Recombinant Rat Glucokinase (Gck)

1. The enhancing effect of INGAP-PP on glucose-induced insulin release could be partly ascribed to its effect on glucokinase activity and glucose metabolism and is mainly mediated by the PI3K/AKT pathway. PMID: 25906449
2. Arcuate nucleus glucokinase activation may represent a CNS mechanism that underlies the oft-described phenomena of the "sweet tooth" and carbohydrate craving. PMID: 25485685
3. F0 maternal BPA exposure during gestation and lactation can induce impaired glucose homeostasis in the F2 offspring through DNA methylation change in Gck. PMID: 24793715
4. Data indicate that iron facilitates diabetes-mediated elevation of oxidative/nitrative stress, simultaneously impairs liver glucokinase, and can be a link between enzymatic changes and hepatic dysfunction. PMID: 22884880
5. The inhibitory effect of Urotensin IIon insulin secretion is associated with a suppression of GCK expression, not regulation of PDX-1 expression. PMID: 20401447
6. Results indicate that Pax6 acts on the regulation of glucagon secretion at least through the transcriptional control of GCK, GPR40, and GIPR. PMID: 22778220
7. Precedence of hypoglycemia diminishes glucokinase responses to recurring hypoglycemia in basal A2 noradrenergic neurons. PMID: 21488089
8. Modulation of GK by a novel glucokinase activator (GKA) that may enable the design of new and improved GKAs. PMID: 22044397
9. Glucokinase is localized in the nucleus and cytoplasm of glial tanycytes; its expression increases during postnatal development of the hypothalamic region. PMID: 20531973
10. Data report that DNA hypermethylation is correlated with a decline in hepatic glucokinase (Gck) and L-type pyruvate kinase (LPK) expression in high-fat diet-induced obese rats as compared with the control diet group. PMID: 21239437
11. investigation of mechanisms in regulation of glucokinase expression in pancreatic islets: roles of biotin, signal transduction pathways (involving soluble guanylate cyclase or protein kinase G), and insulin (autocrine function) PMID: 19560332
12. Our findings indicate that both glucokinase and glucokinase regulatory proteins may be functionally active before birth and that they can act within a glucose sensor system involved in controlling food intake. PMID: 19807849
13. To identify the binding site of these phosphate esters, we took advantage of the homology of GKRP to the isomerase domain of GlmS (glucosamine-6-phosphate synthase) and created 12 different mutants of rat GKRP. PMID: 11756407
14. Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes. PMID: 11950391
15. results suggest that the IRS-1-PI 3-kinase pathway is essential for insulin-induced expression of SREBP-1c and glucokinase genes PMID: 12031952
16. the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons PMID: 12086933
17. Improved metabolic disorders of insulin receptor-deficient mice by transgenic overexpression of this enzyme in the liver. PMID: 12242462
18. Substrate-induced nuclear export and peripheral compartmentalization in liver correlates with glycogen deposition PMID: 12369705
19. glucokinase produces glucose-6-phosphate which has a role in activating hepatic glycogen synthase PMID: 12519761
20. Protein kinase B has a role in insulin-dependent induction of glucokinase mRNA in hepatocytes. PMID: 14505487
21. a modest hepatic overexpression of glucokinase is sufficient to alter expression of metabolic genes without changing the expression of SREBP-1c PMID: 14674713
22. programming may influence methylation patterns in glucokinase at a distance from the promoter, or in genes encoding factors that regulate basal glucokinase expression PMID: 14706571
23. PPAR-gamma can directly activate glucokinase expression in liver and may contribute to improving glucose homeostasis in type 2 diabetes. PMID: 14749268
24. Hypothalamic glucokinase may be important component of glucoprivic counterregulatory responses. PMID: 15111491
25. insulin-dependent hepatic glucokinase expression is regulated by SREBP-1c PMID: 15123649
26. Glucokinase(GK) translocation from nucleus to cytoplasm in lean but not in Zucker diabetic fatty(ZDF) rats. Unresponsiveness of hepatic glucose to rise in plasma glucose and insulin in prediabetic ZDF rats associated with impaired GK translocation. PMID: 15138155
27. These results indicate that glucose-stimulated insulin release is decreased by chronic exposure to tacrolimus due to reduced ATP production and glycolysis derived from reduced glucokinase activity. PMID: 15479952
28. Glucokinase (GK), a key enzyme for pancreatic (beta)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. PMID: 15707679
29. Overexpression of PFK2 potentiated glucokinase expression in hepatocytes transduced with an adenoviral vector-encoding glucokinase. PMID: 15983194
30. asparagine-leucine motifs of glucokinase located in the hinge region confer binding to glucokinase regulatory protein (GRP) PMID: 16186382
31. The role of glucokinase as a critical regulator of neuronal glucosensing in ventromedical hypothalamic neurons was studied using a glucokinase activator and RNA interference. PMID: 16443775
32. These results showed that increases in SREBP-1c were neither necessary nor sufficient for Glucokinase induction in hepatocytes, while at the same time they underscored the role of SREBP-1c as a key regulator of Fatty acid synthase. PMID: 16834571
33. A defect is reported in glucose-induced dissociation of Gck from the regulatory protein in Zucker diabetic fatty rats in the early stages of diabetes. PMID: 17204595
34. In weanlings maintained on an hig fat diet for the first, second, or third week of gestation, hyperglycemia, a reduction in beta-cell volume and glucokinase mRNA. PMID: 17414058
35. coordinate roles for glucokinase and PFK2 in the elevated hepatic glycolysis in fa/fa Zucker rats PMID: 17553851
36. Diurnal variation of glucokinase-mRNA in pancreas. PMID: 17712721
37. Increases in intracellular glucose and net energy yield may be correlated with elevated GK and SUR1 gene transcription, respectively, in local glucose sensing neurons. PMID: 17889836
38. Results describe the impact of estradiol on caudal fourth ventricular lactate infusion and hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat lateral and ventromedial hypothalamus. PMID: 18084728
39. mechanisms downstream of AMP-activated protein kinase activation, involving phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and GKRP are involved in the ATP-independent inhibition of glucose-induced glucokinase translocation PMID: 18199594
40. Ventromedial hypothalamic GK activity is an important regulator of the counterregulatory response to insulin-induced hypoglycemia. PMID: 18292346
41. the epigenetic modification of the hepatic Gck promoter may represent an important marker for diabetogenic potential during the ageing process. PMID: 18496667
42. gender-dimorphic dorsal vagal complex GCK gene responses occur after single and serial intermediate-acting insulin administration PMID: 18612599
43. analysis of activation and translocation of glucokinase in rat primary hepatocytes PMID: 18812575
44. Endogenous lipophilic molecules modulate hepatic Gck expression. PMID: 19173678
45. A mechanism for LXRalpha in controlling the gene expression of LGK that involves activation through SREBP-1c and PPARgamma and inhibition through SHP, is proposed. PMID: 19366697
46. Gestational high-fat programming impairs insulin release and reduces Gck immunoreactivity PMID: 19604517
47. A study using inhibitors of PI 3-kinase and a conditionally active form of protein kinase B (cAKT) suggests that insulin induces the GCK gene in hepatocytes via the PI3-kinase/PKB signaling pathway PMID: 11042116

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KEGG: rno:24385

STRING: 10116.ENSRNOP00000019625

UniGene: Rn.10447