Recombinant Rat Metalloproteinase inhibitor 2 (Timp2)

1. Dynamics of distribution of capillaries with MMP2 and TIMP2 expressed in rat brain during development of experimental hypertension has been reported. PMID: 29308554
2. During the processes of conjunctival filtering bleb and scar formation in rats, the changes in MMP-2 and TIMP-2 levels in the filtering area, together with a corresponding proliferation of fibroblasts and the accumulation of collagen fibres, resulted in scarring of filtering blebs. PMID: 29075637
3. These findings suggested that artesunate attenuates alveolitis and pulmonary fibrosis by regulating expression of collagen-IV, TIMP-1 and 2, as well as MMP-2 and -9, to reduce ECM accumulation. PMID: 27323108
4. Data suggest that amlodipine and Atorvastatin could improve ventricular remodeling in SHR rats through intervention with the imbalance of MMP-2/TIMP-2 and MMP-9/TIMP-1 system. PMID: 27322513
5. decreased in diabetic skin PMID: 26047379
6. Lung tissue from burn animals showed increased matrix metalloproteinase activity, decreased levels of TIMP-2, and no difference in levels of active MMP-9 in burn vs. control groups. PMID: 26601648
7. MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression were significantly reduced in the lateral prostatic lobe of the ethanol drinking animals. PMID: 26258010
8. The present study suggests that EPO can exert a cardioprotective effect on DOX-induced cardiotoxicity which may be associated with improving MMP-2/TIMP-2 imbalance. PMID: 24685074
9. Enhancement of TIMP-2 expression may be a potential therapeutic target for neuroinflammatory disorders. PMID: 24970341
10. Bone marrow mononuclear cell transplantation significantly increased MMP-9 and MMP-13, and decreased TIMP expression. PMID: 23886643
11. the expression of TIMP-2 increased only in the neutrophils, endotheliocytes, and fibroblasts, remaining to be equal over all stages. PMID: 23383440
12. Membrane type 1 MMP, MMP2, and TIMP2 were present in testis during gonocyte migration and transformation into spermatogenic stem cells. PMID: 22974613
13. Inulicin inhibits hyperplasia of neointima by modulating the balance of MMP-2 and TIMP-2. PMID: 21141515
14. Data show that MMPs 2 and 9 and their inhibitors, TIMPs 1 and 2, are upregulated in response to oxidative stress produced by HIV-1 gp120 in a rat model of HIV encephalopathy. PMID: 22092673
15. NDRG2 contributed to an increase in the ratio of matrix metalloproteinase 2 (MMP2) to tissue inhibitor of matrix metalloproteinase 2 PMID: 22110735
16. Trained spontaneously hypertensive rats showed higher metalloproteinase-2/tissue inhibitor metalloproteinase-2 (MMP-2/TIMP-2) ratio and lower levels of alpha-smooth muscle actin. PMID: 22045123
17. A dramatic increase of TIMP1 mRNA and a decrease of TIMP2 in DRG after sciatic nerve transection. PMID: 21782897
18. the present study showed for the first time the mode of TIMP-1 and -2 expression and activity in a rat liver fibrosis model. PMID: 20226641
19. After transfection with FRNK, MMP-2 was up-regulated and TIMP-2 was down-regulated in hepatic stellate cells. PMID: 18983773
20. The TIMP-2 gene mediated by adenovirus can renew the balance of degradation of the extracellular matrix caused by elastase and inhibit the formation of an abdominal aortic aneurysm. PMID: 20103929
21. Addition of follicle stimulating hormone to Sertoli cells increased the TIMP-2 mRNA level three-fold, implicating a role in spermatogenesis. PMID: 11928819
22. Data show that matrix metalloproteinase-2 and TIMP-2 are likely involved in the FSH-induced changes in Sertoli cells. PMID: 12039062
23. tissue inhibitor of metalloproteinase-2 mRNA was observed surrounding the developing corpus luteum and was present in granulosa-lutein cells, with high levels near the center of the corpus luteum PMID: 12444073
24. results suggest that the migration and invasion of cardiac fibroblasts is furin-dependent and that the active species of MT1-MMP and MMP-2 may be involved in both events PMID: 12970340
25. In the process of hepatic fibrosis, fibroblasts and myofibroblasts are the major cells that express TIMPs and the more serious the hepatic fibrosis is in the injured liver, the higher the level of TIMP-1 and TIMP-2 gene expression. PMID: 14695775
26. Blood leukocytes and loss of flow are major factors in the activation of MMP-2, and cytokine-mediated differential regulation of TIMP-1 and TIMP-2 may contribute significantly to blood brain barrier failure. PMID: 16707552
27. MMP2 plays a role in the development of BC metastases. Furthermore, our results suggest that astrocyte factors and the ERK1/2 signaling pathway may be associated with BC brain metastasis development. PMID: 17505812
28. matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1 and osteopontin have roles in heart failure in DOCA-salt hypertensive rat PMID: 18415800
29. TIMP-2 is an osteoanabolic factor in vitro and in vivo PMID: 18558556
30. The induction of MMP-2, MMP-9, TIMP-1 and TIMP-2 mRNAs post-castration could be at least in part due to post-transcriptional stabilization. PMID: 18675881
31. investigated the involvement of matrix metalloproteinases (MMPs), tissue inhibitor (TIMP) and endothelin-1 (ET-1) in the renal damage in spontaneously hypertensive rats following nitric oxide deprivation. PMID: 18935914
32. over-expressed ZAK may contribute to the progression of myocardial remodeling by disrupting the balance in the MMP-2/9 and TIMP-1/2 expression level, respectively PMID: 19184368

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KEGG: rno:29543

STRING: 10116.ENSRNOP00000004290

UniGene: Rn.10161