Recombinant Rat Neurexin-1 (Nrxn1), partial

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

Nrxn1

Uniprot No.

Q63372

Alternative Names

Nrxn1; Neurexin-1; Neurexin I-alpha; Neurexin-1-alpha

Species

Rattus norvegicus (Rat)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.

Gene References into Functions

Results determined the crystal structures of the trimeric C1q-like domain of cerebellin-1, and the first complete ectodomain of GluD2. Cerebellin binds to the LNS6 domain of alpha- and beta-neurexin-1 through a high-affinity interaction that involves its highly flexible N-terminal domain. PMID: 27926833
study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complex. PMID: 27033232
Structural and functional analyses of the sixth site of neurexin alternative splicing PMID: 26335821
structure of Calsyntenin 3 and its interaction with neurexin 1alpha PMID: 25352602
The results showed that AChE clusters colocalized with neurexin assemblies in the neurites of hippocampal neurons. PMID: 24594013
Neurexin 1 can induce functional inhibitory synapse connections when presynaptic interneurons express a neurexin isoform that binds to neuroligin 1. PMID: 23426688
Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin. PMID: 22840401
Neurexin 1 binding to latrophilin-1 produces a stable intercellular adhesion complex. PMID: 22262843
Neurexin-1alpha is a component of the beta-cell secretory machinery and contributes to secretory granule docking, most likely through interactions with granuphilin. PMID: 22235116
Neurexin-1 is involved in the formation of the slit diaphragm of the glomerular podocytes in the kidney, and the maintenance of its function. PMID: 21048075
Neurexin1 was upregulated in both frontal cortex and caudate putamen in hypoxia rats. PMID: 20945070
the neurexin 1beta/neuroligin 1 complex has a role in synapse formation PMID: 15797875
Neurexin-1 beta is perhaps most important for GABA synapse formation or controlling the balance of GABA and glutamate synapses PMID: 16624946
The recognition properties of individual neuroligins toward beta-neurexin-1 (NX1beta), along with the influence of their splice inserts, were explored by surface plasmon resonance and affinity chromatography. PMID: 17042500
Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses. PMID: 17868325
beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding. PMID: 18334216
X ray structures reveal the mechanism by which neurexin 1beta isoforms acquire neuroligin splice isoform selectivity. PMID: 18334217
Data show beta-cell expression of the neurexin 1, and demonstrate that the neurexins are expressed outside the central nervous system and help confer an inhibitory synaptic-like phenotype onto the beta-cell surface. PMID: 18755801

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane.

Protein Families

Neurexin family

Tissue Specificity

Brain (neuronal synapse).

Database Links

KEGG: rno:60391

UniGene: Rn.54924

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Recombinant Rat Neurexin-1 (Nrxn1), partial

Product Details

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Target Background

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