Recombinant Rat Sigma non-opioid intracellular receptor 1 (Sigmar1), partial

1. These results led us to hypothesize the existence of functional D2-sigma1R complexes on the rat striatal DA and glutamate nerve terminals and functional D2-sigma1R-DA transporter complexes on the striatal DA terminals. PMID: 28923416
2. these results indicate that Sigmar1-dependent activation of IRE1alpha-XBP1s ER-stress response pathways are associated with inhibition of CHOP expression and suppression of cellular toxicity. PMID: 28667101
3. Study showed that sigma1 receptors play a role in regulation of both CA1 synaptic efficacy and neural plasticity-dependent rat spatial learning ability. Its regulatory role in activity-dependent CA1-LTP is locality- and age-dependent, whereas its role in spatial learning ability is age-dependent. PMID: 26860755
4. Study demonstrated that SKF10047 (SKF) of higher dosages (30-100 muM), suppress AMPAR-mediated responses of rat ON retinal ganglion cells via sigmaR1. SKF did not affect glutamate release from bipolar cells, suggesting that both the effects are a consequence of postsynaptic actions of SKF on retinal ganglion cells. PMID: 27373906
5. Sigma-1 receptor was also upregulated in vivo upon VP16-CREB expression in astrocytes. PMID: 27761593
6. acupoint catgut embedding exhibited antihyperalgesic effects via the inhibition of the Sig-1R that modulated p38 MAPK, but not ERK, expression in the complete Freund's adjuvant-induced inflammatory pain model in rats PMID: 28682953
7. Together these results support the hypothesis that sigma1R agonists promote dissociation of sigma1R multimers into monomers, which then interact with DAT to stabilize an outward-facing DAT conformation and enhance cocaine binding. PMID: 28495886
8. Study found: sigma-1 receptor is abundant in dorsal root ganglion (DRG) neuronal soma, but not in satellite cells; sigma-1 receptor is absent in processes of DRG neurons; in DRG neurons, S1R targets endoplasmic reticulum, nuclear envelope, and plasma membrane. PMID: 27339730
9. data demonstrate that miR-297 promotes cardiomyocyte hypertrophy by inhibiting the expression of Sig-1R and activation of ER stress signaling, which provides a novel interpretation for cardiac hypertrophy. PMID: 28286226
10. Study found that repeated treatment with oxaliplatin or paclitaxel causes neuropathy accompanied by the reduction of Sig-1Rs in the rat spinal cord PMID: 26234785
11. Sigma-1 receptor blockade reduces the propensity to both acquire alcohol drinking and to seek alcohol. Data suggest that Sig-1R antagonists may have therapeutic potential in multiple stages of alcohol addiction. PMID: 25848705
12. Cholinergic lesioning causes an increase of sigma-1 receptor expression in a small cortical area which may be neuroprotective. PMID: 25273321
13. SKF83959 promoted the binding of DHEA with sigma-1 receptors in rat hippocampal microglia. PMID: 26031312
14. Suggest that activation at the sigma-1 receptor chaperone may be involved in the action of some selective serotonin re-uptake inhibitors. PMID: 24508523
15. data show that sigma1R is present in both sensory neurons and satellite cells in rat DRGs. PMID: 24015960
16. sigma1R is downregulated following PO-induced endothelial injury in OVX rats. PMID: 23965801
17. Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats. PMID: 23732704
18. this study was designed to determine whether the role of sigma Receptors in cognitive function, anxiety, depression, and the regulation of stress responses extends to ethanol-seeking behavior PMID: 22878224
19. Sig-1Rs negatively regulate the activity of GalCer synthesis under physiological conditions by enhancing the degradation of CGalT. PMID: 23105111
20. sigma-1 receptor activation inhibits glutamate release from rat cortical nerve terminals. PMID: 22357973
21. sigmaR1 may be involved in the regulation of output signaling of ganglion cells by preferentially modulating NMDA receptor-mediated excitatory postsynaptic currents of these retinal neurons. PMID: 21555866
22. Acute withdrawal from chronic intermittent ethanol exposure triggered sigma-1 receptors that act to depress the efficacy of excitatory inputs in triggering action potentials during long term potentiation. PMID: 21314692
23. These data further confirmed that Sig-1Rs play critical roles in the central nervous system PMID: 21905129
24. Activation of sigma-receptors plays a key facilitatory role in the reinforcing effects of alcohol through a potential mechanism that contributes to binge-like and excessive drinking. PMID: 21346735
25. results suggest that sigma-1 receptors may amplify the D1 receptor agonist-induced PKA activation by sigma-1 receptors PMID: 20732358
26. sigmaR1 may have neuromodulatory and neuroprotective roles in the retina. PMID: 20223280
27. Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates hypertension-induced kidney hypertrophy in ovariectomized rats PMID: 20404054
28. Sig-1Rs as endogenous regulators of hippopcampal dendritic spine formation suggest a free radical-sensitive ER-mitochondrion-Rac1.GTP pathway in the regulation of dendritic spine formation in the hippocampus PMID: 20018732
29. Results suggest that sigma receptors serve as auxiliary subunits to voltage-gated K+ channels with distinct functional interactions, depending on the presence or absence of ligand. PMID: 11988171
30. Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. PMID: 12037190
31. Sigma-1 receptors play an important role in nerve growth factor-induced neurite sprouting in vitro. PMID: 12438547
32. Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system. Sigma(1)-receptor colocalized with specific markers of progenitor (A2B5) and mature oligodendrocytes (GalC, RIP). PMID: 12535781
33. The Double immunofluorescence studies showed that sigma(1)-receptor co-localized with S100 protein, a specific marker of Schwann cells, in both rat sciatic nerve Schwann cells and Schwann cells in cultures. PMID: 15064136
34. Sigma-1 receptors may play an important role in directing epidermal growth factor (EGF)signaling towards neuritogenesis, perhaps by shifting EGF receptors from the lipid raft into non-raft regions. PMID: 15170821
35. Sig-1Rs targeting GalCer-containing lipid microdomains are important for oligodendrocyte differentiation. PMID: 15466698
36. Sig-1R plays an important role in BDNF signaling leading to glutamate release as shown by antidepressant pretreatment PMID: 16522641
37. role of opioid receptor sigma 1 modulating sensitivity to morphine in the periaqueductal gray, the rostroventral medulla, and the locus coeruleus of the rat PMID: 17545312
38. Demonstrate that N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine protects liver against the deleterious effects of ischemia-reperfusion and suggest that sigma(1) receptors play an important role in the protective effect. PMID: 17964567
39. sigma-1 receptor activation can regulate calcium homeostasis and signaling in RGCs, likely by directly influencing the activity of L-type voltage-gated calcium channels. PMID: 18641291
40. sigma-1 receptor stimulation inhibits ASIC1a-mediated membrane currents and consequent intracellular Ca2+ accumulation. PMID: 18723775
41. The results collectively support an endogenous role for brain Sig-1Rs in the modulation of excessive ethanol intake and reinforcement. PMID: 18946467
42. N,N-dimethyltryptamine is an endogenous agonist for the sigma-1 receptor PMID: 19213917

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KEGG: rno:29336

STRING: 10116.ENSRNOP00000019795

UniGene: Rn.1129