Recombinant Rat Pendrin (Slc26a4), partial

Code CSB-YP865637RA
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP865637RA
MSDS
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Source E.coli
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Code CSB-EP865637RA-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP865637RA
MSDS
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Source Baculovirus
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Code CSB-MP865637RA
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Slc26a4
Uniprot No.
Alternative Names
Slc26a4; Pds; Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4
Species
Rattus norvegicus (Rat)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Sodium-independent transporter of chloride and iodide.
Gene References into Functions
  1. These studies implicate the involvement of pendrin-facilitated chloride-bicarbonate exchange in the regulation of airway surface liquid volume and suggest the utility of pendrin inhibitors in inflammatory lung diseases. PMID: 26932931
  2. these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess. PMID: 26791486
  3. Pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release. PMID: 26173457
  4. Expression of slc26a4, slc26a6 and slc26a9 is increased in proximal tubule epithelial cells from spontaneously hypertensive rats compared with WKY control rats. PMID: 23933130
  5. Excessive mucus production, as implicated by significant overexpression of the pendrin coding gene, SLC26A4, was identified as a potential novel mechanism for silica-induced pulmonary toxicity. PMID: 22431001
  6. These data show that intracellular iodide rapidly upregulates SLC26A4 mRNA expression. PMID: 22178794
  7. its presence in both the apical plasma membrane and the apical intracellular vesicles of type B and non-A-non-B intercalated cells suggests that HCO secretion may be regulated by trafficking between the two membrane compartments PMID: 12217866
  8. metabolic acidosis decreases the activity of the apical Cl(-)/HCO(3)(-) exchanger in beta-ICs of the rat CCD by reducing the expression of pendrin. PMID: 12388388
  9. Metabolic acidosis and alkalosis with maintained water and sodium intake affected pendrin expression in kidney cortex collecting duct cells; regulation of pendrin expression may be clinically important in the correction of acid-base disturbances PMID: 12556366
  10. Pds(pendrin protein) expression is specifically regulated in response to changes in chloride balance in the rat kidney PMID: 15292050
  11. pendrin expression is regulated in acidotic rats with no changes in aldosterone & no external Cl load.Pendrin reduction may help redirect tubules to Cl excretion & HCO3 reabsorption, leading to increased plasma HCO3 & decreased Cl of respiratory acidosis. PMID: 17182533
  12. pendrin expression and localisation are regulated by insulin and influenced by a PKC-epsilon-dependent intracellular pathway. PMID: 18459119

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Subcellular Location
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families
SLC26A/SulP transporter (TC 2.A.53) family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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