Recombinant Rat Metabotropic glutamate receptor 5 (Grm5), partial

1. Subchronic administration of ketamine, a well-studied, non-competitive antagonist of NMDA receptors, caused cognitive deficits in rats as shown by testing novel object recognition (NOR); increased the mRNA and protein expression levels of mGluR5 receptors in regions CA1 and CA3 of the dorsal part of the hippocampus, both of which are strongly associated with the formation of visual memory. PMID: 28433499
2. Results suggest that PKCvarepsilon is required to generate Ca(2+) oscillations following mGluR5 activation, which support the regulation of astrocytic glutamate uptake. Reduced expression of astrocytic PKCvarepsilon could impair this neuroprotective process and participate in the progression of amyotrophic lateral sclerosis (ALS). PMID: 29266405
3. Study shows an increase in metabotropic glutamate receptor 5 expression in the trigeminal nucleus and spinal cord dorsal horn of rats, 7 days after chronic constriction injury of the infraorbital nerve or the sciatic nerve. PMID: 28533177
4. We concluded that mGluR5 could regulate neuronal polarity and axon outgrowth during the morphological differentiation of rat developing neurons, and the intracellular signaling pathway of Akt-NF-kappaB might be involved in the action of mGluR5 PMID: 28019025
5. Results showed that prolonged cocaine self-administration, through withdrawal, leads to a blunting of group I metabotropic glutamate receptor responses in the striatum. In addition, specifically in the accumbens, group I metabotropic glutamate receptor signaling to cAMP responsive-element binding protein shifts from an agonist-induced to an antagonist-induced cAMP responsive-element binding protein phosphorylation. PMID: 27744406
6. Data suggest that chemotherapy- (paclitaxel-)induced painful neuropathy is associated with increased presynaptic mGluR5 activity at spinal cord level; up-regulation of presynaptic mGluR5 activity appears to increase upstream signaling for PKC-mediated tonic activation of NMDARs in afferent spinal neurons. (PKC = protein kinase C; NMDARs = N-methyl-D-aspartate receptors) PMID: 29074619
7. High-frequency stimulation-induced synaptic potentiation in dorsal and ventral CA1 hippocampal synapses. The mGluR5 contributed to the post-tetanic potentiation more in the ventral hippocampus more than in the dorsal hippocampus. PMID: 27531836
8. These data suggest a causal relationship between individual differences in the changes in hippocampal mGluR5 expression induced by repetitive restraint stress and the accompanying changes in ensemble neural activity in the hippocampus. PMID: 29191654
9. Results suggest that mGluR5 activation is necessary for estradiol-mediated enhancement of responses to cocaine, but that direct mGluR5 activation is insufficient to mimic the female response to estradiol: estradiol acts via an mGluR5-dependent mechanism to enhance cocaine self-administration in ovariectomized female rats. PMID: 27822496
10. Significant differences in mGluR5 availability between the different circadian times were found in cortex, cingulate cortex, amygdala, caudate putamen and nucleus accumbens. PMID: 27357735
11. Cocaine self-administration and extinction/reinstatement model rats showed modality dependent and brain-region specific changes in mGlu5 receptors' localization and membrane specific binding. PMID: 27871824
12. The mGlu5 receptor is essential for synaptic encoding of spatial experience and memory. PMID: 27055771
13. A ligand binding mutation within the extracellular domain of mGluR5 impairs both surface expression and dimerization of mGluR5 in neurons. PMID: 27211252
14. Results suggest that antagonism of mGluR5 activity in the nucleus accumbens neither disrupts sexual behavior nor blocks the long-term effects of sexual experience and abstinence on sensitized amphetamine responses PMID: 26946431
15. plasmalemmal mGluR5 clusters in distinct areas, the size, and initial spatio-temporal level of occupancy of which dictated mGluR5 trafficking characteristics upon glutamate stimulation PMID: 27014856
16. activation in perirhinal cortex reduces relapse to methamphetamine seeking by restoring novelty salience PMID: 26365953
17. Results demonstrated that mGluR5 regulates neurogenesis in retinal progenitor cells through the MAPK and PI-3-K signaling pathways PMID: 26902516
18. explore whether D2Rs regulate metabotropic glutamate receptor 5 (mGluR5) in its tyrosine phosphorylation and whether the D2R-SFK pathway modulates trafficking of mGluR5 PMID: 26777117
19. These findings provide a novel link between mGluR5 and DNA damage in a model of Parkinson's disease, and reveal a potential mechanism by which mGluR5 mediates DNA damage in neurodegenerative diseases. PMID: 26454081
20. mGlu5 activity appears particularly important in fear extinction consolidation in P17 rats, compared to the older ages PMID: 25497704
21. enhanced expression of mGluR5 and potentiation of Ca(2+) signaling may represent pro-survival upregulation of Ca(2+)-dependent genomic processes PMID: 26318863
22. Intracellular mGlur5 plays a role in neuropathic pain. PMID: 26837579
23. Restoring endocannabinoid signaling allows mGluR5 activation to increase infralimbic output and inhibit pain behaviors. PMID: 26791214
24. This study demonstrated that the Male prenatal chronic mild stress rats expressed significantly lower mGluR5 levels in the hippocampus and prefrontal cortex. PMID: 26071959
25. The expression of mGluR5 is increased in the striatum of female rats in prenatally stressed offspring. PMID: 25894678
26. Results provide compelling evidence that mGluR5 regulation is altered in schizophrenia, likely contributing to the altered glutamatergic signaling that is associated with the disorder PMID: 25778620
27. mGluR5 antagonist MPEP prevents the onset of seizures and increased generation of NO in the cerebral cortex of GEP rats in response to acoustic stimulation. mGluR5 plays an important role in the pathogenetic mechanisms of audiogenic seizures. PMID: 26033576
28. Recycling of mGluR5 in spinal cord is involved in the regulation and development of neuropathic pain. PMID: 26538661
29. CaMKIIalpha selectively regulates mGluR1a and mGluR5a ERK1/2 signaling. PMID: 25885040
30. Results suggest that nerve demyelination results in the increases of metabotropic glutamate receptor subtype 5 (mGluR5) expression in injured primary afferents. PMID: 25739080
31. This study demonstrated that Glur5 expression in rat auditory midbrain neurons. PMID: 25627107
32. Results suggest that synergistic endocannabinoid mobilization in hippocampal CA1 neurons is greater in juveniles than in neonates, and that this may result from increases in the mGluR5-PLCbeta1 endocannabinoid pathway PMID: 25185819
33. data support that although extinction learning in a new context is unaffected by mGlu5 antagonism, extinction of the consolidated context is impaired; this suggests mGlu5 is intrinsically involved in enabling learning that once-relevant information is no longer valid PMID: 25160592
34. Blockade of mGluR5 in nucleus accumbens shell in rats specifically suppresses the relapse to heroin-seeking and anxiety-like behavior. PMID: 25399651
35. Data support that mGlu5 plays an important role in the enablement of the stability and longevity of the encoding of spatial representations by place cells PMID: 24910241
36. data suggest that metabotropic glutamate receptor 5 serves as a switch that alters signal-to-noise ratios during information encoding. in the CA3 region. PMID: 25810529
37. Activation of mGluR5 protects differentiated PC12 cells from NMDA-induced neuronal excitotoxicity by disrupting NMDAR-PSD-95 interaction. PMID: 24941251
38. Data show that it is possible to substantially change nociceptive responses of thalamic neurones by increasing or decreasing degree of mGlu1 receptor activation, nociceptive responses of thalamic neurones are dependent upon a cortico-thalamic projection PMID: 24373900
39. The temporal and spatial changes in mGluR5 availability suggest [11C]ABP688 PET imaging in epilepsy provide abnormal glutamatergic network during epileptogenesis. PMID: 24663806
40. Determining how mGluR5 dynamics are regulated in response to neuronal input enables a better understanding of neuron-astrocyte communication. PMID: 24510777
41. Norbin associates with actin rather than with PSD-95 in dendritic spines. PMID: 24670218
42. mGlu5 receptor modulates late-LTP in apical dendrites PMID: 23978512
43. Data indicate the need to avoid an ago-positive allosteric modulators (PAM) pharmacological profile in both the parent compound and its major metabolites in the quest to develop allosteric ligands for metabotropic glutamate receptor 5 (mGlu5)activation. PMID: 24050755
44. Generation of a comparative model of the transmembrane-spanning region of mGluR5 served as a tool to predict and interpret the impact of mutations in this region. PMID: 23444015
45. Impaired mGluR5 activity in infralimbic prefrontal cortex synapses modulates fear expression leading to anxiety disorders. PMID: 23616528
46. Treatment with a positive allosteric modulator of mGlu5 increases the delay rats are able to withstand in the delayed alternation version of the T-maze. Results emphasize the role of mGlu5 receptors in spatial learning tasks. PMID: 23137441
47. Only painful facet joint distraction produces a significant increase in neuronal mGluR5 over time, and this increase is significantly elevated at day 7. PMID: 22578356
48. Data suggest that activation of mGluR5 during single-spike pairing at CA3-CA1 hippocampal synapses gates NMDA (N-methyl-D-aspartate) receptor-dependent long-term potentiation; this effect is observed in hippocampus of older rats. PMID: 22652057
49. An inflammatory environment triggers an opposite gene expression regulation of two predominant subtypes, mGluR5 and mGlur3, found in glial cells. PMID: 22245498
50. data support that chronic hyperammonemia reduces glutamate release and activation of the glutamate-NO-cGMP pathway by activation of mGluR5 PMID: 22521775

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KEGG: rno:24418

STRING: 10116.ENSRNOP00000022059

UniGene: Rn.29972