Recombinant Rat Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11)

1. the effect of SHP-2 on the proliferation, cell cycle and apoptosis of renal tubular epithelial cells was investigated. PMID: 29991025
2. Data demonstrate that the increased activation of MAPK signaling pathway by SHP2D61G could deregulate the surface expression of synaptic receptors during neuronal development. PMID: 28366775
3. findings demonstrate that IL-17 regulates SHP-2 expression and IL-17RA/STAT-3 dependent production of Cyr61, IL-23, GM-CSF and RANKL in AA-FLS and may reveal a new insight into the pathogenesis of RA. PMID: 28898718
4. Data suggest that phosphorylation of Shp2/Ptpn11 at Tyr542 and its translocation to postsynaptic compartment are integral processes in synaptic scaling/homeostasis; Shp2 phosphatase activity is critical to regulation of Ser(P)845 GluA1 and surface expression of GluA1 during synaptic scaling. (Shp2/Ptpn11 = protein tyrosine phosphatase non-receptor type 11; GluA1 = glutamate receptor ionotropic Ampa1 [alpha 1]) PMID: 28768764
5. results have revealed a regulatory mechanism of Shp2 underlying LTP and memory, broadening our understanding of Shp2 in cognitive function. PMID: 27417137
6. PKA phosphorylation of Shp2 protein inhibits its phosphatase activity and modulates ligand specificity PMID: 25802336
7. Data indicate that protein tyrosine phosphatases SHP-1, SHP-2 and PTP1B overexpressed during the development of cerulein -induced acute pancreatitis can be modulated by extracellular signal-regulated kinases (ERK1/2) and c-Jun NH2-terminal kinase (JNK). PMID: 24225419
8. our data show that in hemiparkinsonian rats developing dyskinesia, the aberrant phosphorylation of Shp-2 by D1R activation, represents an upstream molecular event leading to the persistent phosphorylation of Erk1/2 PMID: 23328768
9. key regulator of blood-testis barrier integrity and Sertoli cell support of spermatogenesis and fertility PMID: 23325809
10. Data indicate that the two LEOPARD syndrome mutations Q510E-Shp2 and Y279C-Shp2 both induce neonatal cardiomyocytes hypertrophy through similar mechanisms. PMID: 23673659
11. changes in mitochondria-localized signaling molecules Src and SHP2 constitute a potential signaling pathway to affect mitochondrial dysfunction in the heart during sepsis PMID: 22952679
12. These results indicate that SHP2 is recruited in focal adhesions of neural stem cells and regulates focal adhesion formation PMID: 22118986
13. The results have revealed that Shp2 functions as an intracellular inhibitor of apoptosis. These data provide insight into the pathogenesis of heart diseases. PMID: 22537548
14. the involvement of SHP2 activity in the regulation of the expression of the fatty acid-metabolizing enzyme ACSL4 PMID: 21903867
15. SHP-2 promotes oligodendrocytes maturation via Akt and ERK1/2 signaling in vitro. PMID: 21701583
16. SPRED1 is a likely substrate of SHP2, whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK pathway. PMID: 21531714
17. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin, beta-catenin, and p190RhoGAP and the activity of RhoA. PMID: 20023173
18. SHP-2 has a role as a positive regulator of cytokine receptor signaling by regulating ubiquitination/degradation pathways PMID: 14522994
19. Shp-1 and Shp-2 are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes PMID: 15115663
20. first tyrosine phosphatase shown to be present in mitochondria PMID: 15378208
21. These results demonstrate a unique role for SHP-2 in the regulation of the cellular architecture of vascular smooth muscle cells, suggesting the possibility that this phosphatase might be instrumental in vascular remodeling. PMID: 16021628
22. ROS-mediated oxidation of SHP-2 is essential for HB-EGF-mediated EGFR transactivation in ET-1 signaling pathway in NRK-52E cells. PMID: 16261333
23. studies demonstrate that SHP-1 & SHP-2 are expressed in myometrium & appear to be responsible for tyrosine phosphatase activity in this tissue, providing a molecular mechanism for modulation of phospholipase C-gamma1 phosphotyrosine levels in the uterus PMID: 16814162
24. Tyr-542 of SHP-2 modulates IL-1-induced Ca2+ signals and association of the ER with focal adhesions PMID: 16905534
25. Shp2 participates to the opposite effects induced in PC12 cells by EGF and NGF and that the interactions with the multidocking Gab2 protein mediate such effects. PMID: 17287109
26. Our results show that AP is associated with increases in the expression of SHP-1 and SHP-2 and changes in the dynamics of SHP-2 subcellular distribution in the early phase of Cer-induced AP. PMID: 18294464
27. Findings do not support an essential role of SHP2 in the pathogenesis of experimental pneumoniae meningitis, but it is possible that SHP2 protein expression may be used as a marker of disease activity. PMID: 18305318
28. SHP-2 dysregulation by increased Nox1-derived ROS in spontaneously hypertensive rats is associated with altered Ang II-AKT signaling. PMID: 18566342
29. Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences.( PMID: 18583343
30. Results indicate that a presynaptic signaling pathway through p120ctn, Fer, SHP-2, and beta-catenin promotes excitatory synapse development and function. PMID: 19047464
31. ROS-mediated oxidation of SHP-2 is essential for the hUII-induced mitogenic pathway in NRK-52E cells. PMID: 19326266
32. The SHP-2 is activated by ROS-mediated oxidative stress in astrocytes and functions as a component of the raft-mediated signaling pathway that acts through dephosphorylation and inactivation of other phosphotyrosine proteins, such as STAT-3. PMID: 19348936
33. Report role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis. PMID: 19359598
34. SHP-2 associated with Gab2 in rat basophilic leukemia cells; its association with Gab2 is enhanced following multimerization of FcERI and/or depolymerization of the filamentous actin. PMID: 15162432

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KEGG: rno:25622

STRING: 10116.ENSRNOP00000041842

UniGene: Rn.98209