Recombinant Pig Apolipoprotein E(APOE)

Code CSB-YP001936PI
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Source Yeast
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Code CSB-EP001936PI
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Source E.coli
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Code CSB-EP001936PI-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001936PI
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Source Baculovirus
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Code CSB-MP001936PI
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names APOE
Uniprot No. P18650
Alternative Names APOEApolipoprotein E; Apo-E
Species Sus scrofa (Pig)
Expression Region 19-317
Target Protein Sequence ED EPGPPPEVHV WWEESKWQGS QPWEQALGRF WDYLRWVQSL SDQVQEELLS TKVTQELTEL IEESMKEVKA YREELEAQLG PVTQETQARL SKELQAAQAR VGADMEDVRN RLVLYRSEVH NMLGQTTEEL RSRLASHLRN VRKRLVRDTE DLQKRLAVYQ AGLREGAERS VSALRERLGP LVEQGRLRAA TLSTRAGQPL RERAEAWGQK LRGRLEEMGS RTRDRLDEMR DELEEVRTKV EEQGSQLRLQ AEAFQARLKG WFEPLVEDMR RQWAGLVERM QSAVSISSST SAPSDNQ
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
Gene References into Functions
  1. These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant PMID: 21549015
Subcellular Location Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.
Protein Families Apolipoprotein A1/A4/E family
Database Links

KEGG: ssc:397576

STRING: 9823.ENSSSCP00000003343

UniGene: Ssc.1342

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Address
7505 Fannin St. Ste 610-312, Houston, TX 77054, USA
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