Recombinant Mouse Vesicular glutamate transporter 1 (Slc17a7), partial

1. SH3 fusion protein pull downs using ITSN1SH3 A reveal diurnally varying binding of VGLUT1 with slightly reduced VGLUT1/dynamin ratios at the beginning of the light (ZT 0) or the dark (ZT 12) period. Phosphorylation increases binding of VGLUT1 but not of dynamin to EnphSH3. In contrast binding of dynamin to ITSN1SH3 A decreases under phosphorylating conditions with no changes in VGLUT1 binding. PMID: 29199069
2. Study shows by live-cell imaging with pH- and chloride-sensitive fluorescent probes in cultured hippocampal neurons of wild-type and VGLUT1-deficient mice that in synaptic vesicles VGLUT functions as a glutamate/proton exchanger associated with a channel-like chloride conductance. PMID: 29273736
3. early VGLUT1-specific parallel fiber synaptic input deficits and dysregulated cerebellar circuit as potential mediators of cerebellar dysfunction in frataxin knock-in/knockout mice. PMID: 29259026
4. Mice heterozygous for the vesicular glutamate transporter 1 (VGLUT1+/-) were used. Firstly, mRNA expression of the different members of the HDAC superfamily in the prefrontal cortex (PFC) of VGLUT1+/- mice and WT littermates were studied by RT-PCR. PMID: 28778545
5. These findings suggest that nitrosylation of VAChT and VGLUT1 may be associated with dysfunctional acetylcholinergic and glutamatergic neurotransmission in Alzheimer's disease. PMID: 27911305
6. Study revealed susceptibility of glutamatergic nerve terminals to Abeta induced toxicity and underlined the importance of VGLUT1 in the progression of Alzheimer's disease, as the decrease of this protein levels could increase the susceptibility to subsequent deleterious inputs by exacerbating Abeta induced neuroinflammation and synaptic plasticity disruption. PMID: 27258819
7. triple KO of Slc17a7, Slc17a6, and Slc17a8 diminished IIIS, which was rescued by exogenously introduced wild-type Slc17a7 or Slc17a6 genes PMID: 29091932
8. The observed changes in gene and protein expression of vesicular transporter 2, regional architecture, and morphology of mouse auditory forebrain may relate to-and to some extent enable-the emergence of mature sound-evoked activity patterns. PMID: 26159773
9. In CA1 pyramidal neurons, a slow excitatory postsynaptic current is absent in the VGLUT1 knockout mouse. PMID: 27567940
10. Data show that activation of nucleotide receptor P2Y4 (P2Y4) in the differentiating embryonic stem cells (ESCs) resulted in an increased proportion of neurons expressing vesicular glutamate transporter (vGluT). PMID: 26972684
11. Results suggest that activation of JNK in Alzheimer's disease (AD) inhibits insulin signaling which could lead to a decreased expression of VGLUT1, therefore contributing to the glutamatergic deficit in AD PMID: 26836159
12. Distribution of VGLUT1 and VGLUT2 in the CN, previously described for guinea pig, was replicated in mouse and showed similar changes in VGLUT1 and 2 distributions after unilateral cochlear insult PMID: 26705736
13. Here, we show that VGluT1(+/-) mice acquired the initial visual discrimination at the same rate as controls. However, they failed to suppress responses to the previously rewarded stimulus following reversal of reward contingencies. PMID: 26113146
14. conclude that VGLUTs contain two anion binding sites and one cation binding site, allowing the transporter to adjust to the changing ionic conditions during vesicle filling without being dependent on other transporters or channels. PMID: 25433636
15. our genetic analysis provides new in vivo evidence that VGluT1(+) glutamatergic signaling, mediated by the astroglial mGluR5 receptor, regulates the functional maturation of cortical astroglia during development. PMID: 25122895
16. Targeting of VGLUT-1 in the hippocampus leads to cognitive deficits in a knocked-down adult mouse model. PMID: 24037344
17. VGLUT1 enhances the tonicity of excitatory synaptic vesicles and stabilises SVs at presynaptic terminals. PMID: 23581566
18. This study demonstrates a key role for VGLUT1 in long-loop glutamatergic feedback control of 5-HT function. PMID: 23168115
19. These data indicate that VGluT1, but not VGluT2, plays a role in the neural processes underlying inhibitory learning PMID: 23396167
20. This study demonistrated that Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex after Antidepressant Drugs treatment in mice. PMID: 21945287
21. This study indicated that VGLUT1 may play an important role in some abnormalities associated with schizophrenia, particularly cognitive deficits PMID: 22197296
22. Here we studied VGLUTs type 1 and 2 (VGLUT(1) and VGLUT(2) , respectively) in neurons innervating the mouse colorectum. PMID: 21800314
23. This study provide a detailed analysis of synaptic vesicle sharing in vitro, and show that network homeostasis leads to dynamic scaling of synaptic VGLUT1 levels. PMID: 22031900
24. Data demonstrate that protein expression of VGLUT1 decreases age-dependently in senescence-accelerated mouse/prone 8 mice and increases in a learning- and memory-dependent manner in KM mice. PMID: 21295146
25. In an animal model of depression, chronic mild stress induces a transient decrease of VGLUT1 in brain. PMID: 20550627
26. This study suggested that a functional role of VGLUT1 in forms of hippocampal synaptic plasticity that are involved in the adaptation and modification of acquired spatial maps to external stimuli and changes in the environment. PMID: 19574394
27. VGLUT2, but not VGLUT1, plays a role in neuropathy-induced allodynia and hypersensitivity, and might be a therapeutic target to prevent and/or treat neuropathic pain PMID: 19171494
28. developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity; the loss of VGLUT1 reduced the reserve pool of synaptic vesicles [vglut1] PMID: 15118123
29. Data suggest that vesicular glutamate transporter 1 (VGluT1) plays a transient developmental role in some glutamatergic systems that mainly use VGluT2 in adulthood. PMID: 16217795
30. reduced amount of VGLUT1 per vesicle is probably achieved by means of selective sorting controlled by clock genes PMID: 16595674
31. FGF2 deficiency leads to decreased expression of presynaptic markers of integrity for glutamatergic fibers in the striatum, namely the membrane excitatory amino acid transporter 3 (EAAT3) and the vesicular glutamate transporter 1 (VGLUT1 PMID: 17161387
32. We found differences in the time course of developmental expression, with VGLUT1 peaking around P14, while VGLUT2 increased gradually until adulthood. PMID: 17289331
33. VGLUT1-ir is therefore present in extrinsic and intrinsic innervation of the mouse esophagus, but the significant differences from the rat indicate species variations concerning the distribution of VGLUTs in the peripheral nervous system. PMID: 17508221
34. about 65% of the total number of dorsal root ganglia neuron profiles expressed VGLUT2 PMID: 17577523
35. VGLUT1 is essential for transmitting visual signals from photoreceptors to second- and third-order neurons but is not necessary for intrinsic visual functions. PMID: 17611277
36. Cajal-Retzius cells and subplate neurons are glutamatergic;these two cells express VGLUT1 and VGLUT2, respectively, as the transport system of glutamate in events orchestrated by these cells during cortical development. PMID: 17651422
37. These results suggest that thalamocortical axon terminals contained not only VGLUT2 but also VGLUT1, especially at P7-10. PMID: 18028110
38. Blunted pre-synaptic glutamate response may contribute to memory deficit in middle-aged APdE9 mice. PMID: 18042177
39. VGluT1 in the VP is only found at corticothalamic synapses. By contrast, the two VGluT isoforms are co-localized in thalamocortical axon terminals targeting layer IV, but not in those targeting layer I. PMID: 18181146
40. VGLUT1 is sorted diurnally to the plasma membrane to modulate glutamate transmission during a day/night cycle, whereas VGAT expression is not oscillating but is increased in the presence of a light/dark cycle. PMID: 19103593
41. VGLUT1, and not ClC-3 as proposed previously, represents the major Cl(-) permeation pathway in synaptic vesicles PMID: 19169251
42. VGLUT1+/- mice showed increased neuronal synthesis of glutamate; decreased cortical and hippocampal GABA, VGLUT1, and excitatory amino acid transporter 1 (EAAT1) as well as helplessness and anhedonia. PMID: 19409534

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KEGG: mmu:72961

STRING: 10090.ENSMUSP00000082489

UniGene: Mm.255631