Recombinant Rat Merlin(Nf2)

Product Type Recombinant Protein
Uniprot No. Q63648
Abbreviation Nf2
Species Rattus norvegicus (Rat)
Gene Names Nf2
Protein Names Recommended name: Merlin Alternative name(s): Moesin-ezrin-radixin-like protein Neurofibromin-2 Schwannomin
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
HGNC 7773
RGD 3169
MGI 97307
Function Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.
Subcellular Location Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, Cytoplasm, cytoskeleton, Nucleus
Database Links

KEGG: rno:25744

STRING: 10116.ENSRNOP00000010690

UniGene: Rn.46695

Pathway Hippo signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Rat Merlin(Nf2),Yeast
Code CSB-YP726923RA
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence IASRMSFSSL KRKQPKTFTV RIVTMDAEME FNCEMKWKGK DLFDLVCRTL GLRETWFFGL QYTIKDTVAW LKMDKKVLDH DVSKEEPVTF HFLAKFYPEN AEEELVQEIT QHLFFLQVKK QILDEKVYCP PEASVLLASY AVQAKYGDYD PSVHKRGFLA QEELLPKRVI NLYQMTPEMW EERITAWYAE HRGRARDEAE MEYLKIAQDL EMYGVNYFTI RNKKGTELLL GVDALGLHIY DPENRLTPKI SFPWNEIRNI SYSDKEFTIK PLDKKIDVFK FNSSKLRVNK LILQLCIGNH DLFMRRRKAD SLEVQQMKAQ AREEKARKQM ERQRLAREKQ MREEAERSRD EPERRVLHMK EEATMANEAL MRSEETADLL AEKAQITEEE AKLLAQKAAE AEQEMQRIKA TAIRTEEEKR LMEQKVLEAE VLALKMAEES ERRAKEADQL KQDLQEAREA ERRAKQKLLE IATKPTYPPM NPIPAPLPPD IPSFDIIGDS LSFDFKDTDM KRLSMEIEKE KVEYMEKSKH LQEQLNELKT EIEALKLKER ETALDILHSE HSDSGTSSKH NTIKKPQAQG RRPICI
Expression Region 1-586
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Rat Merlin(Nf2),E.coli
Code CSB-EP726923RA
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence IASRMSFSSL KRKQPKTFTV RIVTMDAEME FNCEMKWKGK DLFDLVCRTL GLRETWFFGL QYTIKDTVAW LKMDKKVLDH DVSKEEPVTF HFLAKFYPEN AEEELVQEIT QHLFFLQVKK QILDEKVYCP PEASVLLASY AVQAKYGDYD PSVHKRGFLA QEELLPKRVI NLYQMTPEMW EERITAWYAE HRGRARDEAE MEYLKIAQDL EMYGVNYFTI RNKKGTELLL GVDALGLHIY DPENRLTPKI SFPWNEIRNI SYSDKEFTIK PLDKKIDVFK FNSSKLRVNK LILQLCIGNH DLFMRRRKAD SLEVQQMKAQ AREEKARKQM ERQRLAREKQ MREEAERSRD EPERRVLHMK EEATMANEAL MRSEETADLL AEKAQITEEE AKLLAQKAAE AEQEMQRIKA TAIRTEEEKR LMEQKVLEAE VLALKMAEES ERRAKEADQL KQDLQEAREA ERRAKQKLLE IATKPTYPPM NPIPAPLPPD IPSFDIIGDS LSFDFKDTDM KRLSMEIEKE KVEYMEKSKH LQEQLNELKT EIEALKLKER ETALDILHSE HSDSGTSSKH NTIKKPQAQG RRPICI
Expression Region 1-586
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Merlin(Nf2),Baculovirus
Code CSB-BP726923RA
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence IASRMSFSSL KRKQPKTFTV RIVTMDAEME FNCEMKWKGK DLFDLVCRTL GLRETWFFGL QYTIKDTVAW LKMDKKVLDH DVSKEEPVTF HFLAKFYPEN AEEELVQEIT QHLFFLQVKK QILDEKVYCP PEASVLLASY AVQAKYGDYD PSVHKRGFLA QEELLPKRVI NLYQMTPEMW EERITAWYAE HRGRARDEAE MEYLKIAQDL EMYGVNYFTI RNKKGTELLL GVDALGLHIY DPENRLTPKI SFPWNEIRNI SYSDKEFTIK PLDKKIDVFK FNSSKLRVNK LILQLCIGNH DLFMRRRKAD SLEVQQMKAQ AREEKARKQM ERQRLAREKQ MREEAERSRD EPERRVLHMK EEATMANEAL MRSEETADLL AEKAQITEEE AKLLAQKAAE AEQEMQRIKA TAIRTEEEKR LMEQKVLEAE VLALKMAEES ERRAKEADQL KQDLQEAREA ERRAKQKLLE IATKPTYPPM NPIPAPLPPD IPSFDIIGDS LSFDFKDTDM KRLSMEIEKE KVEYMEKSKH LQEQLNELKT EIEALKLKER ETALDILHSE HSDSGTSSKH NTIKKPQAQG RRPICI
Expression Region 1-586
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Merlin(Nf2),Mammalian cell
Code CSB-MP726923RA
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence IASRMSFSSL KRKQPKTFTV RIVTMDAEME FNCEMKWKGK DLFDLVCRTL GLRETWFFGL QYTIKDTVAW LKMDKKVLDH DVSKEEPVTF HFLAKFYPEN AEEELVQEIT QHLFFLQVKK QILDEKVYCP PEASVLLASY AVQAKYGDYD PSVHKRGFLA QEELLPKRVI NLYQMTPEMW EERITAWYAE HRGRARDEAE MEYLKIAQDL EMYGVNYFTI RNKKGTELLL GVDALGLHIY DPENRLTPKI SFPWNEIRNI SYSDKEFTIK PLDKKIDVFK FNSSKLRVNK LILQLCIGNH DLFMRRRKAD SLEVQQMKAQ AREEKARKQM ERQRLAREKQ MREEAERSRD EPERRVLHMK EEATMANEAL MRSEETADLL AEKAQITEEE AKLLAQKAAE AEQEMQRIKA TAIRTEEEKR LMEQKVLEAE VLALKMAEES ERRAKEADQL KQDLQEAREA ERRAKQKLLE IATKPTYPPM NPIPAPLPPD IPSFDIIGDS LSFDFKDTDM KRLSMEIEKE KVEYMEKSKH LQEQLNELKT EIEALKLKER ETALDILHSE HSDSGTSSKH NTIKKPQAQG RRPICI
Expression Region 1-586
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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