Recombinant Rat Scavenger receptor class B member 1(Scarb1),partial

Code CSB-YP020767RA
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Source Yeast
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Code CSB-EP020767RA
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Source E.coli
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Code CSB-EP020767RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP020767RA
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Source Baculovirus
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Code CSB-MP020767RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Scarb1
Uniprot No. P97943
Alternative Names Scarb1; Scavenger receptor class B member 1; SRB1; SR-BI
Species Rattus norvegicus (Rat)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Gene References into Functions
  1. Taken together, DEHP-disturbed HPT axis and induced 5alpha-Reductase 2 contribute to the reduction of serum testosterone level. The activated ERK pathway is required to modulate expressions of 5alpha-Reductase 2 and SRB1. PMID: 27155079
  2. The results suggest that NHERF1 and NHERF2 down-regulated SR-B1 at least in part via the ubiquitin/proteasome pathway. PMID: 28669731
  3. Model recombinant HDL (rHDL) particles formed in vitro with S1P incorporated into the particle initiated the internalization of S1PR1, whereas rHDL without supplemented S1P did not, suggesting that S1P transported in HDL can selectively activate S1PR1. PMID: 27881715
  4. Chronic vitamin A-enriched diet feeding decreased hypercholesterolaemia and normalized HDL-C levels, possibly by regulating pathways involved in HDL synthesis and degradation, independent of hepatic SR-B1 in this glucose-intolerant obese rat mode PMID: 27934803
  5. role for SIK1 in the positive regulation of selective HDL-CE transport function of SR-B1 and steroidogenesis PMID: 26567857
  6. SR-B1 may be involved in uterine function, follicular development as well as luteal function. PMID: 25817199
  7. data establish NHERF1 and NHERF2 as SR-BI protein binding partners that play a negative role in the regulation of SR-BI expression, selective CE transport, and steroidogenesis. PMID: 23482569
  8. ovarian granulosa cells retain the cholesterol homeostatic control machinery like nonsteroidogenic cells, although during active steroidogenesis, they utilize SR-BI to evade such feedback control PMID: 23197320
  9. Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps. PMID: 22767607
  10. Data show that niacin therapyreduced renal tissue lipids, CD36, ChREBP, LXR, ABCA-1, ABCG-1, and SR-B1 abundance and raised PPAR-alpha and L-FABP. PMID: 19878707
  11. subcellular localization of scavenger receptor class B type I (SR-BI) in the arterial walls of rats (SR-BI) PMID: 11882321
  12. SR-BI is a phagocytosis-inducing PS receptor of Sertoli cells. PMID: 12016218
  13. Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transport. PMID: 12493702
  14. basal and SR-BI-stimulated free cholesterol efflux to HDL and liposomes and SR-BI-mediated selective uptake of HDL cholesteryl ester are not affected by caveolin-1 expression PMID: 12562842
  15. the SR-BI pathway supplies the majority of the cholesterol required for androgen production in theca cells and a crucial role for SR-BI in HDL-mediated androgen production. PMID: 12746305
  16. concluded that the PTS1 domain of SR-BI is functional and can mediate peroxisomal interaction via Pex5p, in vitro PMID: 14652019
  17. SR-BI self-association represents an integral step in the selective cholesteryl ester uptake process PMID: 14657200
  18. SR-BI is highly expressed in different neuro-retinal and non-neuronal cells types on rat eye. PMID: 14694755
  19. results indicate that SR-BI functions on both the apical and basolateral plasma membranes of Sertoli cells, and that SR-BI expression in Sertoli cells changes during the spermatogenic cycle and is stimulated, at least in cultures, by FSH PMID: 15206959
  20. data indicate that stimulation of the cAMP-PKA-CREB pathway enhances rat SR-BIpr activity and substantiate the role of CREB as an intermediary in this process PMID: 16298471
  21. Results indicate that class B scavenger receptor type I (SR-BI) binds to phosphatidylserine, activating the mitogen-activated protein kinase pathway and leading to the induction of the engulfment of PS-exposing apoptotic cells by phagocytic cells. PMID: 16530182
  22. PPARalpha was able to induce the activity of the rat SR-BI promoter in conjunction with RXRalpha PMID: 16584836
  23. Results show that SR-BI, ATP-binding cassette A1 and G1 mRNA expression increased in response to dexamethasone while insulin treatment reduced the expression in primary rat hepatocytes. PMID: 17241464
  24. scavenger receptor class B, type I and the low-density lipoprotein receptor have roles in High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake PMID: 17905649
  25. SR-BI at the inner blood-retinal barrier is responsible for alpha-tocopherol uptake from the circulating blood and plays a key role in maintaining alpha-tocopherol in the neural retina. PMID: 18079677
  26. Resistin promotes foam cell formation via dysregulation of SR-A, CD36 and ABCA1. PMID: 19041881
  27. Phosphatidylserine-recognizing SR-BI activates associated GULP; activated GULP induces MAPK phosphorylation; activated MAPK increases GTP-bound Rac1; and activated Rac1 induces a rearrangement of the actin cytoskeleton. PMID: 19122200

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Subcellular Location Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein.
Protein Families CD36 family
Database Links

KEGG: rno:25073

STRING: 10116.ENSRNOP00000060874

UniGene: Rn.88169

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