Recombinant Plasmodium falciparum Gametocyte surface protein P230 (PFS230), partial

The recombinant Plasmodium falciparum (isolate 3D7) PFS230 was expressed with the amino acid range of 2980-3116. The expected molecular weight for the PFS230 protein is calculated to be 15.9 kDa. This protein is generated in a e.coli-based system. The PFS230 coding gene included the Tag-Free, which simplifies the detection and purification processes of the recombinant PFS230 protein in following stages of expression and purification.

The Plasmodium falciparum Gametocyte surface protein P230 (PFS230) is a crucial protein associated with the sexual stage of the malaria parasite's life cycle. Expressed on the surface of male and female gametocytes, PFS230 plays a vital role in the development and transmission of the parasite between the human host and the mosquito vector. PFS230 is involved in the formation of male and female gametes and subsequent fertilization within the mosquito midgut. Understanding the function of PFS230 is essential for developing interventions to disrupt the transmission of malaria, as targeting proteins involved in the sexual stages of the parasite's life cycle could potentially prevent its spread in the population.