Recombinant Rat Dynamin-1-like protein (Dnm1l)

1. knockdown of LRP6 inhibited the cell viability by activation of Drp1 in glucose deprived-cardiomyocytes. PMID: 29864925
2. In aortas of CKD rats and hippurate-treated rats, we observed an increase in Drp1 protein levels and mitochondrial fission. Inhibition of Drp1 improved endothelial function in both rat models. These results indicate that hippurate, by itself, can cause endothelial dysfunction. Increased mitochondrial fission plays an active role in hippurate-induced endothelial dysfunction via an increase in mitoROS PMID: 29573704
3. RhoA/ROCK pathways are involved in the phosphorylation and mitochondrial translocation of Drp1. PMID: 29336470
4. Authors demonstrate that YQFM ameliorates ischemic stroke-induced neuronal apoptosis through inhibiting mitochondrial dysfunction and PKCdelta/Drp1-mediated excessive mitochondrial fission. PMID: 29435096
5. miR-21-5p/203a-3p promote ox-LDL-induced endothelial senescence through down-regulation of Drp1 in a direct or indirect way. PMID: 28347692
6. Right ventricular ischemia occurs in pulmonary arterial hypertension and causes Drp1-Fis1-mediated fission leading to diastolic dysfunction. PMID: 28265681
7. Drp1-dependent mitochondrial fission changes in the dorsal vagal complex regulate insulin action. PMID: 28273447
8. Report a novel non-canonical function of the fission protein, DRP1 in maintaining or positively stimulating mitochondrial respiration, bioenergetics and ROS signalling in adult cardiomyocyte, which is likely independent of morphological changes. PMID: 27794519
9. The hypoxia-induced DRP1 expression depends on ROS generation, especially mitochondrial ROS (mROS). Moreover, the levels of ROS and mROS evoked by hypoxia were regulated by DRP1. PMID: 27010815
10. Drp-1 inhibition blocked BPA-mediated Drp-1 translocation, leading to decreased apoptosis of Neural Stem Cell. PMID: 27252377
11. Neurons overexpressing wild-type Drp1 promoted mitochondrial and nuclear fragmentation; however, neurons overexpressing dominant-negative Drp1(K38A) or cotreated with melatonin exhibited significantly reduced MPP(+) -induced mitochondrial fragmentation and neuron death. PMID: 27159033
12. Melatonin's protective effects were attributed to its roles in preventing cytosolic calcium ([Ca(2+) ]i ) overload, which blocked the recruitment of Drp1 from the cytoplasm to the mitochondria. PMID: 26732476
13. Inhibition of Drp1 prevents mitochondrial fission and reduces mechanical allodynia induced by perineural HIV-1 gp120. PMID: 26418124
14. Results show that Drp1 regulates proliferation and migration of vascular smooth muscle cells as well as neointimal formation in an carotid artery balloon injury model. . PMID: 25399916
15. NAC was able to prevent the rotenone-induced changes in parkin and Drp1 levels in the both studied areas. NAC delayed the Parkinson's disease induction by rotenone and this effect might be related to its proved antioxidant effect. PMID: 25732239
16. findings indicated that PINK1 is an endogenous protective mediator vital for neuronal survival under ischemic insult through regulating Drp1 phosphorylation at Ser616 PMID: 25791474
17. Results showed that under hypoxic/ischemic stress a Drp1-dependent mitophagy was triggered which was involved in the removal of damaged mitochondria and cellular survival at the early stage of hypoxic/ischemic injury PMID: 25018043
18. Phosphorylation of Drp1 at serine 616 (S616) is mediated by cyclin-dependent kinase 5 (CDK5) in post-mitotic rat neurons. PMID: 25012575
19. Drp1 inhibition triggers cardioprotection by reducing mitochondrial metabolism during ischemia reperfusion injury. PMID: 24477044
20. Opa-1 and Drp-1 in manganese-induced apoptosis PMID: 24632637
21. nitrite-induced increased mitochondrial superoxide generation dependent on the phosphorylation of Drp1 PMID: 24081164
22. Phosphorylation of DRP1 S622 was confirmed in phenylephrine-treated neonatal cardiomyocytes in an in vitro model of pressure-overloaded cardiac hypertrophy . PMID: 23882026
23. PINK1 ameliorated ischemia induced cell death and energy disturbance including reduced ATP generation and collapse of mitochondrial membrane potential by attenuating mitochondrial function. PMID: 23772688
24. Constitutive Drp1 overexpression leads to a state of chronic, abortive mitochondrial hyperfission. PMID: 23764851
25. Altogether, our data suggested that mdivi-1 exerts neuroprotective effects against cell death of hippocampal neurons induced by seizures, and the underlying mechanism may be through inhibiting CytC release. PMID: 23628672
26. Pim-1 activity prevents Drp1 compartmentalization to the mitochondria and preserves reticular mitochondrial morphology in response to sI PMID: 23530233
27. Drp1 LXVP motif shapes mitochondria in neuronal and non-neuronal cells, and that CaN-mediated Drp1 dephosphorylation promotes neuronal death PMID: 23486469
28. Over-expression of DRP-1 led to aggravated INS-1-derived pancreatic beta cell apoptosis triggered by free fatty acids. PMID: 23166623
29. Gliclazide showed protective effect on DPN through modulating Drp-1-mediated oxidative stress and apoptosis. PMID: 22732450
30. the involvement of DRP1 in physiological regulation of brain glucose-induced insulin secretion and food intake inhibition PMID: 22229526
31. a model for regulation of Drp1-dependent mitochondrial fission PMID: 22334657
32. DRP-1-mediated mitotic fission is a cell-cycle checkpoint that can be therapeutically targeted in hyperproliferative disorders such as pulmonary arterial hypertension. PMID: 22511751
33. These studies provide support for a substantial role of mitochondrial fission in preclinical models of inflammatory and neuropathic pain. PMID: 21813700
34. dynamin-related protein 1 (DRP-1), plays an important role in ER stress-induced beta-cell apoptosis PMID: 21537829
35. phosphorylation of Drp1 on Ser-585 promotes mitochondrial fission in mitotic cells[Drp1] PMID: 17301055
36. Data indicate a role for DLP1 as a novel component of the apical sorting machinery at the trans-Golgi network. PMID: 20688057
37. The Drp1 is required for the release of endonuclease G from mitochondria. PMID: 20594982
38. MiR-30 family members inhibit mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PMID: 20062521
39. DLP1 also caused global morphological changes in mitochondrial outer membrane-like liposomes, but DLP1 did not stimulate BAX-permeabilizing function in the absence or presence of Bif-1. PMID: 19074440

Show More

Hide All

KEGG: rno:114114

STRING: 10116.ENSRNOP00000002478

UniGene: Rn.216851