Recombinant Probable beta-arrestin (arr-1)

Code CSB-YP344345CXY
MSDS
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Source Yeast
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Code CSB-EP344345CXY
MSDS
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Source E.coli
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Code CSB-EP344345CXY-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP344345CXY
MSDS
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Source Baculovirus
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Code CSB-MP344345CXY
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
arr-1
Uniprot No.
Alternative Names
arr-1; F53H8.2Beta-arrestin arr-1
Species
Caenorhabditis elegans
Expression Region
1-435
Target Protein Sequence
MVDEDKKSGT RVFKKTSPNG KITTYLGKRD FIDRGDYVDL IDGMVLIDEE YIKDNRKVTA HLLAAFRYGR EDLDVLGLTF RKDLISETFQ VYPQTDKSIS RPLSRLQERL KRKLGANAFP FWFEVAPKSA SSVTLQPAPG DTGKPCGVDY ELKTFVAVTD GSSGEKPKKS ALSNTVRLAI RKLTYAPFES RPQPMVDVSK YFMMSSGLLH MEVSLDKEMY YHGESISVNV HIQNNSNKTV KKLKIYIIQV ADICLFTTAS YSCEVARIES NEGFPVGPGG TLSKVFAVCP LLSNNKDKRG LALDGQLKHE DTNLASSTIL DSKTSKESLG IVVQYRVKVR AVLGPLNGEL FAELPFTLTH SKPPESPERT DRGLPSIEAT NGSEPVDIDL IQLHEELEPR YDDDLIFEDF ARMRLHGNDS EDQPSPSANL PPSLL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying.
Gene References into Functions
  1. We find that VANG-1 promotes Wnt signaling by facilitating Frizzled endocytosis and genetically acts in a common pathway with arr-1/beta-arrestin, whose mutation results in defective PLM branching and F-actin patterns similar to those in the Wnt, mig-1 or vang-1 mutants. On the other hand, the UNC-6/Netrin pathway intersects orthogonally with Wnt-PCP signaling to guide PLM branch growth along the dorsal-ventral axis. PMID: 28384160
  2. ARR-1 functions to regulate chemosensory signaling, enabling organisms to adapt to a variety of environmental cues, and provide an in vivo link between arrestin, receptor endocytosis, and temporal recovery from adaptation PMID: 15878875
Subcellular Location
Perikaryon. Cell projection, dendrite.
Protein Families
Arrestin family
Tissue Specificity
Expressed in head neurons, nerve ring and ventral nerve cord (at protein level). Expressed in the nervous system including the nerve ring and the ventral and dorsal nerve cords. Highly expressed in amphid chemosensory neurons AWA, AWB, AWC, ADL and ASH, a
Database Links

KEGG: cel:CELE_F53H8.2

STRING: 6239.F53H8.2

UniGene: Cel.6957

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