Recombinant Rat Tyrosine-protein phosphatase non-receptor type 1 (Ptpn1)

1. These findings reveal a novel role for pancreatic PTP1B in cerulein- and arginine-induced acute pancreatitis. PMID: 27461362
2. deleterious role that the amygdalar PTP1B has on energy homeostasis in obesity states PMID: 28403933
3. The results suggest that neonatal MS experience may blunt the anorectic efficacy of leptin later in life, possibly in relation with increased expressions of PTP1B and/or pSTAT3 in the hypothalamus PMID: 28229972
4. overexpression of PTP1B can inhibit glucose-stimulated insulin secretion in INS-1 cells through negatively regulating insulin signaling. PMID: 26099503
5. PTP1B expression is up-regulated following spinal cord injury. PMID: 25894283
6. Study suggested that brain mitochondrial dysfunction following lipopolysaccharide-induced sepsis in rats is partly attributed to PTP1B and Src mediated decrease in mitochondrial protein tyrosine phosphorylation PMID: 25998537
7. After retinal detachment, weak immunolabeling of PTP1B was seen in the retinal pigment epithelial cells. PMID: 25999679
8. Overexpression of PTP1B by treatment with free fatty acids did not translate into negative modulation of insulin signaling in cells treated with unsaturated free fatty acids. PMID: 23481236
9. Complement-mediated glomerular injury is reduced by inhibition of protein-tyrosine phosphatase 1B. PMID: 25056348
10. An increased PTP1B expression in the hypothalamus underlies the development of leptin resistance during repeated exposure to Lipopolysaccharides. PMID: 25352433
11. Data indicate that protein tyrosine phosphatases SHP-1, SHP-2 and PTP1B overexpressed during the development of cerulein -induced acute pancreatitis can be modulated by extracellular signal-regulated kinases (ERK1/2) and c-Jun NH2-terminal kinase (JNK). PMID: 24225419
12. Contents released from injured epithelial cells can inactivate renal fibroblasts by dephosphorylation of EGFR through a mechanism involved in PTP1B activation. PMID: 23283996
13. role of PTP1B in structural plasticity within the hippocampus PMID: 22844492
14. Fe(2+)-generated O(2) mediates p21(ras) and TAK1 activation via PTP inhibition and Lys(63)-polyUb of TRAF6 in caveosomes for proinflammatory M1 activation in hepatic macrophages PMID: 22829592
15. PTP1b within the solitary tract nucleus may be a novel molecular mechanism for preservation of resting baroreflex function and provides further evidence for deleterious cardiovascular effects associated with PTP1b inhibition PMID: 22569287
16. The data suggest that TNFalpha acts on the hypothalamus to increase hypothalamic PTP1B expression and activity via the NFkappaB pathway PMID: 22166493
17. The regulatory function of Src and its modulation by PTP1B on oxidative phosphorylation in mitochondria. PMID: 21063895
18. the upregulation of PTP1B by platelet-derived growth factor or nitric oxide is both necessary and sufficient to induce the downregulation of protein kinase G via an effect on PKG mRNA levels. PMID: 21057040
19. results indicate that activation of PTP1B in the liver could induce hypertriglyceridaemia and that anchoring of PTP1B to the membrane is crucial for its action PMID: 19605464
20. results demonstrated that the increase in protein tyrosine phosphatase 1B expression and/or association with insulin receptor in monosodium glutamate animals may contribute to the impaired insulin signaling mainly in liver and muscle PMID: 12850498
21. PTP1B, best known as a negative regulator of the metabolic effects of insulin, is required for the effects of insulin on actin organization in immortalized fibroblasts PMID: 12902327
22. Protein-tyrosine phosphatase 1B is a new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression PMID: 12941932
23. Vascular injury induced by balloon catheter increases levels. These effects occur in PTP specific, as well as temporally and regionally specific, manner. PMID: 15271661
24. existence of an inhibitory feedback loop involving PDGF or FGF, and PTP1B in blood vessels PMID: 16373608
25. The catalytic domain of rat recombinant protein tyrosine phosphatase eta has been produced in Escherichia coli in soluble form, crystallized, and purified to homogeneity. PMID: 16946481
26. Diet-induced obesity increased expression and activity of the protein tyrosine phosphatase 1B and attenuated insulin signalling in gastrocnemius muscle of rats, which was reversed by single session of exercise. PMID: 17008371
27. increases in PTP1B contribute to hypothalamic leptin resistance as rats transition into middle age PMID: 17038557
28. PTP1B plays a role in the negative regulation of EGF-induced signaling and helps suppress cell cycle entry. PMID: 17563729
29. PTP1B overexpression in multiple tissues in obesity is regulated by inflammation PMID: 18281274
30. Chronic insulin treatment amplifies PDGF-BB induced motility in differentiated aortic smooth muscle cells by suppressing the expression and function of PTP1B. PMID: 18456732
31. Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2. PMID: 18566118
32. Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences.( PMID: 18583343

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KEGG: rno:24697

STRING: 10116.ENSRNOP00000014309

UniGene: Rn.11317