Recombinant Rat Paired box protein Pax-6 (Pax6)

1. Results demonstrate that the miR-365-PAX6 system regulates the conversion of astrocytes into neurons in the ischemic brain. Both exogenous expression of PAX6 and administration of miR-365 antagomir are likely to promote brain repair by enhancing neurogenesis in adult mammalian brain following ischemic injury. PMID: 29451327
2. Four upregulated transcription factors Pax6, Tp73, Cebpd, and Spi1, appeared as potent regulators of chronic post-traumatic brain injury (TBI) gene expression. They regulate molecular networks contributing to post-injury secondary damage, including apoptosis and inflammation, strengthening the feasibility of therapeutically targeting these molecular networks even after the acute post-TBI period. PMID: 29482641
3. These results suggest that Pax6 immunoreactivity showed diverse patterns in the neurogenic zone after prenatal hypoxia and Pax6 has important effects on neurogenesis PMID: 29102934
4. analysis of the effect of Pax6 mutation on brain morphology and sex differences PMID: 27355350
5. High-fat diet feeding during pregnancy may induce insulin resistance in maternal rats by inhibiting pancreatic Pax6 and its target genes expression. PMID: 26191217
6. Up-regulation of Pax6 in neural progenitor cells plays an essential role in valproate-induced glutamatergic differentiation. PMID: 24030726
7. High glucose suppresses Pax6 expression in pancreatic beta-cells. PMID: 24953606
8. Pax6-transfected cells exhibited a similar growth curve (P>0.05), suggesting that the Pax6 5a has a similar effect on the proliferation of rMSCs as Pax6 PMID: 24952136
9. Our observations reveal intensive astroglial de-differentiation and proliferative response, reflected by dynamic Pax6 up-regulation PMID: 24114637
10. findings suggest that dual regulation of proneural genes mediated by Pax6 and Dmrt family members is crucial for cortical neurogenesis PMID: 23679989
11. Pax6 is essential for maintaining Neural stem/progenitor cells & determining their differentiation fates. PMID: 22944581
12. Results indicate that Pax6 acts on the regulation of glucagon secretion at least through the transcriptional control of GCK, GPR40, and GIPR. PMID: 22778220
13. The direct action of Pax6 on PC1/3, GK, Nkx6.1, GLP-1R, and GIPR gene promoters is elucidated through identification of functional binding sites in each promoter region. PMID: 22403172
14. Pax6 decreases the number of Neuron-Glia 2 progenitor cells and prevents oligodendrocytic lineage commitment, while repression of Olig2 results in an expanded astrocytic lineage. PMID: 22162276
15. provide evidence that Pax6 binds to the olig2 promoter and that an HEB sequence in the promoter is required for the Pax6 repression of olig2 transcription PMID: 21698109
16. Pax6 seems to be required for coordinating boundary-cell specification and reducing neurogenesis within the hindbrain boundary region PMID: 21501682
17. Results suggest Dlx2 and Pax6 may play a prominent role in directing neural precursor cell proliferation and neuroblast generation following striatal cell loss. PMID: 21397028
18. Pax6 has a role in the rat model of autism PMID: 21203536
19. at low concentrations of glucose, Pax6 is localized in the nucleus and prevents the activation of the insulin gene by occupying the PDX-1 binding site and by interacting with BETA2 PMID: 20943817
20. Results describe the expression of Pax6 and Sox2 in normal olfactory epithelium and during epithelial regeneration after methyl bromide lesion or olfactory bulbectomy. PMID: 20852734
21. Pax6 is critical for alpha cell function and differentiation through the transcriptional control of key genes involved in glucagon gene transcription, proglucagon processing, and alpha cell differentiation PMID: 20592023
22. Gene ontology analyses of the differentially expressed molecules demonstrated that Pax6 is involved in various signal transduction pathways where it regulates the expression of many receptors, signaling molecules, transporters and transcription factors. PMID: 20082710
23. Pax6 regulates specification of the ventral neurone subtypes by establishing the correct progenitor domains PMID: 11880342
24. brain-specific aldolase C gene could constitute a new target for the transcription factor Pax-6, which is implicated increasingly in neurogenesis PMID: 12370174
25. Pax-6 plays a role in the migration of medullary precerebellar neurons, although neurons generated in the lower rhombic lip can nevertheless migrate and settle to form the external cuneate nucleus in the absence of Pax-6. PMID: 12534968
26. Pax6's function in the control of cell proliferation and neuronal fate determination during embryogenesis is also operative in the adult hippocampus PMID: 16035109
27. Pax6 regulation of Optimedin in the eye and brain may directly affect multiple developmental processes, including cell migration and axon growth PMID: 16115881
28. An appropriate dosage of Pax6 is essential for production and maintenance of the GFAP+ early progenitor cells in the postnatal hippocampal neurogenesis PMID: 16164600
29. Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin-A5. PMID: 16510508
30. results demonstrate that fusion of the facial processes reduces the number of odontogenic placodes and is required to assemble all components at one site for rat upper incisor formation PMID: 16795023
31. These findings indicate differential requirements for pax6 gene dosage in displaying function and maintaining architecture of adult pancreatic islets. PMID: 17178107
32. Pax6 regulates the interkinetic nuclear migration by stabilizing the centrosome at the apical side. PMID: 17825043
33. PAX proteins have also been implicated in maintaining stem cells in a committed but undifferentiated state but a role for PAX proteins in putative pancreas stem cells is not known PMID: 17849422
34. Pax6 is a multifunctional player regulating proliferation and differentiation through the control of expression of different downstream molecules in a highly context-dependent manner [review] PMID: 18467663
35. Studied PAX6 homeodomain for PAX6 binding and function on G1 and G3 in rat glucagon gene promoter. Data indicate a PH0-like binding of PAX6 to glucagon promoter elements G1 and G3 where the HD binding site is abutted directly to the PD binding motif. PMID: 19217949

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KEGG: rno:25509

STRING: 10116.ENSRNOP00000006302

UniGene: Rn.89724