Neurofibromatosis type 2 (NF2) stems from mutations in the NF2 gene on chromosome 22. This gene encodes the Merlin protein, functions as tumor suppressor properties. NF2 mutations can impair the Merlin protein's function, reducing its tumor-inhibiting capabilities and increasing susceptibility to nervous system tumors such as vestibular schwannoma and meningioma. NF2 exemplifies the connection between genetic mutations and the development of nervous system tumors, providing valuable insights for diagnosis, treatment, and genetic counseling.
Recombinant Human Merlin (NF2) (CSB-EP015741HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NF2 Antibody (CSB-PA015741LA01HU)
Validated Data
Western Blot
Positive WB detected in: HEK293 whole cell lysate, Jurkat whole cell lysate, MCF-7 whole cell lysate, NIH/3T3 whole cell lysate
All lanes: NF2 antibody at 2.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70, 73, 60, 65, 64, 31, 66, 20, 25 kDa
Observed band size: 70, 73 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA015741LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA015741LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following NF2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NF2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015741GA01HU | NF2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA149148 | Phospho-NF2 (Ser518) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA779103 | NF2 (Ab-518) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA249373 | NF2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA003420 | NF2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA020074 | Phospho-NF2 (S518) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA020075 | Phospho-NF2 (S10) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020077 | NF2 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA015741LA01HU | NF2 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA015741LB01HU | NF2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA015741LC01HU | NF2 Antibody, FITC conjugated | Human | |
CSB-PA015741LD01HU | NF2 Antibody, Biotin conjugated | Human | ELISA |
NF2 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015741ZA01MO | Nf2 Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
NF2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015741HU CSB-BP015741HU CSB-MP015741HU CSB-EP015741HU-B |
Recombinant Human Merlin (NF2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP015741HU | Recombinant Human Merlin (NF2) | E.coli |
NF2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP015741MO1 CSB-BP015741MO1 CSB-MP015741MO1 CSB-EP015741MO1-B |
Recombinant Mouse Merlin (Nf2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP015741MO1 | Recombinant Mouse Merlin (Nf2), partial | E.coli |
NF2 Proteins for Papio anubis (Olive baboon)
Code | Product Name | Source |
---|---|---|
CSB-YP015741ERI CSB-EP015741ERI CSB-BP015741ERI CSB-MP015741ERI CSB-EP015741ERI-B |
Recombinant Papio anubis Merlin (NF2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NF2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP726923RA CSB-EP726923RA CSB-BP726923RA CSB-MP726923RA CSB-EP726923RA-B |
Recombinant Rat Merlin (Nf2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |