Recombinant Nuclear migration and anchoring protein unc-84 (unc-84), partial

Involved in nuclear migration and anchoring in hypodermal precursor cells. Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Its role in nuclear migration may be in association with lamin, lmn-1. Regulates nuclear migrations in one-cell embryos, controlling the posterior migration of the male pronucleus following fertilization. Not required for centrosome attachment to the nucleus. Plays a role in the maintenance of the nuclear envelope architecture in body wall muscle cells. May be involved in DNA damage repair through an association with zyg-12. Potentially has roles in homologous recombination, double strand break repair and meiotic recombination. Specifically, may in part inhibit non-homologous end joining repair, most likely through recruiting fan-1 to the nucleoplasm, to facilitate the repair of DNA cross-links.