Name: Recombinant Rat Cathepsin L1(Ctsl1)
Brand: CUSABIO
SKU: 006193RA

Product Details

Purity	>85% (SDS-PAGE)
Target Names	Ctsl
Uniprot No.	P07154
Alternative Names	Ctsl; Ctsl1Cathepsin L1; EC 3.4.22.15; Cathepsin L; Cyclic protein 2; CP-2; Major excreted protein; MEP) [Cleaved into: Procathepsin L; Cathepsin L1 heavy chain; Cathepsin L1 light chain]
Species	Rattus norvegicus (Rat)
Expression Region	18-334
Target Protein Sequence	TPK FDQTFNAQWH QWKSTHRRLY GTNEEEWRRA VWEKNMRMIQ LHNGEYSNGK HGFTMEMNAF GDMTNEEFRQ IVNGYRHQKH KKGRLFQEPL MLQIPKTVDW REKGCVTPVK NQGQCGSCWA FSASGCLEGQ MFLKTGKLIS LSEQNLVDCS HDQGNQGCNG GLMDFAFQYI KENGGLDSEE SYPYEAKDGS CKYRAEYAVA NDTGFVDIPQ QEKALMKAVA TVGPISVAMD ASHPSLQFYS SGIYYEPNCS SKDLDHGVLV VGYGYEGTDS NKDKYWLVKN SWGKEWGMDG YIKIAKDRNN HCGLATAASY PIVN
Protein Length	Full Length of Mature Protein
Tag Info	The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form	Lyophilized powder
Buffer before Lyophilization	Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet	Please contact us to get it.

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Target Data

Function	Important for the overall degradation of proteins in lysosomes. Procathepsin L is required for maximal stimulation of steroidogenesis by TIMP1.
Gene References into Functions	the activation of cathepsin L contributes to the irreversible depolarization produced by oxygen and glucose deprivation PMID: 27818353 Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model. PMID: 25558848 Inhibition of the activation of cathepsin L contributes to neuroprotection against cerebral ischemia. PMID: 24616078 Changes in olfaction were less consistent and widespread in the hippocampus, but were again sex specific for three genes: cathepsin-L (CtsL), matrix metalloproteinase-14 (MMP-14) and MMP-16. PMID: 23103411 With aging, the level of cathepsin L delined at 18 month but rose at 24 month in brain. PMID: 21374014 double transgenic rats (human renin and angiotensinogen genes) were used to investigate sex differences influencing renal function and gene expression. Cathepsin L was differentially expressed between the sexes and associated with degree of renal injury. PMID: 21357272 confirmed 6-hydroxydopamine induced nuclear translocation of cathepsin L in rat substantia nigral neurons as well PMID: 21134415 study found, in differentiated PC12 cells, lysosomal membrane permeabilization is an early event in palmitic acid-induced lipotoxicity preceeding mitochondrial membrane permeabilization & apoptosis; cathepsin L is an important contributor in this process PMID: 20043885 shows evolution in placental expression PMID: 12054558 the GC-box is a critical regulatory element for the cathepsin L promoter in mature Sertoli cells PMID: 12606333 data document that three Sp1/specificity protein 3 binding regions and a functional cyclic amp regulatory element constitute an important transcriptional regulatory complex for expression of the cathepsin L gene in rat granulosa cells PMID: 14563703 The induction of puromycin aminonucleoside nephrosis involves podocyte migration conducted by a coordinated interplay between the cysteine protease cathepsin L and alpha(3) integrin PMID: 15197181 endothelial cell-associated cathepsins B and L are not involved in the invasive growth of capillaries from existing blood vessels and the presence of collagen is necessary for MMP2 expression in endothelial cells PMID: 15255544 The co-localization of PAP/TRAP and the cysteine protease cathepsin L could suggest a role for cathepsin L in the in vivo proteolytic processing of PAP/TRAP. PMID: 15761664 Results show Cathepsin L plays a critical role in the lysosomal degradation of L-lactate dehydrogenase. PMID: 16960372 Our data strongly suggests that the decrease in heat shock protein levels and the significant reduction of serum albumin leakage into the brain following acute treatment with CP-1 is indicative of less secondary ischemic damage. PMID: 18060871 Study indicates that CTSL improves cardiac function and inhibits cardiac hypertrophy, inflammation, and fibrosis through blocking Akt/GSK3beta signaling. PMID: 19096818 Upstream repressors and activators as well as cis-acting elements near the transcription start site control stage-specific Ctsl transcription by Sertoli cells. PMID: 19458314 Show More Hide All
Subcellular Location	Lysosome, SUBCELLULAR LOCATION: Procathepsin L: Secreted
Protein Families	Peptidase C1 family
Tissue Specificity	Both mature cathepsin L1 and procathepsin L are found in the upper epidermis. The lower epidermis predominantly contains procathepsin L. In seminiferous tubules expression is greater at stages VI-VII than at stages IX-XII.
Database Links	KEGG: rno:25697 STRING: 10116.ENSRNOP00000025462 UniGene: Rn.1294

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Check Code：

Code	CSB-YP006193RA
Size	Pls inquire
Source	Yeast
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Code	CSB-EP006193RA
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Source	E.coli
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Code	CSB-EP006193RA-B
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP006193RA
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP006193RA
Size	Pls inquire
Source	Mammalian cell
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Recombinant Rat Cathepsin L1(Ctsl1)

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