Product Details

Purity

>85% (SDS-PAGE)

Target Names

Zfp36l2

Uniprot No.

P23949

Alternative Names

Zfp36l2; Brf2; Tis11d; mRNA decay activator protein ZFP36L2; Butyrate response factor 2; TPA-induced sequence 11d; Zinc finger protein 36; C3H1 type-like 2; ZFP36-like 2

Species

Mus musculus (Mouse)

Expression Region

1-484

Target Protein Sequence

MSTTLLSPFY DIDFLCKTEK SLANLNLNNM LDKKAVGTPV AAAPSSSFTP GFLRRHSASN LHALAHPVPS PGSCSPKFPG APNGGGSSCG PAGGGGLASY GQLKEPSGGS GTALVTKESK FRDRSFSENG ERSQHLLHLQ QQQKGGSGSQ INSTRYKTEL CRPFEESGTC KYGEKCQFAH GFHELRSLTR HPKYKTELCR TFHTIGFCPY GPRCHFIHNA DERRPAPSGG GGASGDLRAF GARDALHLGF AREPRPKLHH SLSFSGFPSG HHQPPGGLES PLLLDSPTSR TPPPPSSSAS SCSSSASSCS SASAASTPSG APTCCATAAA AALLYGPGGA EDLLSPGAPC ASCSSSGANN AFAFGPELSS LITPLAIQTH NFAAAAAAAY YRNQQQGLTG PAPPPAQPPA APAPPSPPFG FQLPRRLSES PVFDAPPSPP DSLSDRDSYL SGSLSSGSLS GSESPSLDPG RRLPIFSRLS ISDD

Protein Length

Full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner. Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Gene References into Functions

Loss of ZFP36L2 is associated with female infertility. PMID: 29408237
The Zfp36l2 therefore act as posttranscriptional safeguards against chromosomal instability and replication stress by integrating pre-TCR and IL-7 signaling with DNA damage and cell cycle control. PMID: 27566829
Study tested for the first time a role of ZFP36L2 in the decay of LHR mRNA, when transcription was inhibited; results of our cell-based assay support the conclusion that LHR mRNA expression is controlled post-transcriptionally by ZFP36L2. PMID: 28455422
In mature peripheral neurons, ZFP36L2 mediates post-transcriptional mechanisms by promoting axonal integrity. PMID: 25505318
lack of the physiological down regulation of luteinizing hormone receptor mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest PMID: 24830504
ZFP36L2 therefore functions as part of a molecular switch promoting BFU-E self-renewal and a subsequent increase in the total numbers of colony-forming unit-erythroid (CFU-E) progenitors and erythroid cells that are generated PMID: 23748442
ZFP36L2 has a critical role in lymphocyte development and may function as a tumor suppressor. PMID: 20622884
model of disruption of the earliest stages of embryogenesis, implicating Zfp36l2, a probable mRNA-binding and destabilizing protein, in the physiological control of female fertility at the level of early embryonic development PMID: 15342461
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis PMID: 19633199

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Subcellular Location

Nucleus. Cytoplasm.

Tissue Specificity

Expressed in preadipocytes and adipocytes (at protein level). Expressed at highest level in lymphoid tissues such as thymus, spleen, lung, uterus, ovary, small and large intestine, mammary gland, fat and bone marrow. Expressed at intermediate level in kid

Database Links

KEGG: mmu:12193

STRING: 10090.ENSMUSP00000050820

UniGene: Mm.259321

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Recombinant Mouse Zinc finger protein 36, C3H1 type-like 2 (Zfp36l2)

Product Details

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Target Background

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