Product Details

Purity

>85% (SDS-PAGE)

Target Names

FUT1

Uniprot No.

Q29043

Alternative Names

FUT1Galactoside 2-alpha-L-fucosyltransferase 1; EC 2.4.1.344; Alpha(1,2)FT 1; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1

Species

Sus scrofa (Pig)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis. Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.

Gene References into Functions

FUT1 expression levels and low FUT2 expression levels in the intestines of Sutai pigs affected FUT1 and FUT2 enzymes, the synthesis of type 2 H and type 1 H antigens, and E. coli F18 adhesion. Moreover, low FUT2 expression levels conferred resistance to E. coli F18. PMID: 26985939
Polymorphism of FUT1 and MUC4 associated with resistance to colibacteriosis was determined. PMID: 25318177
The 5'-flanking region of the FUT1 gene (-1150 to +50 bp) exhibited promoter activity and the -1150-bp to -849-bp region showed negative regulation of the gene. PMID: 24336113
Studied the beneficial effects of alpha (1,2)-fucosyltransferase (FUT1) M307 (A) on piglet survival on commercial farms. Piglet survival for individuals with the AA genotype was almost two-fold greater than for GG individuals. PMID: 23777352
The results indicated that Sutai pigs with the AA genotype in M307 of FUT1 gene have relatively strong general disease resistance ability in piglets. PMID: 21769474
The mutation at M307 in the FUT1 gene determines susceptibility of small intestinal epithelium to E. coli F18 adhesion in Sutai piglets. PMID: 21691705
FUT1 mutations might play a role in pig infection by multi-pathogens, and the AA may be a favourable genotype for increasing the resistance to disease. PMID: 21695432
Beneficial genotype of swine FUT1 gene governing resistance to E. coli F18 is associated with important economic traits PMID: 21869481
transgenic male pigs were produced that possess an alpha alpha-1,3-galactosyltransferase knockout allele and express a randomly inserted human alpha 1,2-fucosylosyltransferase transgene PMID: 12672664
Genetic variability is assocated with reproductive traits. PMID: 16130473
Results showed that the genetic polymorphisms of the FUT1 locus were only detected in the 3 exotic pig breeds and indicated that FUT 1 gene and the type of breeds significantly affected total number born. PMID: 17284424
Results indicated that Chinese native pig breeds lack the genetic background, FUT1 genetic polymorphisms, on the resistance to ETEC F18 bacteria. PMID: 17855256
results showed that genetic polymorphisms of the FUT1 locus were only detected in western pig breeds & the Chinese Taihu, Huai & Lingao breeds; results indicated that Chinese native pig breeds lack genetic factors providing resistance to ETEC F18 bacteria PMID: 19134079

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Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Protein Families

Glycosyltransferase 11 family

Database Links

KEGG: ssc:397138

STRING: 9823.ENSSSCP00000003400

UniGene: Ssc.242

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Recombinant Pig Galactoside 2-alpha-L-fucosyltransferase 1 (FUT1), partial

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