Recombinant Rat Protein phosphatase 1 regulatory subunit 1B (Ppp1r1b)

1. Results indicate that the M4 muscarinic receptor plays a critical role in modulating phosphorylation of DARPP-32-Thr75 in striatal medium spiny neurons; suggest that M4 receptor activation acts antagonistically with dopamine D1-like receptors within the striatum, and indicate that M4 receptors may be a potential target for the treatment of Parkinson's disease and other relevant central nervous system disorders. PMID: 28257887
2. In a model of subarachnoid hemorrhage, rats with hydrocephalus had more severe basal ganglia injury with greater DARPP-32 depletion than rats without hydrocephalus. PMID: 26463938
3. we also demonstrated frequent co-overexpression and positive correlation of DARPP-32, SRp20 and CD44E expression levels in human gastric primary tumors. PMID: 26119931
4. Darpp32 interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system. PMID: 26639316
5. Study demonstrated that DARPP-32 was not altered in prefrontal cortex and hippocampus in sepsis PMID: 24978930
6. In cortical & striatal brain regions, 3 different neuronal populations either expressing SSTRs & DARPP-32 alone or displaying colocalization were identified. SSTR-positive neurons lacking DARPP-32 colocalization may be spared in excitotoxicity. PMID: 22116741
7. DARPP32 has a role in pluripotent stem cell differentiation toward medium-sized spiny neurons PMID: 23250204
8. This study demonistrated that Changes in nucleus accumbens and neostriatal c-Fos and DARPP-32 immunoreactivity during different stages of food-reinforced instrumental training PMID: 22462413
9. Fine-tuning of DARPP-32 levels leads to changes in the kinetics or sensitivity of MAPK/ERK signaling. PMID: 22301787
10. In the striatum of methamphetamine-sensitized rats, phosphothreonine-DARPP-32 immunoreactivities are increased, but DARPP-32 immunoreactivities are not significantly different. PMID: 11954050
11. acute stress resulted in the activation of DARPP-32 neurons, which were innervated by PACAP-ir neuronal structures in the extended amygdala PMID: 12409216
12. DARPP-32 phosphorylation was studied in morphine-sensitized rats at different times after morphine challenge which increased levels of phospho-Thr75 DARPP-32 and decreased phospho-Thr34 DARPP-32 levels with time in caudate-putamen and nuucleus accumbens PMID: 15287884
13. Based on the shape and spatial distribution of these cells, their staining by an anti-parvalbumin antibody, and their juxtaposition with processes containing tyrosine hydroxylase, that DARPP-32 is present in AII amacrine cells of rat retina. PMID: 15515184
14. Methamphetamine induced an increase in phosphorylation of DARPP-32/Thr75. PMID: 15536496
15. DARPP-32 is critical for the maintenance of thyroid differentiation by TSH and IGF-I, and loss of DARPP-32 expression may be a characteristic of thyroid cancer. PMID: 16020482
16. the deletion of KKIQF, a PP1-binding motif of DARPP-32, resulted in a remarkable reduction in its affinity with PP1. PMID: 16428298
17. This is the first report that DARPP-32 phosphorylation within the prefrontal cortex is associated with recognition as well as temporal order memory for objects. PMID: 16687181
18. In some cortical structures (prelimbic and cingulate cortices, the dentate gyrus) as well as in the central amygdala, RHA-I rats showed higher DARPP-32 mRNA expression than RLA-I rats PMID: 17008016
19. These data indicate that DARPP-32 participates in dopamine-mediated modifications of retinal function. PMID: 17552992
20. These data suggest that a tonic increase in mGluR5 transmission in cocaine-sensitized rats sustains both the increase in phospho-Thr75 DARPP-32 levels and the expression of behavioral sensitization. PMID: 17680995
21. although DARPP-32 impacts cortical inhibition through a previously demonstrated D2-dependent regulation of GABAergic currents in pyramidal cells, it is not involved in the direct D1-mediated regulation of fast-spiking interneurons PMID: 17693396
22. Collectively, these findings suggested that changes of the DARPP-32 phosphorylation state may be important for over-activation of the direct pathway. PMID: 17884291
23. chronic electroconvulsive stimulation increased transient expression of DARPP-32 in several time frames, in striatum and hippocampus PMID: 17919461
24. results showed that inhibitory avoidance (IA) induced changes on DARPP-32 expression in striatum and hippocampus. DARPP-32 expression changes corroborate with changes in expression and phosphorylation of CREB, NMDA, AMPA after IA PMID: 18415674
25. The nuclear accumulation of DARPP-32, a potent inhibitor of protein phosphatase-1, increases the phosphorylation of histone H3, an important component of nucleosomal response. PMID: 18496528
26. upon phosphorylation of Thr(34) in DARPP-32, which turns DARPP-32 into a potent inhibitor of PP1, neither local nor long-range structure of DARPP-32 is altered PMID: 18954090
27. Basal and cocaine-induced sex differences in the DARPP-32/PP-1 cascade may be responsible for the sexual dimorphism in acute cocaine-induced behavioral responses. PMID: 18985320
28. Methylphenidate induces changes in total DARPP-32 expression that are posology- and age-related in some rat brain areas, although further studies are needed to shed more light on the mechanisms behind these findings. PMID: 19041388
29. All five dopamine receptor subtypes and DARPP-32 were expressed in rat brain cortex and striatum. DARPP-32 positive neurons displayed comparative colocalization with dopamine receptor subtypes 1-5. PMID: 19465068
30. Within the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) cascade of enzymes that plays a central role in signal integration of dopaminoceptive neurons multiple catalytic and regulatory subunits change their mRNA expression levels PMID: 19474310
31. in the midbrain ventral tegmental area, progesterone's actions to facilitate sexual behavior of female rodents, involving D1 receptors, may require DARPP-32. PMID: 19782104

Show More

Hide All

KEGG: rno:360616

STRING: 10116.ENSRNOP00000034614

UniGene: Rn.70366