage step of CSR requires reconsideration of the model of DNA deamination by AID PMID: 15326357
15. Data show that protein synthesis but not uracil DNA glycosylase is required for the DNA cleavage step of immunoglobulin somatic hypermutation. PMID: 15684068
16. Ung-proteins, directly or indirectly, have important functions in the immune system, not only in the process of antibody maturation, but also for production and functions of immunologically important cell types PMID: 16174566
17. uracil-excision repair in oocytes is likely to be mediated by Udg2v2, or alternatively that Udg2v2 is involved in a process related to oocyte-specific maturation by virtue of its cyclin-like domains PMID: 16697536
18. Inactivating Ung alone reduced mutations from A and T, suggesting that, depending on the DNA sequence, varying proportions of A,T mutations arise by error-prone long-patch base excision repair PMID: 17015724
19. AID and Ung generate staggered double-strand DNA breaks (DSBs) not only by cleaving intact double-strand DNA, but also by processing blunt DSB ends. PMID: 18760480
20. The concerted action of Msh2 and UNG in stimulating A . T mutations also may have implications for mutagenesis at sites of spontaneous cytidine deamination. PMID: 19596785
21. Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation. PMID: 19901081

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KEGG: mmu:22256

STRING: 10090.ENSMUSP00000031587

UniGene: Mm.1393