Recombinant Rat Axin-1(Axin1) ,partial

Code CSB-YP526666RA
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Source Yeast
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Code CSB-EP526666RA
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Source E.coli
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Code CSB-EP526666RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP526666RA
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Source Baculovirus
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Code CSB-MP526666RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Axin1
Uniprot No. O70239
Alternative Names Axin1; Axin; Axin-1; Axis inhibition protein 1; rAxin
Species Rattus norvegicus (Rat)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (By similarity). Also facilitates the phosphorylation of APC by GSK3B (By similarity). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (By similarity). Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity).
Gene References into Functions
  1. Data suggest TGFB2 (the most abundant growth factor in human milk) binding to Tgfb2r elicits robust/rapid response in small intestinal mucosal cells leading to stimulation of Egr1 transport to nucleus and cell differentiation; more than 15 Wnt signaling pathway genes have Egr1 binding sites/response elements; Egr1 binds to Axin1 promoter and functionally activates gene expression. (Egr1 = early growth response 1 protein) PMID: 27697743
  2. A novel function of Axin as an important regulator of ATRA-activated p53 expression. PMID: 23588680
  3. Axin protein was expressed in rat heart and increased significantly in left ventricles during norepinephrine-induced cardiac remodeling. PMID: 12817302
  4. We also found that cyclin A/CDK2 phosphorylates Axin, thereby enhancing its association with beta-catenin. PMID: 15063782
  5. We identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated with S-SCAM from rat brain PMID: 15228590
  6. The DIX domain of rat axin, which is important for its homooligomerization and interactions with other regulators in the Wnt pathway, has been purified and crystallized. PMID: 17554179
  7. Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway. PMID: 19513548

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Subcellular Location Cytoplasm, Nucleus, Cell membrane, Membrane
Tissue Specificity Highly expressed in testis, thymus and lung. Less expression in cerebrum, cerebellum, heart, kidney, skeletal muscle, spleen and liver.
Database Links

KEGG: rno:79257

STRING: 10116.ENSRNOP00000027705

UniGene: Rn.31781

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